Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface between these microorganisms an...

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Published in	Cell host & microbe Vol. 23; no. 6; pp. 716 - 724
Main Authors	Agus, Allison, Planchais, Julien, Sokol, Harry
Format	Journal Article
Language	English
Published	United States Elsevier Inc 13.06.2018
Subjects	AhR autism Autistic Disorder - metabolism Autistic Disorder - microbiology cerative colitis Colitis - metabolism Communicable Diseases - metabolism Crohn disease Crohn Disease - metabolism Gastrointestinal Microbiome - physiology Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Gastrointestinal Tract - physiology gut microbiota Humans IBD Indoles - metabolism Inflammatory Bowel Diseases - metabolism kynurenine Kynurenine - metabolism Life Sciences Metabolic Syndrome - metabolism Metabolic Syndrome - microbiology Obesity - metabolism serotonin Serotonin - metabolism Short Bowel Syndrome - metabolism Short Bowel Syndrome - microbiology Tryptophan - metabolism Crohn disease serotonin tryptophan metabolism AhR kynurenine IBD gut microbiota autism cerative colitis
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Abstract	The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface between these microorganisms and the host is the essential aromatic amino acid tryptophan (Trp). In the gut, the three major Trp metabolism pathways leading to serotonin (5-hydroxytryptamine), kynurenine (Kyn), and indole derivatives are under the direct or indirect control of the microbiota. In this review, we gather the most recent advances concerning the central role of Trp metabolism in microbiota-host crosstalk in health and disease. Deciphering the complex equilibrium between these pathways will facilitate a better understanding of the pathogenesis of human diseases and open therapeutic opportunities. Many metabolites are involved in host-microbiota interactions. Agus et al. review recent advances concerning the central role of tryptophan metabolism in microbiota-host crosstalk in health and disease. This review examines the direct effect of the gut microbiota in producing tryptophan-derived bioactive molecules and its indirect control of host tryptophan metabolism.
AbstractList	The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface between these microorganisms and the host is the essential aromatic amino acid tryptophan (Trp). In the gut, the three major Trp metabolism pathways leading to serotonin (5-hydroxytryptamine), kynurenine (Kyn), and indole derivatives are under the direct or indirect control of the microbiota. In this review, we gather the most recent advances concerning the central role of Trp metabolism in microbiota-host crosstalk in health and disease. Deciphering the complex equilibrium between these pathways will facilitate a better understanding of the pathogenesis of human diseases and open therapeutic opportunities. Many metabolites are involved in host-microbiota interactions. Agus et al. review recent advances concerning the central role of tryptophan metabolism in microbiota-host crosstalk in health and disease. This review examines the direct effect of the gut microbiota in producing tryptophan-derived bioactive molecules and its indirect control of host tryptophan metabolism. The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface between these microorganisms and the host is the essential aromatic amino acid tryptophan (Trp). In the gut, the three major Trp metabolism pathways leading to serotonin (5-hydroxytryptamine), kynurenine (Kyn), and indole derivatives are under the direct or indirect control of the microbiota. In this review, we gather the most recent advances concerning the central role of Trp metabolism in microbiota-host crosstalk in health and disease. Deciphering the complex equilibrium between these pathways will facilitate a better understanding of the pathogenesis of human diseases and open therapeutic opportunities. The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface between these microorganisms and the host is the essential aromatic amino acid tryptophan (Trp). In the gut, the three major Trp metabolism pathways leading to serotonin (5-hydroxytryptamine), kynurenine (Kyn), and indole derivatives are under the direct or indirect control of the microbiota. In this review, we gather the most recent advances concerning the central role of Trp metabolism in microbiota-host crosstalk in health and disease. Deciphering the complex equilibrium between these pathways will facilitate a better understanding of the pathogenesis of human diseases and open therapeutic opportunities.The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or derived from the transformation of environmental or host molecules. Among the array of metabolites at the interface between these microorganisms and the host is the essential aromatic amino acid tryptophan (Trp). In the gut, the three major Trp metabolism pathways leading to serotonin (5-hydroxytryptamine), kynurenine (Kyn), and indole derivatives are under the direct or indirect control of the microbiota. In this review, we gather the most recent advances concerning the central role of Trp metabolism in microbiota-host crosstalk in health and disease. Deciphering the complex equilibrium between these pathways will facilitate a better understanding of the pathogenesis of human diseases and open therapeutic opportunities.
Author	Agus, Allison Sokol, Harry Planchais, Julien
Author_xml	– sequence: 1 givenname: Allison surname: Agus fullname: Agus, Allison organization: INRA, UMR1319 Micalis & AgroParisTech, Jouy en Josas, France – sequence: 2 givenname: Julien surname: Planchais fullname: Planchais, Julien organization: INRA, UMR1319 Micalis & AgroParisTech, Jouy en Josas, France – sequence: 3 givenname: Harry surname: Sokol fullname: Sokol, Harry email: harry.sokol@aphp.fr organization: INRA, UMR1319 Micalis & AgroParisTech, Jouy en Josas, France
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29902437$$D View this record in MEDLINE/PubMed https://hal.sorbonne-universite.fr/hal-01821219$$DView record in HAL
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Snippet	The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or...
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SubjectTerms	AhR autism Autistic Disorder - metabolism Autistic Disorder - microbiology cerative colitis Colitis - metabolism Communicable Diseases - metabolism Crohn disease Crohn Disease - metabolism Gastrointestinal Microbiome - physiology Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Gastrointestinal Tract - physiology gut microbiota Humans IBD Indoles - metabolism Inflammatory Bowel Diseases - metabolism kynurenine Kynurenine - metabolism Life Sciences Metabolic Syndrome - metabolism Metabolic Syndrome - microbiology Obesity - metabolism serotonin Serotonin - metabolism Short Bowel Syndrome - metabolism Short Bowel Syndrome - microbiology Tryptophan - metabolism
Title	Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
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