Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease

It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migrat...

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Published in	Immunologic research Vol. 51; no. 1; pp. 26 - 38
Main Authors	Basu, Sreemanti, Dittel, Bonnie N.
Format	Journal Article
Language	English
Published	New York Humana Press Inc 01.10.2011 Springer Nature B.V
Subjects	Allergology Animals Biomedical and Life Sciences Biomedicine Cell Differentiation - immunology Cell Movement - immunology Cellular biology Gene expression Gene Expression Regulation - immunology Humans Immune system Immunity, Cellular Immunology Inflammation - immunology Inflammation - therapy Internal Medicine Medicine/Public Health Proteins Receptor, Cannabinoid, CB2 - immunology Signal transduction Signal Transduction - immunology Autoimmunity Immune suppression GPCR Endocannabinoid Cannabinoid receptor 2 Immune system
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Abstract	It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migration, proliferation, and effector functions. In addition, CB2 has been shown to modulate the function of all immune cell types examined to date. CB2 is a G i -protein-coupled receptor and thus exhibits a complex pharmacology allowing both stimulatory and inhibitory signaling that depends on receptor expression levels, ligand concentration, and cell lineage specificities. Here, we discuss both in vitro and in vivo experimental evidence that CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases.
AbstractList	It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migration, proliferation, and effector functions. In addition, CB2 has been shown to modulate the function of all immune cell types examined to date. CB2 is a Gi-protein-coupled receptor and thus exhibits a complex pharmacology allowing both stimulatory and inhibitory signaling that depends on receptor expression levels, ligand concentration, and cell lineage specificities. Here, we discuss both in vitro and in vivo experimental evidence that CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases. It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migration, proliferation, and effector functions. In addition, CB2 has been shown to modulate the function of all immune cell types examined to date. CB2 is a G i -protein-coupled receptor and thus exhibits a complex pharmacology allowing both stimulatory and inhibitory signaling that depends on receptor expression levels, ligand concentration, and cell lineage specificities. Here, we discuss both in vitro and in vivo experimental evidence that CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases. It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migration, proliferation, and effector functions. In addition, CB2 has been shown to modulate the function of all immune cell types examined to date. CB2 is a G^sub i^-protein-coupled receptor and thus exhibits a complex pharmacology allowing both stimulatory and inhibitory signaling that depends on receptor expression levels, ligand concentration, and cell lineage specificities. Here, we discuss both in vitro and in vivo experimental evidence that CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases.[PUBLICATION ABSTRACT] It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migration, proliferation, and effector functions. In addition, CB2 has been shown to modulate the function of all immune cell types examined to date. CB2 is a G(i)-protein-coupled receptor and thus exhibits a complex pharmacology allowing both stimulatory and inhibitory signaling that depends on receptor expression levels, ligand concentration, and cell lineage specificities. Here, we discuss both in vitro and in vivo experimental evidence that CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases.
Author	Dittel, Bonnie N. Basu, Sreemanti
Author_xml	– sequence: 1 givenname: Sreemanti surname: Basu fullname: Basu, Sreemanti organization: Blood Research Institute, Blood Center of Wisconsin, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin – sequence: 2 givenname: Bonnie N. surname: Dittel fullname: Dittel, Bonnie N. email: bonnie.dittel@bcw.edu organization: Blood Research Institute, Blood Center of Wisconsin, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin
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Publisher	Humana Press Inc Springer Nature B.V
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Snippet	It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due...
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SubjectTerms	Allergology Animals Biomedical and Life Sciences Biomedicine Cell Differentiation - immunology Cell Movement - immunology Cellular biology Gene expression Gene Expression Regulation - immunology Humans Immune system Immunity, Cellular Immunology Inflammation - immunology Inflammation - therapy Internal Medicine Medicine/Public Health Proteins Receptor, Cannabinoid, CB2 - immunology Signal transduction Signal Transduction - immunology
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Title	Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease
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