Specificity and regulation of a synaptic vesicle docking complex

• Published in: Neuron (Cambridge, Mass.) Vol. 13; no. 2; pp. 353 - 361
• Main Authors: Pevsner, Jonathan, Hsu, Shu-Chan, Braun, Janice E.A., Calakos, Nicole, Ting, Anthony E., Bennett, Mark K., Scheller, Richard H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.1994
• Subjects: Amino Acid Sequence; Animals; Exocytosis; Fungal Proteins - physiology; In Vitro Techniques; Macromolecular Substances; Membrane Proteins - physiology; Molecular Sequence Data; Munc18 Proteins; Nerve Tissue Proteins - physiology; Peptides - chemistry; Protein Binding; R-SNARE Proteins; Rats; Recombinant Fusion Proteins; Synaptic Vesicles - physiology; Synaptosomal-Associated Protein 25; Vesicular Transport Proteins

Synaptic vesicles are proposed to dock at the presynaptic plasma membrane through the interaction of two integral membrane proteins of synaptic vesicles, VAMP and synaptotagmin, and two plasma membrane proteins, syntaxin and SNAP-25. We have characterized the binding properties of these proteins and...