Genome Regulation by Polycomb and Trithorax: 70 Years and Counting

• Published in: Cell Vol. 171; no. 1; pp. 34 - 57
• Main Authors: Schuettengruber, Bernd, Bourbon, Henri-Marc, Di Croce, Luciano, Cavalli, Giacomo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.09.2017; Elsevier
• Subjects: Animals; Biochemistry, Molecular Biology; cancer; cellular memory; chromatin; Chromosomal Proteins, Non-Histone - history; Chromosomal Proteins, Non-Histone - metabolism; development; Embryonic Stem Cells - metabolism; epigenetics; Gene Expression Regulation; Genome; Genomics; History, 20th Century; History, 21st Century; Humans; Life Sciences; Neoplasms - metabolism; nuclear architecture; polycomb; Polycomb-Group Proteins - history; Polycomb-Group Proteins - metabolism; transcription; transgenerational epigenetic inheritance; trithorax; nuclear architecture; transgenerational epigenetic inheritance; development; transcription; cellular memory; polycomb; cancer; chromatin; epigenetics; trithorax

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states. Recently, they have been shown to globally control a plethora o...