Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19

• Published in: International journal of biological sciences Vol. 16; no. 10; pp. 1724 - 1731
• Main Authors: Yang, Naidi, Shen, Han-Ming
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2020; Ivyspring International Publisher
• Subjects: Animals; Apoptosis; Autophagy; Betacoronavirus - physiology; Cell Line; Chemical compounds; Coronaviridae; Coronavirus; Coronavirus Infections - drug therapy; Coronavirus Infections - virology; Coronaviruses; COVID-19; Disease control; Disease transmission; Endocytosis; Endosomes; Epidemics; Humans; Infections; Middle East respiratory syndrome; Molecular Targeted Therapy; Pandemics; Phagocytosis; Pharmacology; Pneumonia, Viral - drug therapy; Pneumonia, Viral - virology; Proteins; Respiratory diseases; Review; RNA viruses; SARS Virus; Severe acute respiratory syndrome coronavirus 2; Signal transduction; Stem cells; Viral diseases; Viral infections; Virus Internalization; Viruses; Middle East; China; COVID-19; SARS-CoV-2; autophagy; Coronaviruses; endocytic pathway

Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA viruses and some of them are known to cause severe respiratory diseases in human, including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the ongoing coronavirus disease-19 (CO...