Extranodal Extension Is a Powerful Prognostic Factor in Bladder Cancer Patients with Lymph Node Metastasis

• Published in: European urology Vol. 64; no. 5; pp. 837 - 845
• Main Authors: Fajkovic, Harun, Cha, Eugene K., Jeldres, Claudio, Robinson, Brian D., Rink, Michael, Xylinas, Evanguelos, Chromecki, Thomas F., Breinl, Eckart, Svatek, Robert S., Donner, Gerhard, Tagawa, Scott T., Tilki, Derya, Bastian, Patrick J., Karakiewicz, Pierre I., Volkmer, Bjoern G., Novara, Giacomo, Joual, Abdennabi, Faison, Talia, Sonpavde, Guru, Daneshmand, Siamak, Lotan, Yair, Scherr, Douglas S., Shariat, Shahrokh F.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.11.2013; Elsevier
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Bladder cancer; Chemotherapy, Adjuvant; Chi-Square Distribution; Cystectomy - adverse effects; Cystectomy - mortality; Europe; Extranodal extension; Female; Hematologic and hematopoietic diseases; Humans; Kaplan-Meier Estimate; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymph Node Excision - adverse effects; Lymph Node Excision - mortality; Lymph node metastasis; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic Metastasis; Male; Medical sciences; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Neoplasm Staging; Nephrology. Urinary tract diseases; North America; Prognosis; Proportional Hazards Models; Recurrence; Retrospective Studies; Risk Factors; Survival; Time Factors; Treatment Outcome; Tumors of the urinary system; Urinary Bladder Neoplasms - mortality; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - surgery; Urinary tract. Prostate gland; Urology; Urothelial carcinoma; North America; Europe; Lymph node metastasis; Recurrence; Prognosis; Extranodal extension; Urothelial carcinoma; Bladder cancer; Survival; Human; Nephrology; Relapse; Urinary system disease; Lymph node; Malignant lymphadenopathy; Malignant hemopathy; Urinary tract disease; Malignant tumor; Transitional cell carcinoma; Urology; Extension; Extraganglionar; Bladder disease; Cancer

Lymph node metastasis (LNM) is the most powerful pathologic predictor of disease recurrence after radical cystectomy (RC). However, the outcomes of patients with LNM are highly variable. To assess the prognostic value of extranodal extension (ENE) and other lymph node (LN) parameters. A retrospectiv...