Non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: A randomized, double-blind, sham-controlled ACT2 study

• Published in: Cephalalgia Vol. 38; no. 5; pp. 959 - 969
• Main Authors: Goadsby, Peter J, de Coo, Ilse F, Silver, Nicholas, Tyagi, Alok, Ahmed, Fayyaz, Gaul, Charly, Jensen, Rigmor H, Diener, Hans-Christoph, Solbach, Kasia, Straube, Andreas, Liebler, Eric, Marin, Juana CA, Ferrari, Michel D
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2018
• Subjects: Acute Disease; Adult; Chronic Disease; Cluster Headache - diagnosis; Cluster Headache - physiopathology; Cluster Headache - therapy; Double-Blind Method; Female; Humans; Male; Middle Aged; Original; Placebos; Prospective Studies; Treatment Outcome; Vagus Nerve Stimulation - methods; Vagus Nerve Stimulation - trends; neuromodulation; Episodic cluster headache; chronic cluster headache; non-invasive vagus nerve stimulation; acute treatment; randomized controlled trial

Background Clinical observations and results from recent studies support the use of non-invasive vagus nerve stimulation (nVNS) for treating cluster headache (CH) attacks. This study compared nVNS with a sham device for acute treatment in patients with episodic or chronic CH (eCH, cCH). Methods Afte...