In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials - Church, Rachel J; Watkins, Paul B (Experimental biology and medicine (Maywood, N.J.), 2018)
Keywords: Alanine Transaminase - blood; Alkaline Phosphatase - blood; Apoptosis - drug effects; Aspartate Aminotransferases - blood; Bilirubin - blood; Biomarkers - blood; Chemical and Drug Induced Liver Injury - blood; Chemical and Drug Induced Liver Injury - diagnosis; Computer Simulation; Humans; Liver - pathology; Liver Function Tests; Minireview; Necrosis - blood; Necrosis - chemically induced; Necrosis - diagnosis; Neuregulin-1 - adverse effects; Peptides - adverse effects; drug-induced liver injury; Biomarkers; hepatoxicity; Hy’s Law; DILIsym; evaluation of drug-induced severe hepatoxicity