Monocyte-derived dendritic cells from cirrhotic patients retain similar capacity for maturation/activation and antigen presentation as those from healthy subjects

• Published in: Cellular immunology Vol. 295; no. 1; pp. 36 - 45
• Main Authors: Tanoue, Shiroh, Chang, Li-Yuan, Li, Yonghai, Kaplan, David E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.05.2015
• Subjects: Adult; Aged; Antigen Presentation - immunology; Cell Differentiation - immunology; Cell Proliferation; Cells, Cultured; Cirrhosis; Coculture Techniques; Dendritic cell; Dendritic Cells - immunology; Dendritic Cells - metabolism; Enzyme-Linked Immunospot Assay; Flow Cytometry; Glypican-3; Healthy Volunteers; Hepatitis C; Human; Humans; Immunophenotyping; Interferon-gamma - immunology; Interferon-gamma - metabolism; Lipopolysaccharide Receptors - immunology; Lipopolysaccharide Receptors - metabolism; Liver Cirrhosis - immunology; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; M1 macrophage; M2 macrophage; Macrophages - classification; Macrophages - immunology; Male; Middle Aged; Monocyte; Monocytes - immunology; Monocytes - metabolism; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Human; Dendritic cell; Monocyte; MoDC; M1 macrophage; HCC; AFP; CIR; PBMC; Cirrhosis; M2 macrophage; GPC3; HCV; Glypican-3; HD; Hepatitis C

•CD14+ monocytes from cirrhotic patients displayed enhanced M1 and M2 polarization.•MoDC derived from cirrhotic CD14+ monocytes display normal co-stimulation markers.•Antigen-presentation capacity of MoDC from cirrhotic and healthy donors were similar. Few studies have investigated the impact of liv...