Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk

• Published in: Scientific reports Vol. 11; no. 1; p. 13430
• Main Authors: Li, Wenqian, Li, Miao, Anthony, Stephen M., Yu, Yan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 28.06.2021; Nature Publishing Group UK; Nature Portfolio
• Subjects: BASIC BIOLOGICAL SCIENCES; Cytokines; Fc receptors; Immune response; Ligands; Membranes; Pathogens; Phagosomes; Receptor mechanisms; Spatial distribution; TLR2 protein; Toll-like receptors

Abstract Many innate immune receptors function collaboratively to detect and elicit immune responses to pathogens, but the physical mechanisms that govern the interaction and signaling crosstalk between the receptors are unclear. In this study, we report that the signaling crosstalk between Fc gamma...