Retinoic Acid Receptor β Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms

• Published in: The Journal of neuroscience Vol. 35; no. 43; pp. 14467 - 14475
• Main Authors: Rataj-Baniowska, Monika, Niewiadomska-Cimicka, Anna, Paschaki, Marie, Szyszka-Niagolov, Monika, Carramolino, Laura, Torres, Miguel, Dollé, Pascal, Krężel, Wojciech
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 28.10.2015
• Subjects: Animals; Antimetabolites - pharmacology; Bromodeoxyuridine - pharmacology; Corpus Striatum - cytology; Corpus Striatum - embryology; Corpus Striatum - physiology; Female; Fibroblast Growth Factor 3 - metabolism; Fibroblast Growth Factors - physiology; Glutamate Decarboxylase - metabolism; Homeodomain Proteins - physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins - physiology; Neurogenesis - genetics; Neurogenesis - physiology; Neurons - physiology; Pregnancy; Primary Cell Culture; Receptors, Dopamine D1 - metabolism; Receptors, Retinoic Acid - physiology; Substantia Nigra - cytology; Substantia Nigra - embryology; Substantia Nigra - physiology; neurogenesis; MEIS1; retinoic acid receptors; dopamine receptors; FGF; striatum

The mammalian striatum controls sensorimotor and psychoaffective functions through coordinated activities of its two striatonigral and striatopallidal output pathways. Here we show that retinoic acid receptor β (RARβ) controls development of a subpopulation of GABAergic, Gad65-positive striatonigral...