DNA aptamer raised against receptor for advanced glycation end products suppresses renal tubular damage and improves insulin resistance in diabetic mice

• Published in: Diabetes & vascular disease research Vol. 18; no. 1; p. 1479164121990533
• Main Authors: Sotokawauchi, Ami, Matsui, Takanori, Higashimoto, Yuichiro, Nishino, Yuri, Koga, Yoshinori, Yagi, Minoru, Yamagishi, Sho-ichi
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2021
• Subjects: Original; tubular injury; Aptamer; AGEs; RAGE; diabetic nephropathy

Objective: Interaction of advanced glycation end products (AGEs) with the receptor RAGE plays a role in diabetic nephropathy. However, effects of RAGE-aptamer on tubular damage remain unknown. We examined whether RAGE-aptamer inhibited tubular damage in KKAy/Ta mice, obese type 2 diabetic mice with...