Challenges in delivering therapeutic peptides and proteins: A silk-based solution

• Published in: Journal of controlled release Vol. 345; pp. 176 - 189
• Main Authors: Wu, Junqi, Sahoo, Jugal Kishore, Li, Yamin, Xu, Qiaobing, Kaplan, David L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2022
• Subjects: Biomaterials; denaturation; Drug delivery; Drug Delivery Systems; Drug release; drugs; Hydrogels; Peptide/protein drugs; Peptides; Polymers; Silk; therapeutics; Drug release; Silk; Drug delivery; Peptide/protein drugs; Biomaterials

Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders, oncology, and many other clinical needs. Yet, protecting peptide- and protein-based drugs from degradation and denaturation during processin...