Tailored parameter optimization methods for ordinary differential equation models with steady-state constraints - Fiedler, Anna; Raeth, Sebastian; Theis, Fabian J.; Hausser, Angelika; Hasenauer, Jan (BMC systems biology, 2016)
Keywords: Algorithms; Computational Biology - methods; Differential equations; Enzyme Activation - drug effects; Extracellular Signal-Regulated MAP Kinases - metabolism; Feedback, Physiological - drug effects; HeLa Cells; Humans; MAP Kinase Signaling System - drug effects; Mathematical optimization; Mathematical research; Methodology; Models, Biological; Nerve Growth Factor - pharmacology; Parameter estimation; Phosphorylation - drug effects; Reproducibility of Results; S Phase Cell Cycle Checkpoints - drug effects; Sensory Receptor Cells - drug effects; Sensory Receptor Cells - metabolism; Parameter optimization; Differential equation; Steady state; Perturbation experiments