Evidence for a Difference in Nitric Oxide Biosynthesis Between Healthy Women and Men

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 32; no. 4; pp. 730 - 734
• Main Authors: Forte, Pablo, Kneale, Barry J., Milne, Eric, Chowienczyk, Phil J., Johnston, Atholl, Benjamin, Nigel, Ritter, James M.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.10.1998; Hagerstown, MD Lippincott
• Subjects: Adult; Arginine - administration & dosage; Arginine - metabolism; Biological and medical sciences; Blood Pressure; Blood vessels and receptors; Body Mass Index; Female; Fundamental and applied biological sciences. Psychology; Humans; Injections, Intravenous; Male; Muscle, Smooth, Vascular - metabolism; Nitrates - urine; Nitric Oxide - biosynthesis; Sex Characteristics; Vertebrates: cardiovascular system; Human; Nitric oxide; Blood vessel; Sex; Female; Male; Biosynthesis; Circulatory system; Comparative study; Endothelium

There is indirect evidence for a gender difference in nitric oxide (NO) synthesis from vascular endothelium. The aim of the present study was to determine NO production more directly in healthy women and men by the measurement of N nitrate excreted in urine after the intravenous administration of L-...