Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters

• Published in: British journal of nutrition Vol. 101; no. 3; pp. 367 - 375
• Main Authors: Ouwehand, Arthur C., Tiihonen, Kirsti, Saarinen, Markku, Putaala, Heli, Rautonen, Nina
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.2009
• Subjects: administration & dosage; age; Aged; Ammonia; Ammonia - analysis; analysis; Analysis of Variance; Bacteria; Bifidobacterium; Bifidobacterium - physiology; Biological and medical sciences; Biomarkers; Biomarkers - analysis; Cathartics; Cathartics - administration & dosage; chemistry; Colony Count, Microbial; defecation; Diet; dietary supplements; Digestive system; Dinoprostone; Dinoprostone - analysis; elderly; elderly nutrition; Fatty Acids; Fatty Acids - analysis; Feces; Feces - chemistry; Feces - microbiology; Feeding. Feeding behavior; Female; Flow Cytometry; Fundamental and applied biological sciences. Psychology; gastrointestinal motility; Humans; immunity; Immunoglobulin A; Immunoglobulin A - analysis; immunology; intestinal microorganisms; intestinal mucosa; Intestines; Intestines - immunology; Intestines - metabolism; Intestines - microbiology; Lactic Acid; Lactic Acid - analysis; Lactitol; Lactobacillus acidophilus; Leukocyte L1 Antigen Complex; Leukocyte L1 Antigen Complex - analysis; Male; metabolism; Microbiology; Older people; pharmacology; physiology; Prebiotics; Probiotics; Probiotics - pharmacology; short chain fatty acids; spermidine; Spermidine - analysis; Sugar Alcohols; Sugar Alcohols - administration & dosage; Synbiotics; Tumor Necrosis Factor-alpha; Tumor Necrosis Factor-alpha - analysis; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young adults; Probiotics; Lactobacillus acidophilus; Synbiotics; Lactitol; Prebiotics; Human; Probiotic; Digestive system; Gut; Probiotics: Prebiotics: Synbiotics: Lactobacillus acidophilus: Lactitol; Vertebrata; Mammalia; Bacteria; Lactobacillaceae; Elderly

With increasing age, a number of physiological changes take place which are reflected in immune and bowel function. These changes may relate to the commonly assumed age-related changes in intestinal microbiota; most noticeably a reduction in bifidobacteria. The current study aimed at modifying the i...