Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer

• Published in: Oral oncology Vol. 45; no. 10; pp. e161 - e166
• Main Authors: Murugan, Avaniyapuram Kannan, Hong, Nguyen Thi, Cuc, Tran Thi Kim, Hung, Nguyen Chan, Munirajan, Arasambattu Kannan, Ikeda, Masa-Aki, Tsuchida, Nobuo
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2009
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - genetics; Codon; ERK2; Exons; Female; Genes, ras - genetics; H-RAS mutation; Hematology, Oncology and Palliative Medicine; Humans; Male; Middle Aged; Mitogen-Activated Protein Kinase 1 - genetics; Mouth Neoplasms - genetics; Mutation - genetics; Mutation, Missense - genetics; Oncogene; Oral carcinoma; OSCC; Otolaryngology; Polymorphism, Single Nucleotide; Risk Factors; Vietnam; Vietnam; Oral carcinoma; OSCC; Vietnam; ERK2; H-RAS mutation; Oncogene

Summary Oral squamous cell carcinoma is the sixth most common cancer in the world and the seventh most common cancer in Vietnam. The RAS and PI3K-AKT signaling pathways play an important role in oral carcinogenesis. Our previous study on PI3K signaling pathway showed the absence of PIK3CA and PTEN g...