Molecular mechanism of insulin resistance and obesity

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 228; no. 10; p. 1111
• Main Authors: Kadowaki, Takashi, Hara, Kazuo, Yamauchi, Toshimasa, Terauchi, Yasuo, Tobe, Kazuyuki, Nagai, Ryozo
• Format: Journal Article
• Language: English
• Published: England 01.11.2003
• Subjects: Adipocytes - cytology; Adipocytes - physiology; Animals; Diabetes Mellitus, Type 2 - physiopathology; Dietary Fats - pharmacology; Humans; Insulin Resistance - physiology; Mice; Mice, Knockout; Obesity - etiology; Obesity - physiopathology; Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors; Receptors, Cytoplasmic and Nuclear - physiology; Transcription Factors - antagonists & inhibitors; Transcription Factors - physiology

Obesity and insulin resistance have been recognized as leading causes of major health issues. We have endeavored to depict the molecular mechanism of insulin resistance, focusing on the function of adipocyte. We have investigated a role of PPARgamma on the pathogenesis of Type II diabetes. Heterozyg...