β-Amyloid deposition in brain is enhanced in mouse models of arterial hypertension

• Published in: Neurobiology of aging Vol. 30; no. 2; pp. 222 - 228
• Main Authors: Gentile, Maria Teresa, Poulet, Roberta, Pardo, Alba Di, Cifelli, Giuseppe, Maffei, Angelo, Vecchione, Carmine, Passarelli, Francesca, Landolfi, Alessandro, Carullo, Pierluigi, Lembo, Giuseppe
• Format: Journal Article
• Language: English
• Published: London Elsevier Inc 01.02.2009; Elsevier
• Subjects: Amyloid beta-Peptides - metabolism; Animals; Biological and medical sciences; Blood-Brain Barrier - metabolism; Blood–brain barrier; Brain; Brain - metabolism; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Development. Senescence. Regeneration. Transplantation; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Humans; Hypertension; Hypertension - metabolism; Hypertension - therapy; Immunotherapy; Internal Medicine; Male; Mice; Mice, Inbred C57BL; Neurology; Tissue Distribution; Treatment Outcome; Vertebrates: nervous system and sense organs; β-Amyloid; Hypertension; β-Amyloid; Brain; Immunotherapy; Blood–brain barrier; Animal model; Senescence; Rodentia; Central nervous system; Blood brain barrier; Encephalon; Vertebrata; Mammalia; Mouse; Blood-brain barrier; β Amyloid protein; Animal

Abstract There are conflicting evidence regarding the association of hypertension with Alzheimer's disease (AD), and so far it is still unexplored whether increased blood pressure levels can be mechanistically related to the pathophysiology of AD. Since the deposition of β-amyloid (Aβ) in brain...