Challenges in delivering therapeutic peptides and proteins: A silk-based solution

Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders, oncology, and many other clinical needs. Yet, protecting peptide- and protein-based drugs from degradation and denaturation during processin...

Full description

Saved in:
Bibliographic Details
Published inJournal of controlled release Vol. 345; pp. 176 - 189
Main Authors Wu, Junqi, Sahoo, Jugal Kishore, Li, Yamin, Xu, Qiaobing, Kaplan, David L.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.05.2022
Subjects
Biomaterials
denaturation
Drug delivery
Drug Delivery Systems
Drug release
drugs
Hydrogels
Peptide/protein drugs
Peptides
Polymers
Silk
therapeutics
Drug release
Silk
Drug delivery
Peptide/protein drugs
Biomaterials
Online AccessGet full text

Cover

Abstract Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders, oncology, and many other clinical needs. Yet, protecting peptide- and protein-based drugs from degradation and denaturation during processing, storage and delivery remain significant challenges. In this review, we introduce the properties of peptide- and protein-based drugs and the challenges associated with their stability and delivery. Then, we discuss delivery strategies using synthetic polymers and their advantages and limitations. This is followed by a focus on silk protein-based materials for peptide/protein drug processing, storage, and delivery, as a path to overcome stability and delivery challenges with current systems. [Display omitted] •The challenges of delivering peptide and protein-based drugs are discussed•The advantages and limitations of synthetic polymer delivery system is introduced for protein and peptide-based drugs•Silk based delivery system is highlighted for deliverying and stabilizing protein and peptide-based drugs
AbstractList Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders, oncology, and many other clinical needs. Yet, protecting peptide- and protein-based drugs from degradation and denaturation during processing, storage and delivery remain significant challenges. In this review, we introduce the properties of peptide- and protein-based drugs and the challenges associated with their stability and delivery. Then, we discuss delivery strategies using synthetic polymers and their advantages and limitations. This is followed by a focus on silk protein-based materials for peptide/protein drug processing, storage, and delivery, as a path to overcome stability and delivery challenges with current systems. [Display omitted] •The challenges of delivering peptide and protein-based drugs are discussed•The advantages and limitations of synthetic polymer delivery system is introduced for protein and peptide-based drugs•Silk based delivery system is highlighted for deliverying and stabilizing protein and peptide-based drugs
Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders, oncology, and many other clinical needs. Yet, protecting peptide- and protein-based drugs from degradation and denaturation during processing, storage and delivery remain significant challenges. In this review, we introduce the properties of peptide- and protein-based drugs and the challenges associated with their stability and delivery. Then, we discuss delivery strategies using synthetic polymers and their advantages and limitations. This is followed by a focus on silk protein-based materials for peptide/protein drug processing, storage, and delivery, as a path to overcome stability and delivery challenges with current systems.Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders, oncology, and many other clinical needs. Yet, protecting peptide- and protein-based drugs from degradation and denaturation during processing, storage and delivery remain significant challenges. In this review, we introduce the properties of peptide- and protein-based drugs and the challenges associated with their stability and delivery. Then, we discuss delivery strategies using synthetic polymers and their advantages and limitations. This is followed by a focus on silk protein-based materials for peptide/protein drug processing, storage, and delivery, as a path to overcome stability and delivery challenges with current systems.
Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders, oncology, and many other clinical needs. Yet, protecting peptide- and protein-based drugs from degradation and denaturation during processing, storage and delivery remain significant challenges. In this review, we introduce the properties of peptide- and protein-based drugs and the challenges associated with their stability and delivery. Then, we discuss delivery strategies using synthetic polymers and their advantages and limitations. This is followed by a focus on silk protein-based materials for peptide/protein drug processing, storage, and delivery, as a path to overcome stability and delivery challenges with current systems.
Author Wu, Junqi
Sahoo, Jugal Kishore
Li, Yamin
Kaplan, David L.
Xu, Qiaobing
Author_xml – sequence: 1
  givenname: Junqi
  surname: Wu
  fullname: Wu, Junqi
– sequence: 2
  givenname: Jugal Kishore
  surname: Sahoo
  fullname: Sahoo, Jugal Kishore
– sequence: 3
  givenname: Yamin
  surname: Li
  fullname: Li, Yamin
– sequence: 4
  givenname: Qiaobing
  surname: Xu
  fullname: Xu, Qiaobing
  email: qiaobing.xu@tufts.edu
– sequence: 5
  givenname: David L.
  surname: Kaplan
  fullname: Kaplan, David L.
  email: David.kaplan@tufts.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35157939$$D View this record in MEDLINE/PubMed
BookMark eNqNkV9rFDEUxYNU7Lb1Iyjz6Mus-TOZJAqWsqgVCiLY55BN7uxmzSZjMrvgtzfLrkX7UuFCHu7vHE7uuUBnMUVA6BXBc4JJ_3Yz39gUM4Q5xZTOcR1CnqEZkYK1nVL8DM0qJ1vWc3WOLkrZYIw568QLdM444UIxNUPfFmsTAsQVlMbHxkHwe8g-rpppDdmMsJu8bUYYJ-8qYqJrxpwm8LG8a26a4sOPdmkKuKakUNkUr9DzwYQCL0_vJbr_9PH74ra9-_r5y-LmrrUc46kVQuF-aTtJBKVcEkOsGTpplLHc1s3gzOAoFhSDdcJ0TBHCeU8NW1puesou0Yej77hbbsFZiFM2QY_Zb03-pZPx-t9N9Gu9SnutCGNY9tXgzckgp587KJPe-mIhBBMh7YqmfSdlh6Xq_gOlCnMh5CHW679jPeT5c_IK8CNgcyolw_CAEKwP1eqNPlWrD9VqXIeQqnv_SGf9ZA4Xr7_z4Un19VENtZK9h6yL9RAtOJ_BTtol_4TDbws5w_o
CitedBy_id crossref_primary_10_1021_acsanm_3c03451
crossref_primary_10_1016_j_jddst_2025_106652
crossref_primary_10_1016_j_actbio_2023_09_018
crossref_primary_10_1021_acsbiomaterials_3c01758
crossref_primary_10_1016_j_ijbiomac_2024_131514
crossref_primary_10_1021_acsami_4c07290
crossref_primary_10_1016_j_ejpb_2024_114528
crossref_primary_10_1021_acs_biomac_2c01349
crossref_primary_10_1021_acs_molpharmaceut_4c01144
crossref_primary_10_1002_SMMD_20220011
crossref_primary_10_1016_j_addr_2022_114622
crossref_primary_10_1080_20415990_2024_2433938
crossref_primary_10_1016_j_cej_2024_153977
crossref_primary_10_1186_s40580_024_00421_w
crossref_primary_10_1016_j_nanoen_2024_110345
crossref_primary_10_1021_acs_molpharmaceut_2c00512
crossref_primary_10_1007_s00210_023_02683_3
crossref_primary_10_1016_j_ejps_2024_106963
crossref_primary_10_3390_mi15040533
crossref_primary_10_1016_j_cclet_2023_109169
crossref_primary_10_1002_adma_202208556
crossref_primary_10_1007_s13346_023_01372_1
crossref_primary_10_1021_acsami_2c18452
crossref_primary_10_1016_j_carbpol_2023_120838
crossref_primary_10_1016_j_carbpol_2023_121408
crossref_primary_10_1038_s41570_023_00486_x
crossref_primary_10_3390_pharmaceutics15020355
crossref_primary_10_3390_applnano5030011
crossref_primary_10_1002_mabi_202300190
crossref_primary_10_1016_j_ijbiomac_2025_140291
crossref_primary_10_1039_D3RA06476J
crossref_primary_10_2147_IJN_S448578
crossref_primary_10_1021_acsami_4c16424
crossref_primary_10_1021_polymscitech_4c00026
crossref_primary_10_1093_rb_rbac099
crossref_primary_10_1016_j_bioadv_2024_213925
crossref_primary_10_1016_j_biomaterials_2024_123038
crossref_primary_10_3390_pharmaceutics15112641
crossref_primary_10_1039_D3TB02387G
crossref_primary_10_1039_D4NR03638G
crossref_primary_10_3390_ma16216960
crossref_primary_10_1007_s10495_024_02026_4
crossref_primary_10_1248_bpb_b24_00722
crossref_primary_10_1016_j_ijbiomac_2024_132254
crossref_primary_10_1021_acsabm_2c00836
crossref_primary_10_1016_j_biopha_2024_116910
crossref_primary_10_1002_adfm_202303033
crossref_primary_10_1007_s00011_024_01893_6
crossref_primary_10_1007_s12088_024_01274_x
crossref_primary_10_1021_acsnano_4c02344
crossref_primary_10_1007_s13770_024_00698_2
crossref_primary_10_1080_17425247_2022_2110582
crossref_primary_10_1124_jpet_123_001689
crossref_primary_10_1186_s12951_024_02758_0
Cites_doi 10.1038/nprot.2011.379
10.1089/jam.2006.19.473
10.1016/S1773-2247(13)50020-7
10.1016/S0169-409X(03)00040-1
10.1080/21688370.2016.1156805
10.4103/0250-474X.58165
10.1016/S0939-6411(03)00104-8
10.1211/146080800128736169
10.1099/jmm.0.011122-0
10.1016/j.ejpb.2007.12.014
10.1002/adfm.201102012
10.1002/jps.21183
10.1208/s12248-015-9719-7
10.1016/j.jmbbm.2011.11.007
10.1016/j.addr.2010.03.009
10.1111/cbdd.12055
10.1016/j.msec.2019.05.004
10.1016/j.ijpharm.2009.12.052
10.1111/j.1540-8159.1983.tb04406.x
10.1016/j.jsps.2014.06.004
10.3390/colloids3020043
10.1016/j.jconrel.2015.09.037
10.1039/C6TB00308G
10.1016/j.biomaterials.2013.06.039
10.1021/bm401381s
10.1002/adhm.201300139
10.1038/natrevmats.2016.71
10.4155/tde.13.104
10.4103/0970-2113.92361
10.1016/j.biomaterials.2019.119720
10.1073/pnas.1902179116
10.1016/j.addr.2012.01.016
10.1007/s11051-008-9549-y
10.1016/j.addr.2016.03.012
10.1016/S0142-9612(96)00076-2
10.1016/j.ejpb.2015.01.018
10.1016/j.addr.2012.04.005
10.1039/C8TB00607E
10.1002/adfm.201400526
10.1016/j.bpj.2009.07.028
10.1517/17425247.5.8.889
10.1093/asj/sjy094
10.1021/acsbiomaterials.9b00229
10.1016/0142-9612(95)91130-Q
10.1016/j.biomaterials.2009.11.002
10.1016/0141-0229(81)90068-5
10.3390/pharmaceutics10020055
10.1016/j.progpolymsci.2015.02.001
10.1186/s12951-016-0238-1
10.1002/adfm.201201512
10.1021/acs.biomac.0c00090
10.1021/acs.biomac.9b00159
10.1021/bm800874q
10.12688/f1000research.9970.1
10.1016/j.jsb.2009.12.012
10.1007/s40005-019-00439-x
10.1016/j.biomaterials.2004.02.047
10.1002/adhm.201900644
10.1007/978-1-61779-921-1_1
10.1016/j.ejpb.2018.05.017
10.1615/CritRevTherDrugCarrierSyst.2013006475
10.1016/j.bmc.2017.06.052
10.3390/s150716265
10.3390/ijms10094033
10.1016/j.colsurfb.2015.06.049
10.1021/bm800956n
10.1016/j.biomaterials.2015.08.039
10.2174/0929866521666140807114240
10.1016/j.dental.2006.02.011
10.3390/pharmaceutics7040438
10.1016/j.polymer.2008.01.027
10.1039/D0BM00512F
10.1002/jbm.1261
10.1021/bm101421r
10.1002/term.2226
10.1016/j.jconrel.2014.05.059
10.1016/j.biomaterials.2004.09.020
10.1002/ijch.201300083
10.1002/adfm.201300435
10.1016/j.freeradbiomed.2005.09.012
10.1016/S0142-9612(00)00129-0
10.1002/mabi.201500013
10.1101/cshperspect.a028241
10.4103/0250-474X.42967
10.1016/0142-9612(96)85754-1
10.1016/j.biomaterials.2005.12.015
10.1016/j.addr.2016.05.020
10.1016/S0168-3659(98)00082-0
10.1039/C7RA12394A
10.1016/j.csbj.2019.09.004
10.1016/j.jconrel.2006.11.021
10.4155/tde.14.5
10.1615/CritRevTherDrugCarrierSyst.v19.i1.20
10.1186/scrt396
10.1080/17425247.2019.1651716
10.1038/s41573-020-00135-8
10.1002/adtp.201900140
10.1039/C4TB01555J
10.1021/bm901209u
10.1021/bm200062a
10.1016/j.biomaterials.2007.11.003
10.1002/adma.200902643
10.1016/j.biomaterials.2012.08.070
10.1111/bcpt.12342
10.2217/imt.14.37
10.1080/1061186X.2019.1669043
10.1016/S0939-6411(00)00090-4
10.5999/aps.2015.42.2.186
10.1038/s41563-019-0560-8
10.1038/nbt.1504
10.1002/mabi.200700022
10.1186/s40824-020-00190-7
10.3390/ijms10041514
10.1002/adhm.201800465
10.1038/ncomms15902
10.1016/j.ejpb.2014.04.011
10.4155/tde.10.16
10.1016/j.smim.2007.11.005
10.1089/ten.2006.12.301
10.4155/tde-2017-0037
10.1016/S0141-0229(01)00340-4
10.1021/acs.chemrev.5b00346
10.1016/j.progpolymsci.2007.05.013
10.1517/17425241003602259
10.1016/j.biomaterials.2010.02.024
10.1016/j.addr.2020.10.008
10.3109/02652049309015322
10.1146/annurev-chembioeng-073009-100847
10.1021/am504159j
10.1016/0168-3659(85)90042-2
10.2165/00003088-198409010-00001
10.1016/j.ijpharm.2008.02.010
10.1517/17425247.2011.568936
10.3390/ma11081280
10.1016/j.ejpb.2014.12.029
10.1021/acsabm.0c00671
ContentType Journal Article
Copyright 2022 Elsevier B.V.
Copyright © 2022 Elsevier B.V. All rights reserved.
Copyright_xml – notice: 2022 Elsevier B.V.
– notice: Copyright © 2022 Elsevier B.V. All rights reserved.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
5PM
DOI 10.1016/j.jconrel.2022.02.011
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList
MEDLINE - Academic
AGRICOLA
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1873-4995
EndPage 189
ExternalDocumentID PMC9133086
35157939
10_1016_j_jconrel_2022_02_011
S0168365922000852
Genre Journal Article
Review
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIBIB NIH HHS
  grantid: R01 EB027170
GroupedDBID ---
--K
--M
.GJ
.~1
0R~
1B1
1RT
1~.
1~5
29K
3O-
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
AABNK
AABXZ
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AATCM
AAXUO
AAYOK
ABFNM
ABFRF
ABJNI
ABMAC
ABOCM
ABXDB
ABYKQ
ABZDS
ACDAQ
ACGFO
ACGFS
ACIUM
ACNNM
ACRLP
ADBBV
ADEZE
ADMUD
AEBSH
AEFWE
AEKER
AENEX
AEZYN
AFKWA
AFRZQ
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
C45
CS3
D-I
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HMT
HVGLF
HZ~
IHE
J1W
KOM
M34
M41
MO0
N9A
O-L
O9-
OAUVE
OGGZJ
OVD
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
RNS
ROL
RPZ
SCC
SDF
SDG
SDP
SES
SEW
SPC
SPCBC
SPT
SSM
SSP
SSZ
T5K
TEORI
WUQ
~G-
AAHBH
AATTM
AAXKI
AAYWO
AAYXX
ABWVN
ACRPL
ACVFH
ADCNI
ADNMO
AEIPS
AEUPX
AFJKZ
AFPUW
AGCQF
AGQPQ
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
BNPGV
CITATION
SSH
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
5PM
EFKBS
ID FETCH-LOGICAL-c500t-77906bc481722581a1caf48a9ac5c06bfdafd20720ecd7a439115562a3bc5a623
IEDL.DBID .~1
ISSN 0168-3659
1873-4995
IngestDate Thu Aug 21 18:36:56 EDT 2025
Thu Jul 10 18:40:47 EDT 2025
Fri Jul 11 05:24:08 EDT 2025
Thu Apr 03 07:01:05 EDT 2025
Tue Jul 01 04:10:06 EDT 2025
Thu Apr 24 23:03:48 EDT 2025
Fri Feb 23 02:40:08 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Drug release
Silk
Drug delivery
Peptide/protein drugs
Biomaterials
Language English
License Copyright © 2022 Elsevier B.V. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c500t-77906bc481722581a1caf48a9ac5c06bfdafd20720ecd7a439115562a3bc5a623
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/9133086
PMID 35157939
PQID 2629057782
PQPubID 23479
PageCount 14
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_9133086
proquest_miscellaneous_2648840894
proquest_miscellaneous_2629057782
pubmed_primary_35157939
crossref_primary_10_1016_j_jconrel_2022_02_011
crossref_citationtrail_10_1016_j_jconrel_2022_02_011
elsevier_sciencedirect_doi_10_1016_j_jconrel_2022_02_011
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-05-01
PublicationDateYYYYMMDD 2022-05-01
PublicationDate_xml – month: 05
  year: 2022
  text: 2022-05-01
  day: 01
PublicationDecade 2020
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Journal of controlled release
PublicationTitleAlternate J Control Release
PublicationYear 2022
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Pappalardo, Mathisen, Finne-Wistrand (bb0460) 2019; 20
Wongpinyochit, Johnston, Seib (bb0650) 2016; 116
Gokhale, Satyanarayanajois (bb0005) 2014; 6
Guo, Li, Kaplan (bb0595) 2020; 21
Li, Kluge, Guziewicz, Omenetto, Kaplan (bb0935) 2015; 219
Hopkins, De Laporte, Tortelli, Spedden, Staii, Atherton, Hubbell, Kaplan (bb0890) 2013; 23
Navone, Pascucci, Dossena, Ferri, Invernici, Acerbi, Cristini, Bedini, Tosetti, Ceserani, Bonomi, Pessina, Freddi, Alessandrino, Ceccarelli, Campanella, Marfia, Alessandri, Parati (bb0695) 2014; 5
Hasturk, Jordan, Choi, Kaplan (bb0855) 2020; 232
Kim, Park, Prausnitz (bb0375) 2012; 64
Diab, Pritchard, Uhrig, Boerckel, Kaplan, Guldberg (bb0885) 2012; 11
Muheem, Shakeel, Jahangir, Anwar, Mallick, Jain, Warsi, Ahmad (bb0055) 2016; 24
Baran, Erbil (bb0325) 2019; 3
Dong, Dong, Huang, Mei, Xia, Wang, Pan, Li, Wu (bb0725) 2015; 91
Choi, McGill, Raia, Hasturk, Kaplan (bb0865) 2019; 8
Guo, Li, Vu, Hanna, Lechtig, Qiu, Mu, Ling, Nazarian, Lin, Kaplan (bb0670) 2020; 19
Singh, Singh, Lillard (bb0080) 2008; 97
DeMuth, Min, Irvine, Hammond (bb0930) 2014; 3
Nguyen, Bozorg, Kim, Wieber, Birk, Lubda, Banga (bb0385) 2018; 129
Thurber, Omenetto, Kaplan (bb0495) 2015; 71
Lovett, Wang, Yucel, York, Keirstead, Haggerty, Kaplan (bb0880) 2015; 95
Li, Zhu, Chen, Jia, Ma (bb0810) 2017; 7
Jones (bb0490) 2008; 20
Wang, Yucel, Lu, Hu, Kaplan (bb0785) 2010; 31
Meinel, Hofmann, Karageorgiou, Kirker-Head, McCool, Gronowicz, Zichner, Langer, Vunjak-Novakovic, Kaplan (bb0690) 2005; 26
Oyston, Fox, Richards, Clark (bb0010) 2009; 58
Shi, Abbah, Saran, Zhang, Li, Wong, Goh (bb0830) 2013; 14
Wang, Zhu, Zhao, Kuang, Kundu, Lu (bb0920) 2019; 5
Barui (bb0335) 2018
Zhu, Yang, He, Tian, Tang, Chen (bb0715) 2015; 135
Thurber, Omenetto, Kaplan (bb0685) 2015; 71
Fu, Kao (bb0565) 2010; 7
Taluja, Bae (bb0580) 2008; 358
Shaji, Patole (bb0060) 2008; 70
Kim, Kim, Kim, Chung (bb0905) 2015; 15
Vepari, Kaplan (bb0600) 2007; 32
Qu, Wang, Niu, Lin, Huang, Jiang, Li (bb0795) 2018; 11
Lammel, Hu, Park, Kaplan, Scheibel (bb0805) 2010; 31
Hoare, Kohane (bb0370) 2008; 49
Rosales, Uribe-Querol (bb0760) 2017
Yan, Zhang, Ma, Zhou (bb0815) 2008; 11
Li, Kluge, Guziewicz, Omenetto, Kaplan (bb0655) 2015; 219
HAD, Alexaki, Simhadri, Katagiri, Jankowski, Sauna, Kimchi-Sarfaty (bb0025) 2017; 6
Charm, Wong (bb0350) 1981; 3
Horan, Antle, Collette, Wang, Huang, Moreau, Volloch, Kaplan, Altman (bb0740) 2005; 26
Seib, Kaplan (bb0640) 2013; 53
Yucel, Lovett, Kaplan (bb0755) 2014; 190
Sung, Kim (bb0270) 2020; 24
Faisant, Siepmann, Richard, Benoit (bb0425) 2003; 56
Alkilani, McCrudden, Donnelly (bb0150) 2015; 7
Choi, Hasturk, Mu, Sahoo, Kaplan (bb0870) 2021
Jain, Chitkara, Kumar (bb0260) 2008; 5
Ceonzo, Gaynor, Shaffer, Kojima, Vacanti, Stahl (bb0530) 2006; 12
Paudel, Milewski, Swadley, Brogden, Ghosh, Stinchcomb (bb0155) 2010; 1
Pande (bb0555) 1983; 6
Li, Mooney (bb0365) 2016; 1
Spring (bb0560) 2018; 38
L-T, Singh (bb0515) 1989
Patel, Patel, Yang, Mitra (bb0240) 2014; 21
Yucel, Lovett, Kaplan (bb0400) 2014; 190
Vo, Kasper, Mikos (bb0800) 2012; 64
Pond, Tozer (bb0105) 1984; 9
Lee, Yun, Park (bb0280) 2016; 107
Yucel, Lovett, Kaplan (bb0630) 2014; 190
Huang, Wang, Dong, Pan, Li, Wu (bb0825) 2014; 88
Montanari, Costantini, Signoretti, Valvo, Santucci, Bartolomei, Fattibene, Onori, Faucitano, Conti, Genta (bb0420) 1998; 56
Bialik, Kuras, Sobczak, Oledzka (bb0245) 2019; 16
Biddlecombe, Craig, Zhang, Uddin, Mulot, Fish, Bracewell (bb0355) 2007; 23
Kamaly, Yameen, Wu, Farokhzad (bb0445) 2016; 116
Athanasiou, Niederauer, Agrawal (bb0535) 1996; 17
Colombié, Gaunand, Lindet (bb0360) 2001; 28
DeMuth, Garcia-Beltran, Ai-Ling, Hammond, Irvine (bb0380) 2013; 23
Zbikowska, Nowak, Wachowicz (bb0435) 2006; 40
Burczak, Gamian, Kochman (bb0500) 1996; 17
Koh, Cheng, Teng, Khin, Loh, Tee, Low, Ye, Yu, Zhang, Han (bb0610) 2015; 46
Pritchard, Kaplan (bb0735) 2011; 8
Yan, Oliveira, Oliveira, Reis (bb0895) 2017; 11
Bruno, Miller, Lim (bb0045) 2013; 4
Wang, Wenk, Matsumoto, Meinel, Li, Kaplan (bb0780) 2007; 117
Lalla, Sapna (bb0430) 1993; 10
Borgström, Olsson, Thorsson (bb0115) 2006; 19
Lowinger, Barrett, Zhang, Williams (bb0545) 2018; 10
Newman (bb0110) 2017; 8
Schwendeman (bb0575) 2002; 19
Böstman, Pihlajamäki (bb0540) 2000; 21
Breslauer, Muller, Lee (bb0765) 2010; 11
Muttenthaler, King, Adams, Alewood (bb0040) 2021; 20
West (bb0125) 2003; 285
Cao, Wang (bb0605) 2009; 10
Cao, Mitchell, Messina, Price, Thompson, Penington, Morrison, O'Connor, Stevens, Cooper-White (bb0485) 2006; 27
Bajracharya, Song, Back, Han (bb0090) 2019; 17
Athanasiou, Niederauer, Agrawal (bb0415) 1996; 17
Lau, Dunn (bb0015) 2018; 26
Dombu, Betbeder (bb0145) 2013; 34
Geraldes, Beraldo-de-Araújo, Pardo, Pessoa Junior, Stephano, de Oliveira-Nascimento (bb0030) 2020; 28
Meredith, Salameh, Banks (bb0135) 2015; 17
Giteau, Venier-Julienne, Aubert-Pouëssel, Benoit (bb0585) 2008
Tsioris, Raja, Pritchard, Panilaitis, Kaplan, Omenetto (bb0910) 2012; 22
Hino, Shimabayashi, Nakai (bb0775) 2000; 6
Gajra, Pandya, Vidyasagar, Rabari, Dedania, Rao (bb0275) 2011; 4
Heller (bb0250) 1985; 2
Rockwood, Preda, Yücel, Wang, Lovett, Kaplan (bb0645) 2011; 6
Dinis, Elia, Vidal, Auffret, Kaplan, Egles (bb0835) 2014; 6
Partlow, Hanna, Rnjak-Kovacina, Moreau, Applegate, Burke, Marelli, Mitropoulos, Omenetto, Kaplan (bb0860) 2014; 24
Boegh, Nielsen (bb0190) 2015; 116
Hines, Kaplan (bb0750) 2011; 12
Wang, Kluge, Leisk, Kaplan (bb0845) 2008; 29
Craik, Fairlie, Liras, Price (bb0050) 2013; 81
Liechty, Kryscio, Slaughter, Peppas (bb0065) 2010; 1
Yamamoto, Kaneo, Maitani (bb0340) 2013; 23
Shimanovich, Ruggeri, De Genst, Adamcik, Barros, Porter, Müller, Mezzenga, Dobson, Vollrath, Holland, Knowles (bb0770) 2017; 8
Tallury, Alimohammadi, Kalachandra (bb0570) 2007; 23
Gong, Wang, Zhang, Wu, Zheng, Xie, Kaplan, Li, Wang (bb0790) 2019; 102
Boopathy, Mandal, Kulp, Menis, Bennett, Watkins, Wang, Martin, Thai, He, Schief, Hammond, Irvine (bb0925) 2019; 116
Dimitrov (bb0075) 2012; 899
Castel, Soon-Sutton, Deptula, Flaherty, Parsa (bb0550) 2015; 42
Sahoo, Choi, Hasturk, Laubach, Descoteaux, Mosurkal, Wang, Zhang, Kaplan (bb0730) 2020; 8
Wang, Ding, Wang, Chen, Xu, Lu, Kaplan (bb0710) 2018; 6
Zhao, Wang, Mao, Leong (bb0255) 2003; 55
Zhao, Lin, Yildirimer, Dhinakar, Zhao, Wu (bb0070) 2016; 4
Buckley, Hubálek, Rahbek (bb0590) 2016; 4
Leisk, Lo, Yucel, Lu, Kaplan (bb0850) 2010; 22
Silva, Motta, Rodrigues, Pinheiro, Gomes, Mano, Reis, Migliaresi (bb0705) 2008; 9
Fisher, Pavlenko, Vlasov, Ramenskaya (bb0020) 2019; 33
Ramot, Haim-Zada, Domb, Nyska (bb0450) 2016; 107
Yucel, Kojic, Leisk, Lo, Kaplan (bb0875) 2010; 170
Muheem, Shakeel, Jahangir, Anwar, Mallick, Jain, Warsi, Ahmad (bb0095) 2016; 24
Ali (bb0100) 2010
Bustamante-Marin, Ostrowski (bb0120) 2017; 9
Hines, Kaplan (bb0520) 2013; 30
Guziewicz, Massetti, Perez-Ramirez, Kaplan (bb0900) 2013; 34
Numata, Kaplan (bb0635) 2010; 62
Patil, Sarasija (bb0130) 2012; 29
Kundu, Chung, Kim, Tae, Kundu (bb0820) 2010; 388
Patel, Cholkar, Mitra (bb0085) 2014; 5
Research AM (bb0035) 2017
Khare, Peppas (bb0505) 1995; 16
Holland, Numata, Rnjak-Kovacina, Seib (bb0700) 2019; 8
Lu, Wang, Lu, Hu, Uppal, Omenetto, Kaplan (bb0675) 2009; 10
Lyu, Untereker (bb0465) 2009; 10
Rnjak-Kovacina, DesRochers, Burke, Kaplan (bb0680) 2015; 15
Brooks (bb0720) 2015; 3
Igartua, Hernández, Rosas, Patarroyo, Pedraz (bb0405) 2008; 69
Lee, He, Tsai, Lin (bb0390) 2015; 3
Prausnitz, Langer (bb0160) 2008; 26
Liu, Luo, Xing (bb0395) 2020; 3
Yavuz, Chambre, Harrington, Kluge, Valenti, Kaplan (bb0915) 2020; 3
Lankalapalli, Kolapalli (bb0265) 2009; 71
Elmowafy, Tiboni, Soliman (bb0470) 2019; 49
Numata, Kaplan (bb0615) 2010; 62
Carbinatto, de Castro, Evangelista, Cury (bb0510) 2014; 9
Abuhanoğlu, Ozer (bb0410) 2014; 6
Chambre, Martín-Moldes, Parker, Kaplan (bb0625) 2020; 160
Lassalle, Ferreira (bb0345) 2007; 7
(bb0665) 1991
Peppas, Bures, Leobandung, Ichikawa (bb0745) 2000; 50
Hu, Shmelev, Sun, Gil, Park, Cebe, Kaplan (bb0660) 2011; 12
Meredith, Salameh, Banks (bb0140) 2015; 17
Li, Wu, Shi, Xia, Sahoo, Yeo, Kaplan (bb0620) 2021
da Luz, Boyles, Falagan-Lotsch, Pereira, Tutumi, de Oliveira, Martins, Himly, Sommer, Foissner, Duschl, Granjeiro, Leite (bb0475) 2017; 15
Kohane, Langer, Kinney, Lipp, Anthony, Louis (bb0455) 2002; 59
Yucel, Cebe, Kaplan (bb0840) 2009; 97
Ramot, Haim-Zada, Domb, Nyska (bb0480) 2016; 107
Athanasiou (10.1016/j.jconrel.2022.02.011_bb0535) 1996; 17
Silva (10.1016/j.jconrel.2022.02.011_bb0705) 2008; 9
Shaji (10.1016/j.jconrel.2022.02.011_bb0060) 2008; 70
Peppas (10.1016/j.jconrel.2022.02.011_bb0745) 2000; 50
Research AM (10.1016/j.jconrel.2022.02.011_bb0035) 2017
Li (10.1016/j.jconrel.2022.02.011_bb0365) 2016; 1
Bajracharya (10.1016/j.jconrel.2022.02.011_bb0090) 2019; 17
Numata (10.1016/j.jconrel.2022.02.011_bb0615) 2010; 62
Horan (10.1016/j.jconrel.2022.02.011_bb0740) 2005; 26
Singh (10.1016/j.jconrel.2022.02.011_bb0080) 2008; 97
Hines (10.1016/j.jconrel.2022.02.011_bb0520) 2013; 30
Meinel (10.1016/j.jconrel.2022.02.011_bb0690) 2005; 26
Kohane (10.1016/j.jconrel.2022.02.011_bb0455) 2002; 59
Yucel (10.1016/j.jconrel.2022.02.011_bb0755) 2014; 190
Liu (10.1016/j.jconrel.2022.02.011_bb0395) 2020; 3
Ramot (10.1016/j.jconrel.2022.02.011_bb0480) 2016; 107
Spring (10.1016/j.jconrel.2022.02.011_bb0560) 2018; 38
Guo (10.1016/j.jconrel.2022.02.011_bb0595) 2020; 21
Biddlecombe (10.1016/j.jconrel.2022.02.011_bb0355) 2007; 23
Igartua (10.1016/j.jconrel.2022.02.011_bb0405) 2008; 69
Gokhale (10.1016/j.jconrel.2022.02.011_bb0005) 2014; 6
Shimanovich (10.1016/j.jconrel.2022.02.011_bb0770) 2017; 8
Meredith (10.1016/j.jconrel.2022.02.011_bb0140) 2015; 17
Burczak (10.1016/j.jconrel.2022.02.011_bb0500) 1996; 17
Hines (10.1016/j.jconrel.2022.02.011_bb0750) 2011; 12
Boegh (10.1016/j.jconrel.2022.02.011_bb0190) 2015; 116
Qu (10.1016/j.jconrel.2022.02.011_bb0795) 2018; 11
Liechty (10.1016/j.jconrel.2022.02.011_bb0065) 2010; 1
HAD (10.1016/j.jconrel.2022.02.011_bb0025) 2017; 6
Newman (10.1016/j.jconrel.2022.02.011_bb0110) 2017; 8
Ceonzo (10.1016/j.jconrel.2022.02.011_bb0530) 2006; 12
Taluja (10.1016/j.jconrel.2022.02.011_bb0580) 2008; 358
Thurber (10.1016/j.jconrel.2022.02.011_bb0685) 2015; 71
Ramot (10.1016/j.jconrel.2022.02.011_bb0450) 2016; 107
Patel (10.1016/j.jconrel.2022.02.011_bb0240) 2014; 21
Lovett (10.1016/j.jconrel.2022.02.011_bb0880) 2015; 95
Buckley (10.1016/j.jconrel.2022.02.011_bb0590) 2016; 4
Yucel (10.1016/j.jconrel.2022.02.011_bb0630) 2014; 190
Oyston (10.1016/j.jconrel.2022.02.011_bb0010) 2009; 58
Yan (10.1016/j.jconrel.2022.02.011_bb0815) 2008; 11
Geraldes (10.1016/j.jconrel.2022.02.011_bb0030) 2020; 28
Charm (10.1016/j.jconrel.2022.02.011_bb0350) 1981; 3
Yucel (10.1016/j.jconrel.2022.02.011_bb0400) 2014; 190
Jones (10.1016/j.jconrel.2022.02.011_bb0490) 2008; 20
Hasturk (10.1016/j.jconrel.2022.02.011_bb0855) 2020; 232
Breslauer (10.1016/j.jconrel.2022.02.011_bb0765) 2010; 11
Leisk (10.1016/j.jconrel.2022.02.011_bb0850) 2010; 22
Baran (10.1016/j.jconrel.2022.02.011_bb0325) 2019; 3
Chambre (10.1016/j.jconrel.2022.02.011_bb0625) 2020; 160
Guziewicz (10.1016/j.jconrel.2022.02.011_bb0900) 2013; 34
Partlow (10.1016/j.jconrel.2022.02.011_bb0860) 2014; 24
Lassalle (10.1016/j.jconrel.2022.02.011_bb0345) 2007; 7
Elmowafy (10.1016/j.jconrel.2022.02.011_bb0470) 2019; 49
Holland (10.1016/j.jconrel.2022.02.011_bb0700) 2019; 8
Sahoo (10.1016/j.jconrel.2022.02.011_bb0730) 2020; 8
Vo (10.1016/j.jconrel.2022.02.011_bb0800) 2012; 64
Lee (10.1016/j.jconrel.2022.02.011_bb0390) 2015; 3
Yamamoto (10.1016/j.jconrel.2022.02.011_bb0340) 2013; 23
Bruno (10.1016/j.jconrel.2022.02.011_bb0045) 2013; 4
Choi (10.1016/j.jconrel.2022.02.011_bb0865) 2019; 8
Schwendeman (10.1016/j.jconrel.2022.02.011_bb0575) 2002; 19
Pande (10.1016/j.jconrel.2022.02.011_bb0555) 1983; 6
Ali (10.1016/j.jconrel.2022.02.011_bb0100) 2010
Pritchard (10.1016/j.jconrel.2022.02.011_bb0735) 2011; 8
Lu (10.1016/j.jconrel.2022.02.011_bb0675) 2009; 10
Li (10.1016/j.jconrel.2022.02.011_bb0935) 2015; 219
West (10.1016/j.jconrel.2022.02.011_bb0125) 2003; 285
Wang (10.1016/j.jconrel.2022.02.011_bb0920) 2019; 5
Dimitrov (10.1016/j.jconrel.2022.02.011_bb0075) 2012; 899
Zbikowska (10.1016/j.jconrel.2022.02.011_bb0435) 2006; 40
Hopkins (10.1016/j.jconrel.2022.02.011_bb0890) 2013; 23
Pond (10.1016/j.jconrel.2022.02.011_bb0105) 1984; 9
Patil (10.1016/j.jconrel.2022.02.011_bb0130) 2012; 29
Brooks (10.1016/j.jconrel.2022.02.011_bb0720) 2015; 3
Colombié (10.1016/j.jconrel.2022.02.011_bb0360) 2001; 28
Lankalapalli (10.1016/j.jconrel.2022.02.011_bb0265) 2009; 71
Abuhanoğlu (10.1016/j.jconrel.2022.02.011_bb0410) 2014; 6
Dong (10.1016/j.jconrel.2022.02.011_bb0725) 2015; 91
Huang (10.1016/j.jconrel.2022.02.011_bb0825) 2014; 88
Gong (10.1016/j.jconrel.2022.02.011_bb0790) 2019; 102
Wang (10.1016/j.jconrel.2022.02.011_bb0780) 2007; 117
Navone (10.1016/j.jconrel.2022.02.011_bb0695) 2014; 5
Bustamante-Marin (10.1016/j.jconrel.2022.02.011_bb0120) 2017; 9
Kundu (10.1016/j.jconrel.2022.02.011_bb0820) 2010; 388
Patel (10.1016/j.jconrel.2022.02.011_bb0085) 2014; 5
Nguyen (10.1016/j.jconrel.2022.02.011_bb0385) 2018; 129
Wang (10.1016/j.jconrel.2022.02.011_bb0845) 2008; 29
Meredith (10.1016/j.jconrel.2022.02.011_bb0135) 2015; 17
Giteau (10.1016/j.jconrel.2022.02.011_bb0585) 2008
Wongpinyochit (10.1016/j.jconrel.2022.02.011_bb0650) 2016; 116
Borgström (10.1016/j.jconrel.2022.02.011_bb0115) 2006; 19
Pappalardo (10.1016/j.jconrel.2022.02.011_bb0460) 2019; 20
Craik (10.1016/j.jconrel.2022.02.011_bb0050) 2013; 81
Wang (10.1016/j.jconrel.2022.02.011_bb0710) 2018; 6
Alkilani (10.1016/j.jconrel.2022.02.011_bb0150) 2015; 7
Faisant (10.1016/j.jconrel.2022.02.011_bb0425) 2003; 56
Böstman (10.1016/j.jconrel.2022.02.011_bb0540) 2000; 21
Kim (10.1016/j.jconrel.2022.02.011_bb0375) 2012; 64
Hino (10.1016/j.jconrel.2022.02.011_bb0775) 2000; 6
Dinis (10.1016/j.jconrel.2022.02.011_bb0835) 2014; 6
Tallury (10.1016/j.jconrel.2022.02.011_bb0570) 2007; 23
Wang (10.1016/j.jconrel.2022.02.011_bb0785) 2010; 31
Castel (10.1016/j.jconrel.2022.02.011_bb0550) 2015; 42
Heller (10.1016/j.jconrel.2022.02.011_bb0250) 1985; 2
Lyu (10.1016/j.jconrel.2022.02.011_bb0465) 2009; 10
Sung (10.1016/j.jconrel.2022.02.011_bb0270) 2020; 24
Athanasiou (10.1016/j.jconrel.2022.02.011_bb0415) 1996; 17
Kim (10.1016/j.jconrel.2022.02.011_bb0905) 2015; 15
Jain (10.1016/j.jconrel.2022.02.011_bb0260) 2008; 5
Tsioris (10.1016/j.jconrel.2022.02.011_bb0910) 2012; 22
Fu (10.1016/j.jconrel.2022.02.011_bb0565) 2010; 7
Numata (10.1016/j.jconrel.2022.02.011_bb0635) 2010; 62
Rosales (10.1016/j.jconrel.2022.02.011_bb0760) 2017
DeMuth (10.1016/j.jconrel.2022.02.011_bb0930) 2014; 3
Zhao (10.1016/j.jconrel.2022.02.011_bb0070) 2016; 4
Fisher (10.1016/j.jconrel.2022.02.011_bb0020) 2019; 33
Barui (10.1016/j.jconrel.2022.02.011_bb0335) 2018
Lalla (10.1016/j.jconrel.2022.02.011_bb0430) 1993; 10
Zhu (10.1016/j.jconrel.2022.02.011_bb0715) 2015; 135
Muttenthaler (10.1016/j.jconrel.2022.02.011_bb0040) 2021; 20
Yucel (10.1016/j.jconrel.2022.02.011_bb0875) 2010; 170
Thurber (10.1016/j.jconrel.2022.02.011_bb0495) 2015; 71
Muheem (10.1016/j.jconrel.2022.02.011_bb0055) 2016; 24
Lowinger (10.1016/j.jconrel.2022.02.011_bb0545) 2018; 10
(10.1016/j.jconrel.2022.02.011_bb0665) 1991
Yavuz (10.1016/j.jconrel.2022.02.011_bb0915) 2020; 3
DeMuth (10.1016/j.jconrel.2022.02.011_bb0380) 2013; 23
Montanari (10.1016/j.jconrel.2022.02.011_bb0420) 1998; 56
Rockwood (10.1016/j.jconrel.2022.02.011_bb0645) 2011; 6
Boopathy (10.1016/j.jconrel.2022.02.011_bb0925) 2019; 116
Li (10.1016/j.jconrel.2022.02.011_bb0620) 2021
L-T (10.1016/j.jconrel.2022.02.011_bb0515) 1989
Diab (10.1016/j.jconrel.2022.02.011_bb0885) 2012; 11
Li (10.1016/j.jconrel.2022.02.011_bb0810) 2017; 7
Lammel (10.1016/j.jconrel.2022.02.011_bb0805) 2010; 31
Hoare (10.1016/j.jconrel.2022.02.011_bb0370) 2008; 49
Guo (10.1016/j.jconrel.2022.02.011_bb0670) 2020; 19
Yucel (10.1016/j.jconrel.2022.02.011_bb0840) 2009; 97
Hu (10.1016/j.jconrel.2022.02.011_bb0660) 2011; 12
Khare (10.1016/j.jconrel.2022.02.011_bb0505) 1995; 16
Cao (10.1016/j.jconrel.2022.02.011_bb0605) 2009; 10
Zhao (10.1016/j.jconrel.2022.02.011_bb0255) 2003; 55
Carbinatto (10.1016/j.jconrel.2022.02.011_bb0510) 2014; 9
Bialik (10.1016/j.jconrel.2022.02.011_bb0245) 2019; 16
Shi (10.1016/j.jconrel.2022.02.011_bb0830) 2013; 14
Rnjak-Kovacina (10.1016/j.jconrel.2022.02.011_bb0680) 2015; 15
Lau (10.1016/j.jconrel.2022.02.011_bb0015) 2018; 26
Li (10.1016/j.jconrel.2022.02.011_bb0655) 2015; 219
Kamaly (10.1016/j.jconrel.2022.02.011_bb0445) 2016; 116
Cao (10.1016/j.jconrel.2022.02.011_bb0485) 2006; 27
Paudel (10.1016/j.jconrel.2022.02.011_bb0155) 2010; 1
Lee (10.1016/j.jconrel.2022.02.011_bb0280) 2016; 107
Yan (10.1016/j.jconrel.2022.02.011_bb0895) 2017; 11
Muheem (10.1016/j.jconrel.2022.02.011_bb0095) 2016; 24
Seib (10.1016/j.jconrel.2022.02.011_bb0640) 2013; 53
Vepari (10.1016/j.jconrel.2022.02.011_bb0600) 2007; 32
Choi (10.1016/j.jconrel.2022.02.011_bb0870) 2021
Dombu (10.1016/j.jconrel.2022.02.011_bb0145) 2013; 34
Prausnitz (10.1016/j.jconrel.2022.02.011_bb0160) 2008; 26
Koh (10.1016/j.jconrel.2022.02.011_bb0610) 2015; 46
da Luz (10.1016/j.jconrel.2022.02.011_bb0475) 2017; 15
Gajra (10.1016/j.jconrel.2022.02.011_bb0275) 2011; 4
References_xml – volume: 10
  start-page: 55
  year: 2018
  ident: bb0545
  article-title: Sustained Release Drug Delivery Applications of Polyurethanes
  publication-title: Pharmaceutics.
– volume: 30
  start-page: 257
  year: 2013
  end-page: 276
  ident: bb0520
  article-title: Poly(lactic-co-glycolic) acid-controlled-release systems: experimental and modeling insights
  publication-title: Crit. Rev. Ther. Drug Carrier Syst.
– volume: 19
  start-page: 73
  year: 2002
  end-page: 98
  ident: bb0575
  article-title: Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems
  publication-title: Crit. Rev. Ther. Drug Carrier Syst.
– volume: 15
  start-page: 11
  year: 2017
  ident: bb0475
  article-title: Poly-lactic acid nanoparticles (PLA-NP) promote physiological modifications in lung epithelial cells and are internalized by clathrin-coated pits and lipid rafts
  publication-title: J. Nanobiotechnol.
– volume: 10
  start-page: 1032
  year: 2009
  end-page: 1042
  ident: bb0675
  article-title: Stabilization of Enzymes in Silk Films
  publication-title: Biomacromolecules.
– volume: 3
  start-page: 65
  year: 2015
  ident: bb0720
  article-title: The potential of silk and silk-like proteins as natural mucoadhesive biopolymers for controlled drug delivery
  publication-title: Front. Chemi.
– volume: 91
  start-page: 82
  year: 2015
  end-page: 90
  ident: bb0725
  article-title: Fabrication and characterization of silk fibroin-coated liposomes for ocular drug delivery
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 3
  start-page: 47
  year: 2014
  end-page: 58
  ident: bb0930
  article-title: Implantable Silk Composite Microneedles for Programmable Vaccine Release Kinetics and Enhanced Immunogenicity in Transcutaneous Immunization
  publication-title: Adv. Healthcare Mater.
– volume: 10
  start-page: 4033
  year: 2009
  end-page: 4065
  ident: bb0465
  article-title: Degradability of polymers for implantable biomedical devices
  publication-title: Int. J. Mol. Sci.
– volume: 190
  start-page: 381
  year: 2014
  end-page: 397
  ident: bb0630
  article-title: Silk-based biomaterials for sustained drug delivery
  publication-title: J. Control. Release
– volume: 62
  start-page: 1497
  year: 2010
  end-page: 1508
  ident: bb0615
  article-title: Silk-based delivery systems of bioactive molecules
  publication-title: Adv. Drug Deliv. Rev.
– volume: 190
  start-page: 381
  year: 2014
  end-page: 397
  ident: bb0400
  article-title: Silk-based biomaterials for sustained drug delivery
  publication-title: J. Control. Release
– volume: 11
  start-page: 1937
  year: 2008
  ident: bb0815
  article-title: Biosynthesis of insulin-silk fibroin nanoparticles conjugates and in vitro evaluation of a drug delivery system
  publication-title: J. Nanopart. Res.
– volume: 170
  start-page: 406
  year: 2010
  end-page: 412
  ident: bb0875
  article-title: Non-equilibrium silk fibroin adhesives
  publication-title: J. Struct. Biol.
– volume: 20
  start-page: 1465
  year: 2019
  end-page: 1477
  ident: bb0460
  article-title: Biocompatibility of Resorbable Polymers: A Historical Perspective and Framework for the Future
  publication-title: Biomacromolecules.
– year: 2021
  ident: bb0870
  article-title: Silk hydrogels with controllable formation of dityrosine, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxyphenylalanine–fe3+ complexes through chitosan particle-assisted fenton reactions
  publication-title: Biomacromolecules.
– volume: 26
  start-page: 147
  year: 2005
  end-page: 155
  ident: bb0690
  article-title: The inflammatory responses to silk films in vitro and in vivo
  publication-title: Biomaterials.
– volume: 5
  start-page: 337
  year: 2014
  end-page: 365
  ident: bb0085
  article-title: Recent developments in protein and peptide parenteral delivery approaches
  publication-title: Ther. Deliv.
– volume: 31
  start-page: 4583
  year: 2010
  end-page: 4591
  ident: bb0805
  article-title: Controlling silk fibroin particle features for drug delivery
  publication-title: Biomaterials
– volume: 4
  start-page: 4060
  year: 2016
  end-page: 4071
  ident: bb0070
  article-title: Polymer-based nanoparticles for protein delivery: design, strategies and applications
  publication-title: J. Mater. Chem. B
– volume: 135
  start-page: 416
  year: 2015
  end-page: 424
  ident: bb0715
  article-title: A tubular gelatin scaffold capable of the time-dependent controlled release of epidermal growth factor and mitomycin C
  publication-title: Colloids Surf. B: Biointerfaces
– volume: 38
  start-page: 1318
  year: 2018
  end-page: 1329
  ident: bb0560
  article-title: Use of a lysine-derived urethane surgical adhesive as an alternative to progressive tension sutures in abdominoplasty patients: a Cohort study
  publication-title: Aesthet. Surg. J.
– volume: 97
  start-page: 2044
  year: 2009
  end-page: 2050
  ident: bb0840
  article-title: Vortex-induced injectable silk fibroin hydrogels
  publication-title: Biophys. J.
– volume: 26
  start-page: 1261
  year: 2008
  end-page: 1268
  ident: bb0160
  article-title: Transdermal drug delivery
  publication-title: Nat. Biotechnol.
– volume: 116
  start-page: 16473
  year: 2019
  end-page: 16478
  ident: bb0925
  article-title: Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination
  publication-title: Proc. Natl. Acad. Sci.
– start-page: 209
  year: 2010
  end-page: 246
  ident: bb0100
  article-title: CHAPTER 9 - Pulmonary Drug Delivery
  publication-title: Handbook of Non-Invasive Drug Delivery Systems
– volume: 10
  start-page: 449
  year: 1993
  end-page: 460
  ident: bb0430
  article-title: Biodegradable microspheres of poly (DL-lactic acid) containing piroxicam as a model drug for controlled release via the parenteral route
  publication-title: J. Microencapsul.
– volume: 19
  start-page: 102
  year: 2020
  end-page: 108
  ident: bb0670
  article-title: Thermoplastic moulding of regenerated silk
  publication-title: Nat. Mater.
– volume: 22
  start-page: 330
  year: 2012
  end-page: 335
  ident: bb0910
  article-title: Fabrication of silk microneedles for controlled-release drug delivery
  publication-title: Adv. Funct. Mater.
– year: 2008
  ident: bb0585
  article-title: How to Achieve Sustained and Complete Protein Release from PLGA-Based Microparticles
– volume: 64
  start-page: 1547
  year: 2012
  end-page: 1568
  ident: bb0375
  article-title: Microneedles for drug and vaccine delivery
  publication-title: Adv. Drug Deliv. Rev.
– volume: 388
  start-page: 242
  year: 2010
  end-page: 250
  ident: bb0820
  article-title: Silk fibroin nanoparticles for cellular uptake and control release
  publication-title: Int. J. Pharm.
– volume: 26
  start-page: 2700
  year: 2018
  end-page: 2707
  ident: bb0015
  article-title: Therapeutic peptides: Historical perspectives, current development trends, and future directions
  publication-title: Bioorg. Med. Chem.
– volume: 69
  start-page: 519
  year: 2008
  end-page: 526
  ident: bb0405
  article-title: γ-Irradiation effects on biopharmaceutical properties of PLGA microspheres loaded with SPf66 synthetic vaccine
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 46
  start-page: 86
  year: 2015
  end-page: 110
  ident: bb0610
  article-title: Structures, mechanical properties and applications of silk fibroin materials
  publication-title: Prog. Polym. Sci.
– volume: 6
  start-page: 2739
  year: 2018
  end-page: 2746
  ident: bb0710
  article-title: Bioactive silk hydrogels with tunable mechanical properties
  publication-title: J. Mater. Chem. B
– volume: 71
  start-page: 481
  year: 2009
  end-page: 487
  ident: bb0265
  article-title: Polyelectrolyte complexes: a review of their applicability in drug delivery technology
  publication-title: Indian J. Pharm. Sci.
– volume: 70
  start-page: 269
  year: 2008
  end-page: 277
  ident: bb0060
  article-title: Protein and Peptide drug delivery: oral approaches
  publication-title: Indian J. Pharm. Sci.
– volume: 17
  start-page: 780
  year: 2015
  end-page: 787
  ident: bb0140
  article-title: Intranasal delivery of proteins and peptides in the treatment of neurodegenerative diseases
  publication-title: AAPS J.
– volume: 2
  start-page: 167
  year: 1985
  end-page: 177
  ident: bb0250
  article-title: Controlled drug release from poly(ortho esters) — A surface eroding polymer
  publication-title: J. Control. Release
– volume: 14
  start-page: 4465
  year: 2013
  end-page: 4474
  ident: bb0830
  article-title: Silk fibroin-based complex particles with bioactive encrustation for bone morphogenetic protein 2 delivery
  publication-title: Biomacromolecules.
– volume: 29
  start-page: 1054
  year: 2008
  end-page: 1064
  ident: bb0845
  article-title: Sonication-induced gelation of silk fibroin for cell encapsulation
  publication-title: Biomaterials.
– volume: 12
  start-page: 301
  year: 2006
  end-page: 308
  ident: bb0530
  article-title: Polyglycolic acid-induced inflammation: role of hydrolysis and resulting complement activation
  publication-title: Tissue Eng.
– volume: 6
  start-page: 16817
  year: 2014
  end-page: 16826
  ident: bb0835
  article-title: Method to form a fiber/growth factor dual-gradient along electrospun silk for nerve regeneration
  publication-title: ACS Appl. Mater. Interfaces
– volume: 358
  start-page: 50
  year: 2008
  end-page: 59
  ident: bb0580
  article-title: Role of a novel multifunctional excipient poly(ethylene glycol)-block-oligo(vinyl sulfadimethoxine) in controlled release of lysozyme from PLGA microspheres
  publication-title: Int. J. Pharm.
– start-page: 9
  year: 1989
  end-page: 88
  ident: bb0515
  article-title: Diffusion-Controlled Release
  publication-title: Controlled Release: A Quantitative Treatment
– volume: 6
  start-page: 755
  year: 2014
  end-page: 774
  ident: bb0005
  article-title: Peptides and peptidomimetics as immunomodulators
  publication-title: Immunotherapy.
– volume: 7
  start-page: 438
  year: 2015
  end-page: 470
  ident: bb0150
  article-title: Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum
  publication-title: Pharmaceutics.
– volume: 7
  start-page: 767
  year: 2007
  end-page: 783
  ident: bb0345
  article-title: PLA nano- and microparticles for drug delivery: an overview of the methods of preparation
  publication-title: Macromol. Biosci.
– volume: 9
  start-page: 2764
  year: 2008
  end-page: 2774
  ident: bb0705
  article-title: Novel genipin-cross-linked chitosan/silk fibroin sponges for cartilage engineering strategies
  publication-title: Biomacromolecules.
– volume: 16
  start-page: 559
  year: 1995
  end-page: 567
  ident: bb0505
  article-title: Swelling/deswelling of anionic copolymer gels
  publication-title: Biomaterials.
– volume: 7
  start-page: 429
  year: 2010
  end-page: 444
  ident: bb0565
  article-title: Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems
  publication-title: Expert Opin Drug Deliv.
– volume: 21
  start-page: 1678
  year: 2020
  end-page: 1686
  ident: bb0595
  article-title: Enzymatic degradation of bombyx mori silk materials: a review
  publication-title: Biomacromolecules.
– volume: 31
  start-page: 1025
  year: 2010
  end-page: 1035
  ident: bb0785
  article-title: Silk nanospheres and microspheres from silk/pva blend films for drug delivery
  publication-title: Biomaterials.
– volume: 53
  start-page: 756
  year: 2013
  end-page: 766
  ident: bb0640
  article-title: Silk for drug delivery applications: opportunities and challenges
  publication-title: Israel J. Chem.
– volume: 33
  start-page: 9
  year: 2019
  end-page: 20
  ident: bb0020
  article-title: Peptide-Based Therapeutics for Oncology
  publication-title: Pharmaceut Med.
– volume: 24
  start-page: 4615
  year: 2014
  end-page: 4624
  ident: bb0860
  article-title: Highly Tunable Elastomeric Silk Biomaterials
  publication-title: Adv. Funct. Mater.
– volume: 55
  start-page: 483
  year: 2003
  end-page: 499
  ident: bb0255
  article-title: Polyphosphoesters in drug and gene delivery
  publication-title: Adv. Drug Deliv. Rev.
– volume: 40
  start-page: 536
  year: 2006
  end-page: 542
  ident: bb0435
  article-title: Protein modification caused by a high dose of gamma irradiation in cryo-sterilized plasma: Protective effects of ascorbate
  publication-title: Free Radic. Biol. Med.
– volume: 116
  start-page: 179
  year: 2015
  end-page: 186
  ident: bb0190
  article-title: Mucus as a Barrier to Drug Delivery – Understanding and Mimicking the Barrier Properties
  publication-title: Basic Clin. Pharmacol. Toxicol.
– volume: 5
  start-page: 1887
  year: 2019
  end-page: 1894
  ident: bb0920
  article-title: Insulin-loaded silk fibroin microneedles as sustained release system
  publication-title: ACS Biomater. Sci. Eng.
– volume: 899
  start-page: 1
  year: 2012
  end-page: 26
  ident: bb0075
  article-title: Therapeutic proteins
  publication-title: Methods Mol. Biol.
– volume: 29
  start-page: 44
  year: 2012
  end-page: 49
  ident: bb0130
  article-title: Pulmonary drug delivery strategies: A concise, systematic review
  publication-title: Lung India
– start-page: 55
  year: 2018
  end-page: 90
  ident: bb0335
  article-title: 3 - Synthetic polymeric gel
  publication-title: Polymeric Gels
– volume: 11
  start-page: 1280
  year: 2018
  ident: bb0795
  article-title: Porous silk fibroin microspheres sustainably releasing bioactive basic fibroblast growth factor
  publication-title: Materials.
– volume: 8
  start-page: 4176
  year: 2020
  end-page: 4185
  ident: bb0730
  article-title: Silk degumming time controls horseradish peroxidase-catalyzed hydrogel properties
  publication-title: Biomater. Sci.
– volume: 71
  start-page: 145
  year: 2015
  end-page: 157
  ident: bb0685
  article-title: In vivo bioresponses to silk proteins
  publication-title: Biomaterials.
– start-page: 20232017
  year: 2017
  ident: bb0035
  article-title: Protein therapeutics market by product (monoclonal antibodies, insulin, fusion protein, erythropoietin, interferon, human growth hormone, and follicle stimulating hormone) and application (metabolic disorders, immunologic disorders, hematological disorders, cancer, hormonal disorders, genetic disorders, and others) - global opportunity analysis and industry
  publication-title: Forecast
– volume: 56
  start-page: 271
  year: 2003
  end-page: 279
  ident: bb0425
  article-title: Mathematical modeling of drug release from bioerodible microparticles: effect of gamma-irradiation
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 17
  start-page: 93
  year: 1996
  end-page: 102
  ident: bb0415
  article-title: Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/ polyglycolic acid copolymers
  publication-title: Biomaterials.
– volume: 27
  start-page: 2854
  year: 2006
  end-page: 2864
  ident: bb0485
  article-title: The influence of architecture on degradation and tissue ingrowth into three-dimensional poly(lactic-co-glycolic acid) scaffolds in vitro and in vivo
  publication-title: Biomaterials.
– volume: 219
  start-page: 416
  year: 2015
  end-page: 430
  ident: bb0935
  article-title: Silk-based stabilization of biomacromolecules
  publication-title: J. Control. Release
– volume: 49
  start-page: 1993
  year: 2008
  end-page: 2007
  ident: bb0370
  article-title: Hydrogels in drug delivery: progress and challenges
  publication-title: Polymer.
– volume: 190
  start-page: 381
  year: 2014
  end-page: 397
  ident: bb0755
  article-title: Silk-based biomaterials for sustained drug delivery
  publication-title: J. Control. Release
– start-page: 9042851
  year: 2017
  ident: bb0760
  article-title: Phagocytosis: A Fundamental Process in Immunity
  publication-title: Biomed. Res. Int.
– volume: 42
  start-page: 186
  year: 2015
  end-page: 193
  ident: bb0550
  article-title: Polyurethane-coated breast implants revisited: a 30-year follow-up
  publication-title: Arch. Plast. Surg.
– volume: 23
  start-page: 404
  year: 2007
  end-page: 409
  ident: bb0570
  article-title: Poly (ethylene-co-vinyl acetate) copolymer matrix for delivery of chlorhexidine and acyclovir drugs for use in the oral environment: effect of drug combination, copolymer composition and coating on the drug release rate
  publication-title: Dent. Mater.
– volume: 12
  start-page: 1686
  year: 2011
  end-page: 1696
  ident: bb0660
  article-title: Regulation of silk material structure by temperature-controlled water vapor annealing
  publication-title: Biomacromolecules.
– volume: 59
  start-page: 450
  year: 2002
  end-page: 459
  ident: bb0455
  article-title: Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium
  publication-title: J. Biomed. Mater. Res.
– volume: 116
  start-page: 2602
  year: 2016
  end-page: 2663
  ident: bb0445
  article-title: Degradable Controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release
  publication-title: Chem. Rev.
– start-page: 2105196
  year: 2021
  ident: bb0620
  article-title: Fiber-based biopolymer processing as a route toward sustainability
  publication-title: Adv. Mater.
– volume: 97
  start-page: 2497
  year: 2008
  end-page: 2523
  ident: bb0080
  article-title: Past, present, and future technologies for oral delivery of therapeutic proteins
  publication-title: J. Pharm. Sci.
– volume: 34
  start-page: 516
  year: 2013
  end-page: 525
  ident: bb0145
  article-title: Airway delivery of peptides and proteins using nanoparticles
  publication-title: Biomaterials.
– volume: 9
  year: 2017
  ident: bb0120
  article-title: Cilia and mucociliary clearance
  publication-title: Cold Spring Harb. Perspect. Biol.
– volume: 6
  start-page: 51
  year: 2014
  end-page: 60
  ident: bb0410
  article-title: Radiation sterilization of new drug delivery systems
  publication-title: Interv Med Appl Sci.
– volume: 5
  start-page: 7
  year: 2014
  ident: bb0695
  article-title: Decellularized silk fibroin scaffold primed with adipose mesenchymal stromal cells improves wound healing in diabetic mice
  publication-title: Stem Cell Res Ther
– volume: 11
  start-page: 3168
  year: 2017
  end-page: 3177
  ident: bb0895
  article-title: Core-shell silk hydrogels with spatially tuned conformations as drug-delivery system
  publication-title: J. Tissue Eng. Regen. Med.
– volume: 81
  start-page: 136
  year: 2013
  end-page: 147
  ident: bb0050
  article-title: The future of peptide-based drugs
  publication-title: Chem. Biol. Drug Des.
– volume: 11
  start-page: 643
  year: 2010
  end-page: 647
  ident: bb0765
  article-title: Generation of monodisperse silk microspheres prepared with microfluidics
  publication-title: Biomacromolecules.
– volume: 32
  start-page: 991
  year: 2007
  end-page: 1007
  ident: bb0600
  article-title: Silk as a Biomaterial
  publication-title: Prog. Polym. Sci.
– volume: 24
  start-page: 413
  year: 2016
  end-page: 428
  ident: bb0095
  article-title: A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
  publication-title: Saudi Pharm J.
– volume: 1
  start-page: 149
  year: 2010
  end-page: 173
  ident: bb0065
  article-title: Polymers for drug delivery systems
  publication-title: Annu Rev Chem Biomol Eng.
– volume: 56
  start-page: 219
  year: 1998
  end-page: 229
  ident: bb0420
  article-title: Gamma irradiation effects on poly(dl-lactictide-co-glycolide) microspheres
  publication-title: J. Control. Release
– volume: 64
  start-page: 1292
  year: 2012
  end-page: 1309
  ident: bb0800
  article-title: Strategies for controlled delivery of growth factors and cells for bone regeneration
  publication-title: Adv. Drug Deliv. Rev.
– volume: 12
  start-page: 804
  year: 2011
  end-page: 812
  ident: bb0750
  article-title: Mechanisms of controlled release from silk fibroin films
  publication-title: Biomacromolecules.
– volume: 6
  start-page: 1612
  year: 2011
  end-page: 1631
  ident: bb0645
  article-title: Materials fabrication from Bombyx mori silk fibroin
  publication-title: Nat. Protoc.
– volume: 17
  start-page: 93
  year: 1996
  end-page: 102
  ident: bb0535
  article-title: Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers
  publication-title: Biomaterials.
– volume: 107
  start-page: 153
  year: 2016
  end-page: 162
  ident: bb0450
  article-title: Biocompatibility and safety of PLA and its copolymers
  publication-title: Adv. Drug Deliv. Rev.
– volume: 107
  start-page: 153
  year: 2016
  end-page: 162
  ident: bb0480
  article-title: Biocompatibility and safety of PLA and its copolymers
  publication-title: Adv. Drug Deliv. Rev.
– volume: 5
  start-page: 889
  year: 2008
  end-page: 907
  ident: bb0260
  article-title: Polyanhydrides as localized drug delivery carrier: an update
  publication-title: Expert Opin. Drug Delivery.
– volume: 116
  start-page: 54669
  year: 2016
  ident: bb0650
  article-title: Manufacture and Drug Delivery Applications of Silk Nanoparticles
  publication-title: J. Vis. Exp.
– volume: 9
  start-page: 27
  year: 2014
  end-page: 34
  ident: bb0510
  article-title: Insights into the swelling process and drug release mechanisms from cross-linked pectin/high amylose starch matrices
  publication-title: Asian J. Pharmac. Sci.
– volume: 4
  start-page: 20
  year: 2011
  end-page: 26
  ident: bb0275
  article-title: Poly vinyl alcohol hydrogel and its pharmaceutical and biomedical applications: a review
  publication-title: Int. J. Pharmaceut. Res.
– volume: 20
  start-page: 130
  year: 2008
  end-page: 136
  ident: bb0490
  article-title: Effects of biomaterial-induced inflammation on fibrosis and rejection
  publication-title: Semin. Immunol.
– volume: 17
  start-page: 780
  year: 2015
  end-page: 787
  ident: bb0135
  article-title: Intranasal delivery of proteins and peptides in the treatment of neurodegenerative diseases
  publication-title: AAPS J.
– volume: 3
  start-page: 43
  year: 2019
  ident: bb0325
  article-title: Surface modification of 3D printed PLA objects by fused deposition modeling: a review
  publication-title: Colloids Interf.
– volume: 16
  start-page: 953
  year: 2019
  end-page: 967
  ident: bb0245
  article-title: Biodegradable synthetic polyesters in the technology of controlled dosage forms of antihypertensive drugs – the overview
  publication-title: Expert Opin. Drug Delivery.
– volume: 17
  start-page: 2351
  year: 1996
  end-page: 2356
  ident: bb0500
  article-title: Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas
  publication-title: Biomaterials.
– volume: 129
  start-page: 88
  year: 2018
  end-page: 103
  ident: bb0385
  article-title: Poly (vinyl alcohol) microneedles: Fabrication, characterization, and application for transdermal drug delivery of doxorubicin
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 160
  start-page: 186
  year: 2020
  end-page: 198
  ident: bb0625
  article-title: Bioengineered elastin- and silk-biomaterials for drug and gene delivery
  publication-title: Adv. Drug Deliv. Rev.
– volume: 8
  start-page: 15902
  year: 2017
  ident: bb0770
  article-title: Silk micrococoons for protein stabilisation and molecular encapsulation
  publication-title: Nat. Commun.
– volume: 49
  start-page: 347
  year: 2019
  end-page: 380
  ident: bb0470
  article-title: Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles
  publication-title: J. Pharmac. Investigat.
– volume: 7
  start-page: 56550
  year: 2017
  end-page: 56558
  ident: bb0810
  article-title: Fabrication of aqueous-based dual drug loaded silk fibroin electrospun nanofibers embedded with curcumin-loaded RSF nanospheres for drugs controlled release
  publication-title: RSC Adv.
– volume: 15
  year: 2015
  ident: bb0905
  article-title: Curved microneedle array-based sEMG electrode for robust long-term measurements and high selectivity
  publication-title: Sensors.
– volume: 62
  start-page: 1497
  year: 2010
  end-page: 1508
  ident: bb0635
  article-title: Silk-based delivery systems of bioactive molecules
  publication-title: Adv. Drug Deliv. Rev.
– volume: 21
  start-page: 1102
  year: 2014
  end-page: 1120
  ident: bb0240
  article-title: Recent advances in protein and Peptide drug delivery: a special emphasis on polymeric nanoparticles
  publication-title: Protein Pept. Lett.
– volume: 24
  start-page: 12
  year: 2020
  ident: bb0270
  article-title: Recent advances in polymeric drug delivery systems
  publication-title: Biomater. Res.
– volume: 28
  start-page: 820
  year: 2001
  end-page: 826
  ident: bb0360
  article-title: Lysozyme inactivation under mechanical stirring: effect of physical and molecular interfaces
  publication-title: Enzym. Microb. Technol.
– volume: 23
  start-page: 1218
  year: 2007
  end-page: 1222
  ident: bb0355
  article-title: Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment
  publication-title: Biotechnol. Prog.
– volume: 58
  start-page: 977
  year: 2009
  end-page: 987
  ident: bb0010
  article-title: Novel peptide therapeutics for treatment of infections
  publication-title: J. Med. Microbiol.
– volume: 50
  start-page: 27
  year: 2000
  end-page: 46
  ident: bb0745
  article-title: Hydrogels in pharmaceutical formulations
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 17
  start-page: 1290
  year: 2019
  end-page: 1308
  ident: bb0090
  article-title: Recent advancements in non-invasive formulations for protein drug delivery
  publication-title: Comput Struct Biotechnol J.
– volume: 1
  start-page: 109
  year: 2010
  end-page: 131
  ident: bb0155
  article-title: Challenges and opportunities in dermal/transdermal delivery
  publication-title: Ther. Deliv.
– volume: 6
  start-page: 335
  year: 2000
  end-page: 339
  ident: bb0775
  article-title: Silk microspheres prepared by spray-drying of an aqueous system
  publication-title: Pharm. Pharmacol. Commun.
– volume: 24
  start-page: 413
  year: 2016
  end-page: 428
  ident: bb0055
  article-title: A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
  publication-title: Saudi Pharmaceut. J.
– volume: 23
  start-page: 129
  year: 2013
  end-page: 135
  ident: bb0340
  article-title: Hydrophobized poly(vinyl alcohol) for encapsulation of amphotericin B in nanoparticles
  publication-title: J. Drug Deliv. Sci. Technol.
– volume: 34
  start-page: 7766
  year: 2013
  end-page: 7775
  ident: bb0900
  article-title: Mechanisms of monoclonal antibody stabilization and release from silk biomaterials
  publication-title: Biomaterials
– volume: 23
  start-page: 5140
  year: 2013
  end-page: 5149
  ident: bb0890
  article-title: Silk hydrogels as soft substrates for neural tissue engineering
  publication-title: Adv. Funct. Mater.
– volume: 107
  start-page: 176
  year: 2016
  end-page: 191
  ident: bb0280
  article-title: PLA micro- and nano-particles
  publication-title: Adv. Drug Deliv. Rev.
– volume: 9
  start-page: 1
  year: 1984
  end-page: 25
  ident: bb0105
  article-title: First-pass elimination. Basic concepts and clinical consequences
  publication-title: Clin. Pharmacokinet.
– volume: 19
  start-page: 473
  year: 2006
  end-page: 483
  ident: bb0115
  article-title: Degree of throat deposition can explain the variability in lung deposition of inhaled drugs
  publication-title: J Aerosol Med.
– volume: 8
  start-page: 1900644
  year: 2019
  ident: bb0865
  article-title: Silk hydrogels crosslinked by the fenton reaction
  publication-title: Adv. Healthcare Mater.
– volume: 4
  year: 2016
  ident: bb0590
  article-title: Chemically modified peptides and proteins - critical considerations for oral delivery
  publication-title: Tissue Barriers.
– volume: 6
  start-page: 858
  year: 1983
  end-page: 867
  ident: bb0555
  article-title: Thermoplastic polyurethanes as insulating materials for long-life cardiac pacing leads
  publication-title: Pacing Clin. Electrophysiol.
– volume: 26
  start-page: 3385
  year: 2005
  end-page: 3393
  ident: bb0740
  article-title: In vitro degradation of silk fibroin
  publication-title: Biomaterials.
– volume: 6
  start-page: 113
  year: 2017
  ident: bb0025
  article-title: Recent advances in (therapeutic protein) drug development
  publication-title: F1000Res
– volume: 8
  start-page: 797
  year: 2011
  end-page: 811
  ident: bb0735
  article-title: Silk fibroin biomaterials for controlled release drug delivery
  publication-title: Expert Opin Drug Deliv.
– volume: 3
  start-page: 276
  year: 2015
  end-page: 285
  ident: bb0390
  article-title: Fabrication of a novel partially dissolving polymer microneedle patch for transdermal drug delivery
  publication-title: J. Mater. Chem. B
– volume: 3
  start-page: 1900140
  year: 2020
  ident: bb0395
  article-title: Biomedical applications of polymeric microneedles for transdermal therapeutic delivery and diagnosis: current status and future perspectives
  publication-title: Adv.Therapeut.
– volume: 21
  start-page: 2615
  year: 2000
  end-page: 2621
  ident: bb0540
  article-title: Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review
  publication-title: Biomaterials.
– volume: 3
  start-page: 111
  year: 1981
  end-page: 118
  ident: bb0350
  article-title: Shear effects on enzymes
  publication-title: Enzym. Microb. Technol.
– volume: 22
  start-page: 711
  year: 2010
  end-page: 715
  ident: bb0850
  article-title: Electrogelation for Protein Adhesives
  publication-title: Adv. Mater.
– volume: 102
  start-page: 820
  year: 2019
  end-page: 828
  ident: bb0790
  article-title: Control of octreotide release from silk fibroin microspheres
  publication-title: Mater. Sci. Eng. C
– volume: 4
  start-page: 1443
  year: 2013
  end-page: 1467
  ident: bb0045
  article-title: Basics and recent advances in peptide and protein drug delivery
  publication-title: Ther. Deliv.
– volume: 285
  year: 2003
  ident: bb0125
  article-title: Thoughts on the pulmonary blood-gas barrier
  publication-title: Am. J. Phys. Lung Cell. Mol. Phys.
– volume: 88
  start-page: 104
  year: 2014
  end-page: 115
  ident: bb0825
  article-title: A novel technology using transscleral ultrasound to deliver protein loaded nanoparticles
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 71
  start-page: 145
  year: 2015
  end-page: 157
  ident: bb0495
  article-title: In vivo bioresponses to silk proteins
  publication-title: Biomaterials.
– volume: 10
  start-page: 1514
  year: 2009
  end-page: 1524
  ident: bb0605
  article-title: Biodegradation of silk biomaterials
  publication-title: Int. J. Mol. Sci.
– volume: 95
  start-page: 271
  year: 2015
  end-page: 278
  ident: bb0880
  article-title: Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 8
  start-page: 647
  year: 2017
  end-page: 661
  ident: bb0110
  article-title: Drug delivery to the lungs: challenges and opportunities
  publication-title: Ther. Deliv.
– volume: 8
  start-page: 1800465
  year: 2019
  ident: bb0700
  article-title: The biomedical use of silk: past, present, future
  publication-title: Adv. Healthcare Mater.
– volume: 219
  start-page: 416
  year: 2015
  end-page: 430
  ident: bb0655
  article-title: Silk-based stabilization of biomacromolecules
  publication-title: J. Control. Release
– volume: 117
  start-page: 360
  year: 2007
  end-page: 370
  ident: bb0780
  article-title: Silk microspheres for encapsulation and controlled release
  publication-title: J. Control. Release
– volume: 1
  start-page: 16071
  year: 2016
  ident: bb0365
  article-title: Designing hydrogels for controlled drug delivery
  publication-title: Nat Rev Mater.
– year: 1991
  ident: bb0665
  publication-title: Material Science and the Production of Shelf Stable Biologicals
– volume: 11
  start-page: 123
  year: 2012
  end-page: 131
  ident: bb0885
  article-title: A silk hydrogel-based delivery system of bone morphogenetic protein for the treatment of large bone defects
  publication-title: J. Mech. Behav. Biomed. Mater.
– volume: 20
  start-page: 309
  year: 2021
  end-page: 325
  ident: bb0040
  article-title: Trends in peptide drug discovery
  publication-title: Nat. Rev. Drug Discov.
– volume: 15
  start-page: 861
  year: 2015
  end-page: 874
  ident: bb0680
  article-title: The effect of sterilization on silk fibroin biomaterial properties
  publication-title: Macromol. Biosci.
– volume: 23
  start-page: 161
  year: 2013
  end-page: 172
  ident: bb0380
  article-title: Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination
  publication-title: Adv. Funct. Mater.
– volume: 28
  start-page: 339
  year: 2020
  end-page: 355
  ident: bb0030
  article-title: Protein drug delivery: current dosage form profile and formulation strategies
  publication-title: J. Drug Target.
– volume: 232
  year: 2020
  ident: bb0855
  article-title: Enzymatically crosslinked silk and silk-gelatin hydrogels with tunable gelation kinetics, mechanical properties and bioactivity for cell culture and encapsulation
  publication-title: Biomaterials.
– volume: 3
  start-page: 5375
  year: 2020
  end-page: 5382
  ident: bb0915
  article-title: Silk fibroin microneedle patches for the sustained release of levonorgestrel
  publication-title: ACS Appl. Bio Mater.
– volume: 6
  start-page: 1612
  issue: 10
  year: 2011
  ident: 10.1016/j.jconrel.2022.02.011_bb0645
  article-title: Materials fabrication from Bombyx mori silk fibroin
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2011.379
– volume: 19
  start-page: 473
  issue: 4
  year: 2006
  ident: 10.1016/j.jconrel.2022.02.011_bb0115
  article-title: Degree of throat deposition can explain the variability in lung deposition of inhaled drugs
  publication-title: J Aerosol Med.
  doi: 10.1089/jam.2006.19.473
– volume: 23
  start-page: 129
  issue: 2
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0340
  article-title: Hydrophobized poly(vinyl alcohol) for encapsulation of amphotericin B in nanoparticles
  publication-title: J. Drug Deliv. Sci. Technol.
  doi: 10.1016/S1773-2247(13)50020-7
– volume: 55
  start-page: 483
  issue: 4
  year: 2003
  ident: 10.1016/j.jconrel.2022.02.011_bb0255
  article-title: Polyphosphoesters in drug and gene delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(03)00040-1
– volume: 4
  issue: 2
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0590
  article-title: Chemically modified peptides and proteins - critical considerations for oral delivery
  publication-title: Tissue Barriers.
  doi: 10.1080/21688370.2016.1156805
– volume: 71
  start-page: 481
  issue: 5
  year: 2009
  ident: 10.1016/j.jconrel.2022.02.011_bb0265
  article-title: Polyelectrolyte complexes: a review of their applicability in drug delivery technology
  publication-title: Indian J. Pharm. Sci.
  doi: 10.4103/0250-474X.58165
– volume: 56
  start-page: 271
  issue: 2
  year: 2003
  ident: 10.1016/j.jconrel.2022.02.011_bb0425
  article-title: Mathematical modeling of drug release from bioerodible microparticles: effect of gamma-irradiation
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/S0939-6411(03)00104-8
– volume: 6
  start-page: 335
  issue: 8
  year: 2000
  ident: 10.1016/j.jconrel.2022.02.011_bb0775
  article-title: Silk microspheres prepared by spray-drying of an aqueous system
  publication-title: Pharm. Pharmacol. Commun.
  doi: 10.1211/146080800128736169
– volume: 58
  start-page: 977
  issue: Pt 8
  year: 2009
  ident: 10.1016/j.jconrel.2022.02.011_bb0010
  article-title: Novel peptide therapeutics for treatment of infections
  publication-title: J. Med. Microbiol.
  doi: 10.1099/jmm.0.011122-0
– volume: 4
  start-page: 20
  year: 2011
  ident: 10.1016/j.jconrel.2022.02.011_bb0275
  article-title: Poly vinyl alcohol hydrogel and its pharmaceutical and biomedical applications: a review
  publication-title: Int. J. Pharmaceut. Res.
– volume: 69
  start-page: 519
  issue: 2
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0405
  article-title: γ-Irradiation effects on biopharmaceutical properties of PLGA microspheres loaded with SPf66 synthetic vaccine
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2007.12.014
– volume: 22
  start-page: 330
  issue: 2
  year: 2012
  ident: 10.1016/j.jconrel.2022.02.011_bb0910
  article-title: Fabrication of silk microneedles for controlled-release drug delivery
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.201102012
– volume: 97
  start-page: 2497
  issue: 7
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0080
  article-title: Past, present, and future technologies for oral delivery of therapeutic proteins
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.21183
– volume: 17
  start-page: 780
  issue: 4
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0140
  article-title: Intranasal delivery of proteins and peptides in the treatment of neurodegenerative diseases
  publication-title: AAPS J.
  doi: 10.1208/s12248-015-9719-7
– volume: 11
  start-page: 123
  year: 2012
  ident: 10.1016/j.jconrel.2022.02.011_bb0885
  article-title: A silk hydrogel-based delivery system of bone morphogenetic protein for the treatment of large bone defects
  publication-title: J. Mech. Behav. Biomed. Mater.
  doi: 10.1016/j.jmbbm.2011.11.007
– volume: 62
  start-page: 1497
  issue: 15
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0615
  article-title: Silk-based delivery systems of bioactive molecules
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2010.03.009
– volume: 81
  start-page: 136
  issue: 1
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0050
  article-title: The future of peptide-based drugs
  publication-title: Chem. Biol. Drug Des.
  doi: 10.1111/cbdd.12055
– volume: 102
  start-page: 820
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0790
  article-title: Control of octreotide release from silk fibroin microspheres
  publication-title: Mater. Sci. Eng. C
  doi: 10.1016/j.msec.2019.05.004
– volume: 388
  start-page: 242
  issue: 1
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0820
  article-title: Silk fibroin nanoparticles for cellular uptake and control release
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2009.12.052
– volume: 6
  start-page: 858
  issue: 5 Pt 1
  year: 1983
  ident: 10.1016/j.jconrel.2022.02.011_bb0555
  article-title: Thermoplastic polyurethanes as insulating materials for long-life cardiac pacing leads
  publication-title: Pacing Clin. Electrophysiol.
  doi: 10.1111/j.1540-8159.1983.tb04406.x
– volume: 24
  start-page: 413
  issue: 4
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0095
  article-title: A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
  publication-title: Saudi Pharm J.
  doi: 10.1016/j.jsps.2014.06.004
– volume: 3
  start-page: 43
  issue: 2
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0325
  article-title: Surface modification of 3D printed PLA objects by fused deposition modeling: a review
  publication-title: Colloids Interf.
  doi: 10.3390/colloids3020043
– start-page: 9042851
  year: 2017
  ident: 10.1016/j.jconrel.2022.02.011_bb0760
  article-title: Phagocytosis: A Fundamental Process in Immunity
  publication-title: Biomed. Res. Int.
– volume: 219
  start-page: 416
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0935
  article-title: Silk-based stabilization of biomacromolecules
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.09.037
– volume: 4
  start-page: 4060
  issue: 23
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0070
  article-title: Polymer-based nanoparticles for protein delivery: design, strategies and applications
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C6TB00308G
– volume: 34
  start-page: 7766
  issue: 31
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0900
  article-title: Mechanisms of monoclonal antibody stabilization and release from silk biomaterials
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.06.039
– volume: 14
  start-page: 4465
  issue: 12
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0830
  article-title: Silk fibroin-based complex particles with bioactive encrustation for bone morphogenetic protein 2 delivery
  publication-title: Biomacromolecules.
  doi: 10.1021/bm401381s
– volume: 3
  start-page: 47
  issue: 1
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0930
  article-title: Implantable Silk Composite Microneedles for Programmable Vaccine Release Kinetics and Enhanced Immunogenicity in Transcutaneous Immunization
  publication-title: Adv. Healthcare Mater.
  doi: 10.1002/adhm.201300139
– volume: 1
  start-page: 16071
  issue: 12
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0365
  article-title: Designing hydrogels for controlled drug delivery
  publication-title: Nat Rev Mater.
  doi: 10.1038/natrevmats.2016.71
– volume: 4
  start-page: 1443
  issue: 11
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0045
  article-title: Basics and recent advances in peptide and protein drug delivery
  publication-title: Ther. Deliv.
  doi: 10.4155/tde.13.104
– volume: 29
  start-page: 44
  issue: 1
  year: 2012
  ident: 10.1016/j.jconrel.2022.02.011_bb0130
  article-title: Pulmonary drug delivery strategies: A concise, systematic review
  publication-title: Lung India
  doi: 10.4103/0970-2113.92361
– volume: 232
  year: 2020
  ident: 10.1016/j.jconrel.2022.02.011_bb0855
  article-title: Enzymatically crosslinked silk and silk-gelatin hydrogels with tunable gelation kinetics, mechanical properties and bioactivity for cell culture and encapsulation
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2019.119720
– volume: 116
  start-page: 16473
  issue: 33
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0925
  article-title: Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.1902179116
– volume: 64
  start-page: 1292
  issue: 12
  year: 2012
  ident: 10.1016/j.jconrel.2022.02.011_bb0800
  article-title: Strategies for controlled delivery of growth factors and cells for bone regeneration
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2012.01.016
– volume: 11
  start-page: 1937
  issue: 8
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0815
  article-title: Biosynthesis of insulin-silk fibroin nanoparticles conjugates and in vitro evaluation of a drug delivery system
  publication-title: J. Nanopart. Res.
  doi: 10.1007/s11051-008-9549-y
– volume: 107
  start-page: 153
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0450
  article-title: Biocompatibility and safety of PLA and its copolymers
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2016.03.012
– volume: 17
  start-page: 2351
  issue: 24
  year: 1996
  ident: 10.1016/j.jconrel.2022.02.011_bb0500
  article-title: Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas
  publication-title: Biomaterials.
  doi: 10.1016/S0142-9612(96)00076-2
– volume: 91
  start-page: 82
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0725
  article-title: Fabrication and characterization of silk fibroin-coated liposomes for ocular drug delivery
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2015.01.018
– volume: 64
  start-page: 1547
  issue: 14
  year: 2012
  ident: 10.1016/j.jconrel.2022.02.011_bb0375
  article-title: Microneedles for drug and vaccine delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2012.04.005
– volume: 6
  start-page: 2739
  issue: 18
  year: 2018
  ident: 10.1016/j.jconrel.2022.02.011_bb0710
  article-title: Bioactive silk hydrogels with tunable mechanical properties
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C8TB00607E
– volume: 24
  start-page: 4615
  issue: 29
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0860
  article-title: Highly Tunable Elastomeric Silk Biomaterials
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.201400526
– volume: 97
  start-page: 2044
  issue: 7
  year: 2009
  ident: 10.1016/j.jconrel.2022.02.011_bb0840
  article-title: Vortex-induced injectable silk fibroin hydrogels
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2009.07.028
– volume: 5
  start-page: 889
  issue: 8
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0260
  article-title: Polyanhydrides as localized drug delivery carrier: an update
  publication-title: Expert Opin. Drug Delivery.
  doi: 10.1517/17425247.5.8.889
– volume: 38
  start-page: 1318
  issue: 12
  year: 2018
  ident: 10.1016/j.jconrel.2022.02.011_bb0560
  article-title: Use of a lysine-derived urethane surgical adhesive as an alternative to progressive tension sutures in abdominoplasty patients: a Cohort study
  publication-title: Aesthet. Surg. J.
  doi: 10.1093/asj/sjy094
– volume: 5
  start-page: 1887
  issue: 4
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0920
  article-title: Insulin-loaded silk fibroin microneedles as sustained release system
  publication-title: ACS Biomater. Sci. Eng.
  doi: 10.1021/acsbiomaterials.9b00229
– start-page: 2105196
  year: 2021
  ident: 10.1016/j.jconrel.2022.02.011_bb0620
  article-title: Fiber-based biopolymer processing as a route toward sustainability
  publication-title: Adv. Mater.
– volume: 16
  start-page: 559
  issue: 7
  year: 1995
  ident: 10.1016/j.jconrel.2022.02.011_bb0505
  article-title: Swelling/deswelling of anionic copolymer gels
  publication-title: Biomaterials.
  doi: 10.1016/0142-9612(95)91130-Q
– volume: 31
  start-page: 1025
  issue: 6
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0785
  article-title: Silk nanospheres and microspheres from silk/pva blend films for drug delivery
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2009.11.002
– year: 2021
  ident: 10.1016/j.jconrel.2022.02.011_bb0870
  article-title: Silk hydrogels with controllable formation of dityrosine, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxyphenylalanine–fe3+ complexes through chitosan particle-assisted fenton reactions
  publication-title: Biomacromolecules.
– volume: 3
  start-page: 111
  issue: 2
  year: 1981
  ident: 10.1016/j.jconrel.2022.02.011_bb0350
  article-title: Shear effects on enzymes
  publication-title: Enzym. Microb. Technol.
  doi: 10.1016/0141-0229(81)90068-5
– volume: 10
  start-page: 55
  issue: 2
  year: 2018
  ident: 10.1016/j.jconrel.2022.02.011_bb0545
  article-title: Sustained Release Drug Delivery Applications of Polyurethanes
  publication-title: Pharmaceutics.
  doi: 10.3390/pharmaceutics10020055
– volume: 46
  start-page: 86
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0610
  article-title: Structures, mechanical properties and applications of silk fibroin materials
  publication-title: Prog. Polym. Sci.
  doi: 10.1016/j.progpolymsci.2015.02.001
– volume: 15
  start-page: 11
  issue: 1
  year: 2017
  ident: 10.1016/j.jconrel.2022.02.011_bb0475
  article-title: Poly-lactic acid nanoparticles (PLA-NP) promote physiological modifications in lung epithelial cells and are internalized by clathrin-coated pits and lipid rafts
  publication-title: J. Nanobiotechnol.
  doi: 10.1186/s12951-016-0238-1
– volume: 23
  start-page: 161
  issue: 2
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0380
  article-title: Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.201201512
– start-page: 55
  year: 2018
  ident: 10.1016/j.jconrel.2022.02.011_bb0335
  article-title: 3 - Synthetic polymeric gel
– volume: 21
  start-page: 1678
  issue: 5
  year: 2020
  ident: 10.1016/j.jconrel.2022.02.011_bb0595
  article-title: Enzymatic degradation of bombyx mori silk materials: a review
  publication-title: Biomacromolecules.
  doi: 10.1021/acs.biomac.0c00090
– volume: 20
  start-page: 1465
  issue: 4
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0460
  article-title: Biocompatibility of Resorbable Polymers: A Historical Perspective and Framework for the Future
  publication-title: Biomacromolecules.
  doi: 10.1021/acs.biomac.9b00159
– start-page: 20232017
  year: 2017
  ident: 10.1016/j.jconrel.2022.02.011_bb0035
  publication-title: Forecast
– volume: 9
  start-page: 2764
  issue: 10
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0705
  article-title: Novel genipin-cross-linked chitosan/silk fibroin sponges for cartilage engineering strategies
  publication-title: Biomacromolecules.
  doi: 10.1021/bm800874q
– volume: 6
  start-page: 113
  year: 2017
  ident: 10.1016/j.jconrel.2022.02.011_bb0025
  article-title: Recent advances in (therapeutic protein) drug development
  publication-title: F1000Res
  doi: 10.12688/f1000research.9970.1
– volume: 170
  start-page: 406
  issue: 2
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0875
  article-title: Non-equilibrium silk fibroin adhesives
  publication-title: J. Struct. Biol.
  doi: 10.1016/j.jsb.2009.12.012
– volume: 17
  start-page: 780
  issue: 4
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0135
  article-title: Intranasal delivery of proteins and peptides in the treatment of neurodegenerative diseases
  publication-title: AAPS J.
  doi: 10.1208/s12248-015-9719-7
– volume: 49
  start-page: 347
  issue: 4
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0470
  article-title: Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles
  publication-title: J. Pharmac. Investigat.
  doi: 10.1007/s40005-019-00439-x
– volume: 26
  start-page: 147
  issue: 2
  year: 2005
  ident: 10.1016/j.jconrel.2022.02.011_bb0690
  article-title: The inflammatory responses to silk films in vitro and in vivo
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2004.02.047
– volume: 8
  start-page: 1900644
  issue: 17
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0865
  article-title: Silk hydrogels crosslinked by the fenton reaction
  publication-title: Adv. Healthcare Mater.
  doi: 10.1002/adhm.201900644
– volume: 899
  start-page: 1
  year: 2012
  ident: 10.1016/j.jconrel.2022.02.011_bb0075
  article-title: Therapeutic proteins
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-61779-921-1_1
– volume: 129
  start-page: 88
  year: 2018
  ident: 10.1016/j.jconrel.2022.02.011_bb0385
  article-title: Poly (vinyl alcohol) microneedles: Fabrication, characterization, and application for transdermal drug delivery of doxorubicin
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2018.05.017
– volume: 23
  start-page: 1218
  issue: 5
  year: 2007
  ident: 10.1016/j.jconrel.2022.02.011_bb0355
  article-title: Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment
  publication-title: Biotechnol. Prog.
– volume: 219
  start-page: 416
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0655
  article-title: Silk-based stabilization of biomacromolecules
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.09.037
– volume: 30
  start-page: 257
  issue: 3
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0520
  article-title: Poly(lactic-co-glycolic) acid-controlled-release systems: experimental and modeling insights
  publication-title: Crit. Rev. Ther. Drug Carrier Syst.
  doi: 10.1615/CritRevTherDrugCarrierSyst.2013006475
– volume: 26
  start-page: 2700
  issue: 10
  year: 2018
  ident: 10.1016/j.jconrel.2022.02.011_bb0015
  article-title: Therapeutic peptides: Historical perspectives, current development trends, and future directions
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2017.06.052
– volume: 116
  start-page: 54669
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0650
  article-title: Manufacture and Drug Delivery Applications of Silk Nanoparticles
  publication-title: J. Vis. Exp.
– volume: 15
  issue: 7
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0905
  article-title: Curved microneedle array-based sEMG electrode for robust long-term measurements and high selectivity
  publication-title: Sensors.
  doi: 10.3390/s150716265
– volume: 33
  start-page: 9
  issue: 1
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0020
  article-title: Peptide-Based Therapeutics for Oncology
  publication-title: Pharmaceut Med.
– volume: 10
  start-page: 4033
  issue: 9
  year: 2009
  ident: 10.1016/j.jconrel.2022.02.011_bb0465
  article-title: Degradability of polymers for implantable biomedical devices
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms10094033
– volume: 135
  start-page: 416
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0715
  article-title: A tubular gelatin scaffold capable of the time-dependent controlled release of epidermal growth factor and mitomycin C
  publication-title: Colloids Surf. B: Biointerfaces
  doi: 10.1016/j.colsurfb.2015.06.049
– start-page: 9
  year: 1989
  ident: 10.1016/j.jconrel.2022.02.011_bb0515
  article-title: Diffusion-Controlled Release
– volume: 10
  start-page: 1032
  issue: 5
  year: 2009
  ident: 10.1016/j.jconrel.2022.02.011_bb0675
  article-title: Stabilization of Enzymes in Silk Films
  publication-title: Biomacromolecules.
  doi: 10.1021/bm800956n
– volume: 71
  start-page: 145
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0685
  article-title: In vivo bioresponses to silk proteins
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2015.08.039
– volume: 21
  start-page: 1102
  issue: 11
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0240
  article-title: Recent advances in protein and Peptide drug delivery: a special emphasis on polymeric nanoparticles
  publication-title: Protein Pept. Lett.
  doi: 10.2174/0929866521666140807114240
– volume: 23
  start-page: 404
  issue: 4
  year: 2007
  ident: 10.1016/j.jconrel.2022.02.011_bb0570
  article-title: Poly (ethylene-co-vinyl acetate) copolymer matrix for delivery of chlorhexidine and acyclovir drugs for use in the oral environment: effect of drug combination, copolymer composition and coating on the drug release rate
  publication-title: Dent. Mater.
  doi: 10.1016/j.dental.2006.02.011
– volume: 7
  start-page: 438
  issue: 4
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0150
  article-title: Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum
  publication-title: Pharmaceutics.
  doi: 10.3390/pharmaceutics7040438
– volume: 49
  start-page: 1993
  issue: 8
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0370
  article-title: Hydrogels in drug delivery: progress and challenges
  publication-title: Polymer.
  doi: 10.1016/j.polymer.2008.01.027
– volume: 8
  start-page: 4176
  issue: 15
  year: 2020
  ident: 10.1016/j.jconrel.2022.02.011_bb0730
  article-title: Silk degumming time controls horseradish peroxidase-catalyzed hydrogel properties
  publication-title: Biomater. Sci.
  doi: 10.1039/D0BM00512F
– volume: 59
  start-page: 450
  issue: 3
  year: 2002
  ident: 10.1016/j.jconrel.2022.02.011_bb0455
  article-title: Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium
  publication-title: J. Biomed. Mater. Res.
  doi: 10.1002/jbm.1261
– volume: 12
  start-page: 804
  issue: 3
  year: 2011
  ident: 10.1016/j.jconrel.2022.02.011_bb0750
  article-title: Mechanisms of controlled release from silk fibroin films
  publication-title: Biomacromolecules.
  doi: 10.1021/bm101421r
– volume: 11
  start-page: 3168
  issue: 11
  year: 2017
  ident: 10.1016/j.jconrel.2022.02.011_bb0895
  article-title: Core-shell silk hydrogels with spatially tuned conformations as drug-delivery system
  publication-title: J. Tissue Eng. Regen. Med.
  doi: 10.1002/term.2226
– volume: 190
  start-page: 381
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0755
  article-title: Silk-based biomaterials for sustained drug delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2014.05.059
– volume: 26
  start-page: 3385
  issue: 17
  year: 2005
  ident: 10.1016/j.jconrel.2022.02.011_bb0740
  article-title: In vitro degradation of silk fibroin
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2004.09.020
– volume: 53
  start-page: 756
  issue: 9–10
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0640
  article-title: Silk for drug delivery applications: opportunities and challenges
  publication-title: Israel J. Chem.
  doi: 10.1002/ijch.201300083
– volume: 23
  start-page: 5140
  issue: 41
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0890
  article-title: Silk hydrogels as soft substrates for neural tissue engineering
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.201300435
– volume: 40
  start-page: 536
  issue: 3
  year: 2006
  ident: 10.1016/j.jconrel.2022.02.011_bb0435
  article-title: Protein modification caused by a high dose of gamma irradiation in cryo-sterilized plasma: Protective effects of ascorbate
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2005.09.012
– volume: 21
  start-page: 2615
  issue: 24
  year: 2000
  ident: 10.1016/j.jconrel.2022.02.011_bb0540
  article-title: Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review
  publication-title: Biomaterials.
  doi: 10.1016/S0142-9612(00)00129-0
– volume: 62
  start-page: 1497
  issue: 15
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0635
  article-title: Silk-based delivery systems of bioactive molecules
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2010.03.009
– volume: 15
  start-page: 861
  issue: 6
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0680
  article-title: The effect of sterilization on silk fibroin biomaterial properties
  publication-title: Macromol. Biosci.
  doi: 10.1002/mabi.201500013
– volume: 9
  issue: 4
  year: 2017
  ident: 10.1016/j.jconrel.2022.02.011_bb0120
  article-title: Cilia and mucociliary clearance
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a028241
– volume: 70
  start-page: 269
  issue: 3
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0060
  article-title: Protein and Peptide drug delivery: oral approaches
  publication-title: Indian J. Pharm. Sci.
  doi: 10.4103/0250-474X.42967
– volume: 17
  start-page: 93
  issue: 2
  year: 1996
  ident: 10.1016/j.jconrel.2022.02.011_bb0535
  article-title: Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers
  publication-title: Biomaterials.
  doi: 10.1016/0142-9612(96)85754-1
– volume: 190
  start-page: 381
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0630
  article-title: Silk-based biomaterials for sustained drug delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2014.05.059
– volume: 27
  start-page: 2854
  issue: 14
  year: 2006
  ident: 10.1016/j.jconrel.2022.02.011_bb0485
  article-title: The influence of architecture on degradation and tissue ingrowth into three-dimensional poly(lactic-co-glycolic acid) scaffolds in vitro and in vivo
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2005.12.015
– volume: 107
  start-page: 176
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0280
  article-title: PLA micro- and nano-particles
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2016.05.020
– volume: 71
  start-page: 145
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0495
  article-title: In vivo bioresponses to silk proteins
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2015.08.039
– volume: 56
  start-page: 219
  issue: 1
  year: 1998
  ident: 10.1016/j.jconrel.2022.02.011_bb0420
  article-title: Gamma irradiation effects on poly(dl-lactictide-co-glycolide) microspheres
  publication-title: J. Control. Release
  doi: 10.1016/S0168-3659(98)00082-0
– volume: 7
  start-page: 56550
  issue: 89
  year: 2017
  ident: 10.1016/j.jconrel.2022.02.011_bb0810
  article-title: Fabrication of aqueous-based dual drug loaded silk fibroin electrospun nanofibers embedded with curcumin-loaded RSF nanospheres for drugs controlled release
  publication-title: RSC Adv.
  doi: 10.1039/C7RA12394A
– volume: 17
  start-page: 1290
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0090
  article-title: Recent advancements in non-invasive formulations for protein drug delivery
  publication-title: Comput Struct Biotechnol J.
  doi: 10.1016/j.csbj.2019.09.004
– volume: 117
  start-page: 360
  issue: 3
  year: 2007
  ident: 10.1016/j.jconrel.2022.02.011_bb0780
  article-title: Silk microspheres for encapsulation and controlled release
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2006.11.021
– volume: 5
  start-page: 337
  issue: 3
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0085
  article-title: Recent developments in protein and peptide parenteral delivery approaches
  publication-title: Ther. Deliv.
  doi: 10.4155/tde.14.5
– volume: 19
  start-page: 73
  issue: 1
  year: 2002
  ident: 10.1016/j.jconrel.2022.02.011_bb0575
  article-title: Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems
  publication-title: Crit. Rev. Ther. Drug Carrier Syst.
  doi: 10.1615/CritRevTherDrugCarrierSyst.v19.i1.20
– year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0585
– volume: 5
  start-page: 7
  issue: 1
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0695
  article-title: Decellularized silk fibroin scaffold primed with adipose mesenchymal stromal cells improves wound healing in diabetic mice
  publication-title: Stem Cell Res Ther
  doi: 10.1186/scrt396
– volume: 16
  start-page: 953
  issue: 9
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0245
  article-title: Biodegradable synthetic polyesters in the technology of controlled dosage forms of antihypertensive drugs – the overview
  publication-title: Expert Opin. Drug Delivery.
  doi: 10.1080/17425247.2019.1651716
– volume: 20
  start-page: 309
  issue: 4
  year: 2021
  ident: 10.1016/j.jconrel.2022.02.011_bb0040
  article-title: Trends in peptide drug discovery
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-020-00135-8
– volume: 3
  start-page: 1900140
  issue: 9
  year: 2020
  ident: 10.1016/j.jconrel.2022.02.011_bb0395
  article-title: Biomedical applications of polymeric microneedles for transdermal therapeutic delivery and diagnosis: current status and future perspectives
  publication-title: Adv.Therapeut.
  doi: 10.1002/adtp.201900140
– volume: 285
  issue: 3
  year: 2003
  ident: 10.1016/j.jconrel.2022.02.011_bb0125
  article-title: Thoughts on the pulmonary blood-gas barrier
  publication-title: Am. J. Phys. Lung Cell. Mol. Phys.
– volume: 3
  start-page: 276
  issue: 2
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0390
  article-title: Fabrication of a novel partially dissolving polymer microneedle patch for transdermal drug delivery
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C4TB01555J
– volume: 11
  start-page: 643
  issue: 3
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0765
  article-title: Generation of monodisperse silk microspheres prepared with microfluidics
  publication-title: Biomacromolecules.
  doi: 10.1021/bm901209u
– volume: 12
  start-page: 1686
  issue: 5
  year: 2011
  ident: 10.1016/j.jconrel.2022.02.011_bb0660
  article-title: Regulation of silk material structure by temperature-controlled water vapor annealing
  publication-title: Biomacromolecules.
  doi: 10.1021/bm200062a
– volume: 29
  start-page: 1054
  issue: 8
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0845
  article-title: Sonication-induced gelation of silk fibroin for cell encapsulation
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2007.11.003
– volume: 22
  start-page: 711
  issue: 6
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0850
  article-title: Electrogelation for Protein Adhesives
  publication-title: Adv. Mater.
  doi: 10.1002/adma.200902643
– volume: 34
  start-page: 516
  issue: 2
  year: 2013
  ident: 10.1016/j.jconrel.2022.02.011_bb0145
  article-title: Airway delivery of peptides and proteins using nanoparticles
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2012.08.070
– volume: 116
  start-page: 179
  issue: 3
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0190
  article-title: Mucus as a Barrier to Drug Delivery – Understanding and Mimicking the Barrier Properties
  publication-title: Basic Clin. Pharmacol. Toxicol.
  doi: 10.1111/bcpt.12342
– volume: 6
  start-page: 755
  issue: 6
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0005
  article-title: Peptides and peptidomimetics as immunomodulators
  publication-title: Immunotherapy.
  doi: 10.2217/imt.14.37
– volume: 28
  start-page: 339
  issue: 4
  year: 2020
  ident: 10.1016/j.jconrel.2022.02.011_bb0030
  article-title: Protein drug delivery: current dosage form profile and formulation strategies
  publication-title: J. Drug Target.
  doi: 10.1080/1061186X.2019.1669043
– volume: 50
  start-page: 27
  issue: 1
  year: 2000
  ident: 10.1016/j.jconrel.2022.02.011_bb0745
  article-title: Hydrogels in pharmaceutical formulations
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/S0939-6411(00)00090-4
– volume: 42
  start-page: 186
  issue: 2
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0550
  article-title: Polyurethane-coated breast implants revisited: a 30-year follow-up
  publication-title: Arch. Plast. Surg.
  doi: 10.5999/aps.2015.42.2.186
– start-page: 209
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0100
  article-title: CHAPTER 9 - Pulmonary Drug Delivery
– volume: 19
  start-page: 102
  issue: 1
  year: 2020
  ident: 10.1016/j.jconrel.2022.02.011_bb0670
  article-title: Thermoplastic moulding of regenerated silk
  publication-title: Nat. Mater.
  doi: 10.1038/s41563-019-0560-8
– volume: 26
  start-page: 1261
  issue: 11
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0160
  article-title: Transdermal drug delivery
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1504
– volume: 7
  start-page: 767
  issue: 6
  year: 2007
  ident: 10.1016/j.jconrel.2022.02.011_bb0345
  article-title: PLA nano- and microparticles for drug delivery: an overview of the methods of preparation
  publication-title: Macromol. Biosci.
  doi: 10.1002/mabi.200700022
– volume: 9
  start-page: 27
  issue: 1
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0510
  article-title: Insights into the swelling process and drug release mechanisms from cross-linked pectin/high amylose starch matrices
  publication-title: Asian J. Pharmac. Sci.
– volume: 24
  start-page: 12
  issue: 1
  year: 2020
  ident: 10.1016/j.jconrel.2022.02.011_bb0270
  article-title: Recent advances in polymeric drug delivery systems
  publication-title: Biomater. Res.
  doi: 10.1186/s40824-020-00190-7
– volume: 107
  start-page: 153
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0480
  article-title: Biocompatibility and safety of PLA and its copolymers
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2016.03.012
– volume: 10
  start-page: 1514
  issue: 4
  year: 2009
  ident: 10.1016/j.jconrel.2022.02.011_bb0605
  article-title: Biodegradation of silk biomaterials
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms10041514
– volume: 8
  start-page: 1800465
  issue: 1
  year: 2019
  ident: 10.1016/j.jconrel.2022.02.011_bb0700
  article-title: The biomedical use of silk: past, present, future
  publication-title: Adv. Healthcare Mater.
  doi: 10.1002/adhm.201800465
– volume: 8
  start-page: 15902
  issue: 1
  year: 2017
  ident: 10.1016/j.jconrel.2022.02.011_bb0770
  article-title: Silk micrococoons for protein stabilisation and molecular encapsulation
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15902
– volume: 88
  start-page: 104
  issue: 1
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0825
  article-title: A novel technology using transscleral ultrasound to deliver protein loaded nanoparticles
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2014.04.011
– volume: 1
  start-page: 109
  issue: 1
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0155
  article-title: Challenges and opportunities in dermal/transdermal delivery
  publication-title: Ther. Deliv.
  doi: 10.4155/tde.10.16
– volume: 20
  start-page: 130
  issue: 2
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0490
  article-title: Effects of biomaterial-induced inflammation on fibrosis and rejection
  publication-title: Semin. Immunol.
  doi: 10.1016/j.smim.2007.11.005
– volume: 17
  start-page: 93
  issue: 2
  year: 1996
  ident: 10.1016/j.jconrel.2022.02.011_bb0415
  article-title: Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/ polyglycolic acid copolymers
  publication-title: Biomaterials.
  doi: 10.1016/0142-9612(96)85754-1
– volume: 12
  start-page: 301
  issue: 2
  year: 2006
  ident: 10.1016/j.jconrel.2022.02.011_bb0530
  article-title: Polyglycolic acid-induced inflammation: role of hydrolysis and resulting complement activation
  publication-title: Tissue Eng.
  doi: 10.1089/ten.2006.12.301
– volume: 8
  start-page: 647
  issue: 8
  year: 2017
  ident: 10.1016/j.jconrel.2022.02.011_bb0110
  article-title: Drug delivery to the lungs: challenges and opportunities
  publication-title: Ther. Deliv.
  doi: 10.4155/tde-2017-0037
– volume: 28
  start-page: 820
  issue: 9-10
  year: 2001
  ident: 10.1016/j.jconrel.2022.02.011_bb0360
  article-title: Lysozyme inactivation under mechanical stirring: effect of physical and molecular interfaces
  publication-title: Enzym. Microb. Technol.
  doi: 10.1016/S0141-0229(01)00340-4
– volume: 116
  start-page: 2602
  issue: 4
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0445
  article-title: Degradable Controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.5b00346
– volume: 32
  start-page: 991
  issue: 8–9
  year: 2007
  ident: 10.1016/j.jconrel.2022.02.011_bb0600
  article-title: Silk as a Biomaterial
  publication-title: Prog. Polym. Sci.
  doi: 10.1016/j.progpolymsci.2007.05.013
– volume: 7
  start-page: 429
  issue: 4
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0565
  article-title: Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems
  publication-title: Expert Opin Drug Deliv.
  doi: 10.1517/17425241003602259
– volume: 24
  start-page: 413
  issue: 4
  year: 2016
  ident: 10.1016/j.jconrel.2022.02.011_bb0055
  article-title: A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives
  publication-title: Saudi Pharmaceut. J.
  doi: 10.1016/j.jsps.2014.06.004
– volume: 31
  start-page: 4583
  issue: 16
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0805
  article-title: Controlling silk fibroin particle features for drug delivery
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2010.02.024
– volume: 160
  start-page: 186
  year: 2020
  ident: 10.1016/j.jconrel.2022.02.011_bb0625
  article-title: Bioengineered elastin- and silk-biomaterials for drug and gene delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2020.10.008
– volume: 10
  start-page: 449
  issue: 4
  year: 1993
  ident: 10.1016/j.jconrel.2022.02.011_bb0430
  article-title: Biodegradable microspheres of poly (DL-lactic acid) containing piroxicam as a model drug for controlled release via the parenteral route
  publication-title: J. Microencapsul.
  doi: 10.3109/02652049309015322
– volume: 1
  start-page: 149
  year: 2010
  ident: 10.1016/j.jconrel.2022.02.011_bb0065
  article-title: Polymers for drug delivery systems
  publication-title: Annu Rev Chem Biomol Eng.
  doi: 10.1146/annurev-chembioeng-073009-100847
– volume: 3
  start-page: 65
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0720
  article-title: The potential of silk and silk-like proteins as natural mucoadhesive biopolymers for controlled drug delivery
  publication-title: Front. Chemi.
– volume: 6
  start-page: 16817
  issue: 19
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0835
  article-title: Method to form a fiber/growth factor dual-gradient along electrospun silk for nerve regeneration
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/am504159j
– volume: 6
  start-page: 51
  issue: 2
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0410
  article-title: Radiation sterilization of new drug delivery systems
  publication-title: Interv Med Appl Sci.
– year: 1991
  ident: 10.1016/j.jconrel.2022.02.011_bb0665
– volume: 190
  start-page: 381
  year: 2014
  ident: 10.1016/j.jconrel.2022.02.011_bb0400
  article-title: Silk-based biomaterials for sustained drug delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2014.05.059
– volume: 2
  start-page: 167
  year: 1985
  ident: 10.1016/j.jconrel.2022.02.011_bb0250
  article-title: Controlled drug release from poly(ortho esters) — A surface eroding polymer
  publication-title: J. Control. Release
  doi: 10.1016/0168-3659(85)90042-2
– volume: 9
  start-page: 1
  issue: 1
  year: 1984
  ident: 10.1016/j.jconrel.2022.02.011_bb0105
  article-title: First-pass elimination. Basic concepts and clinical consequences
  publication-title: Clin. Pharmacokinet.
  doi: 10.2165/00003088-198409010-00001
– volume: 358
  start-page: 50
  issue: 1–2
  year: 2008
  ident: 10.1016/j.jconrel.2022.02.011_bb0580
  article-title: Role of a novel multifunctional excipient poly(ethylene glycol)-block-oligo(vinyl sulfadimethoxine) in controlled release of lysozyme from PLGA microspheres
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2008.02.010
– volume: 8
  start-page: 797
  issue: 6
  year: 2011
  ident: 10.1016/j.jconrel.2022.02.011_bb0735
  article-title: Silk fibroin biomaterials for controlled release drug delivery
  publication-title: Expert Opin Drug Deliv.
  doi: 10.1517/17425247.2011.568936
– volume: 11
  start-page: 1280
  issue: 8
  year: 2018
  ident: 10.1016/j.jconrel.2022.02.011_bb0795
  article-title: Porous silk fibroin microspheres sustainably releasing bioactive basic fibroblast growth factor
  publication-title: Materials.
  doi: 10.3390/ma11081280
– volume: 95
  start-page: 271
  year: 2015
  ident: 10.1016/j.jconrel.2022.02.011_bb0880
  article-title: Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2014.12.029
– volume: 3
  start-page: 5375
  issue: 8
  year: 2020
  ident: 10.1016/j.jconrel.2022.02.011_bb0915
  article-title: Silk fibroin microneedle patches for the sustained release of levonorgestrel
  publication-title: ACS Appl. Bio Mater.
  doi: 10.1021/acsabm.0c00671
SSID ssj0005347
Score 2.5974088
SecondaryResourceType review_article
Snippet Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders,...
SourceID pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 176
SubjectTerms Biomaterials
denaturation
Drug delivery
Drug Delivery Systems
Drug release
drugs
Hydrogels
Peptide/protein drugs
Peptides
Polymers
Silk
therapeutics
Title Challenges in delivering therapeutic peptides and proteins: A silk-based solution
URI https://dx.doi.org/10.1016/j.jconrel.2022.02.011
https://www.ncbi.nlm.nih.gov/pubmed/35157939
https://www.proquest.com/docview/2629057782
https://www.proquest.com/docview/2648840894
https://pubmed.ncbi.nlm.nih.gov/PMC9133086
Volume 345
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYQXHqpCm3plodcqeJEdhPbSRxuqxVoCyqiKkjcLL-iZrsKK7IcuPDbmcljH60oUqVcEo-l2DOe-SzPfCbkq2bM8DSClcYFD0SeikAnwgcQ-3UWyyzxdZHY98tkfCPOb-PbDTLqamEwrbL1_Y1Pr711-2XQzuZgVhSDnwBWJMdTQVYDB_TDQqRo5f2nlTQPLpqS6UQGKL2s4hlM-hPYc957PIFgrKbujKKX4tPf-PPPNMqVuHT2jrxtASUdNv-8TTZ8uUOOrhpG6sdjer0ssKqO6RG9WnJVP74nP0bdZSoVLUrq_BTzNCCc0ZXCLDrD1BcHIrp0tGZ2KMrqhA5pVUx_BxgIHe1s-AO5OTu9Ho2D9paFwMZhOA-QcDAxVkiAMiyWkY6szoXUmbaxhZbc6dyxMGWhty7VWKkLGCRhmhsba0BPH8lmeVf6T4SyFIK_kMZkLkWme82tB_yYG-MMKCLrEdHNrbItBTnehDFVXa7ZRLUqUagSFcITRT3SX3SbNRwcr3WQneLUmjEpiBOvdf3SKVrBQsPTE136u4dKwXgyALeAqP4lA_5QhDITPbLbGMfijzkgR3CGMAnpmtksBJDoe72lLH7VhN9ZxDlsPT___7D2yBt8azI198nm_P7BHwCampvDerkckq3ht4vx5TNBYyDE
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB5V5QAXxJvlaSToqdlNbCdxkDhUhWpLHypiK_Vm_IrIskpXzVZoL_wp_iDjPPYBgkpIlXKKbcme8cx8lmc-A7xWlGqWRmhpjLOA5ykPVMJdgLFfZbHIElcXiR0dJ8NT_vEsPtuAn10tjE-rbH1_49Nrb93-GbTSHEyLYvAZwYpg_laQ1sCBtpmVB27-Hc9t1bv996jkN5TufRjtDoP2aYHAxGE4CzzLXqINFxi_aSwiFRmVc6EyZWKDLblVuaVhSkNnbKp8eSoG3oQqpk2sEs92gH7_Bkd34Z9N6P9YySthvKnRTkTgp7csGxqM-2M85F44f-VBac0VGkV_C4h_At7f8zZXAuHeHbjdIliy0wjpLmy48h5snTQU2PNtMlpWdFXbZIucLMmx5_fh0273ektFipJYN_GJIRg_yUolGJn6XBuLXVRpSU0lUZTVW7JDqmLyLfCR15LOaB7A6bXI_iFsluelewyEpog2uNA6s6mn1lfMOASsudZWoyKyHvBOttK0nOf-6Y2J7JLbxrJVifQqkSF-UdSD_mLYtCH9uGqA6BQn13avxMB01dBXnaIlWra_rlGlO7-sJK4nQzSNEO5ffdAB81BkvAePms2xmDFDqIreF4WQrm2bRQfPLL7eUhZfa4bxLGIMz7pP_n9ZL-HmcHR0KA_3jw-ewi3f0qSJPoPN2cWle45QbqZf1KZD4Mt12-ovmhNb7A
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Challenges+in+delivering+therapeutic+peptides+and+proteins%3A+A+silk-based+solution&rft.jtitle=Journal+of+controlled+release&rft.au=Wu%2C+Junqi&rft.au=Sahoo%2C+Jugal+Kishore&rft.au=Li%2C+Yamin&rft.au=Xu%2C+Qiaobing&rft.date=2022-05-01&rft.issn=0168-3659&rft.volume=345&rft.spage=176&rft.epage=189&rft_id=info:doi/10.1016%2Fj.jconrel.2022.02.011&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_jconrel_2022_02_011
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0168-3659&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0168-3659&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0168-3659&client=summon