Haplotype Analysis and a Novel Allele-Sharing Method Refines a Chromosome 4p Locus Linked to Bipolar Affective Disorder

• Published in: Biological psychiatry (1969) Vol. 61; no. 6; pp. 797 - 805
• Main Authors: Le Hellard, Stephanie, Lee, Andrew J, Underwood, Sarah, Thomson, Pippa A, Morris, Stewart W, Torrance, Helen S, Anderson, Susan M, Adams, Richard R, Navarro, Pau, Christoforou, Andrea, Houlihan, Lorna M, Detera-Wadleigh, Sevilla, Owen, Michael J, Asherson, Philip, Muir, Walter J, Blackwood, Douglas H.R, Wray, Naomi R, Porteous, David J, Evans, Kathryn L
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2007
• Subjects: Allele sharing; Alleles; bipolar affective disorder; Bipolar Disorder - genetics; chromosome 4p; Chromosomes, Human, Pair 4 - genetics; Female; Genetic Linkage; Haplotypes - genetics; Humans; linkage; Lod Score; Male; Models, Genetic; Pedigree; Polymorphism, Single Nucleotide; Population Surveillance; Psychiatry; recurrent unipolar depression; schizophrenia; linkage; schizophrenia; Allele sharing; recurrent unipolar depression; chromosome 4p; bipolar affective disorder

Background Bipolar affective disorder (BPAD) and schizophrenia (SCZ) are common conditions. Their causes are unknown, but they include a substantial genetic component. Previously, we described significant linkage of BPAD to a chromosome 4p locus within a large pedigree (F22). Others subsequently hav...