Env-Specific Antibodies in Chronic Infection versus in Vaccination

• Published in: Frontiers in immunology Vol. 8; p. 1057
• Main Authors: Soldemo, Martina, Karlsson Hedestam, Gunilla B.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.09.2017
• Subjects: B cells; HIV-1; HIV-1 Infection; Immunology; neutralizing antibodies; vaccine; HIV-1; neutralizing antibodies; vaccine; B cells; HIV-1 Infection

Antibodies are central in vaccine-mediated protection. For HIV-1, a pathogen that displays extreme antigenic variability, B cell responses against conserved determinants of the envelope glycoproteins (Env) are likely required to achieve broadly protective vaccine-induced responses. To understand ant...