Clinical evaluation of targeted arterial perfusion of verapamil and chemotherapeutic drugs in interventional therapy of advanced lung cancer

• Published in: Cancer chemotherapy and pharmacology Vol. 72; no. 4; pp. 889 - 896
• Main Authors: Huang, Jin, Zhang, Tengyue, Ma, Kelong, Fan, Pingsheng, Liu, Yabei, Weng, Chengtao, Fan, Gaofei, Duan, Qiaohong, Zhu, Xianhai
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2013; Springer; Springer Nature B.V
• Subjects: Adult; Aged; Antineoplastic agents; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Calcium Channel Blockers - administration & dosage; Calcium Channel Blockers - pharmacology; Cancer Research; Drug Resistance, Multiple - drug effects; Drug Resistance, Neoplasm - drug effects; Female; Humans; Karnofsky Performance Status; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasm Staging; Oncology; Original; Original Article; Perfusion - methods; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pneumology; Remission Induction - methods; Treatment Outcome; Tumors; Tumors of the respiratory system and mediastinum; Verapamil - administration & dosage; Verapamil - pharmacology; Arterial perfusion; Verapamil; Advanced lung cancer; Multidrug resistance; Antineoplastic agent; Targeting; Lung cancer; Calcium antagonist; Pharmacotherapy; Bronchopulmonary; Target; Blood vessel; Multiple resistance; Aralkylamine; Bronchus disease; Advanced stage; Lung disease; Evaluation; Treatment resistance; Respiratory disease; Malignant tumor; Artery; Treatment; Perfusion; Circulatory system; Cancer
• ISSN: 0344-5704; 1432-0843; 1432-0843
• DOI: 10.1007/s00280-013-2271-1

Purpose To assess the clinical efficacy of targeted arterial perfusion of verapamil and chemotherapeutic agents in the interventional therapy of lung cancer. Methods Forty patients with advanced lung cancer underwent treatment with targeted arterial perfusion of verapamil and chemotherapeutic agents using Seldinger technique. Interventional therapy was performed once a month, and each subject received interventional treatment for 2 or more cycles. The therapeutic efficacy was evaluated 2 months post-treatment. Results Out of 40 patients with advanced lung cancer, 5 cases achieved complete remission (CR) and 29 cases achieved partial remission (PR), with a total effectiveness (CR + PR) rate of 85 %. Besides, 32 cases achieved significantly alleviated clinical symptoms, and 29 cases had decreased clinical tumor stage. All subjects had stable karnofsky performance status score and body weight. Among the 40 patients, 13 cases had leucopenia, 10 cases had gastrointestinal reactions, 3 cases presented with elevated alanine aminotransferase/aspartate aminotransferase ratio, and 3 cases had fever. However, all these side effects relieved quickly. No elevation of BUN/Cr ratio and allergic reactions was observed. No significant changes in cardiac function and electrocardiogram were noticed after the treatment. Conclusions Targeted arterial perfusion of verapamil and chemotherapeutic drugs can improve the clinical symptoms of patients with advanced lung cancer and increase the efficacy of chemotherapeutic agents, thereby providing an opportunity for radiotherapy or surgical treatment for advanced lung cancer.