Anti‐tumor effects of suberoylanilide hydroxamic acid on Epstein–Barr virus‐associated T cell and natural killer cell lymphoma

• Published in: Cancer science Vol. 105; no. 6; pp. 713 - 722
• Main Authors: Siddiquey, Mohammed N.A., Nakagawa, Hikaru, Iwata, Seiko, Kanazawa, Tetsuhiro, Suzuki, Michio, Imadome, Ken‐Ichi, Fujiwara, Shigeyoshi, Goshima, Fumi, Murata, Takayuki, Kimura, Hiroshi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.06.2014; BlackWell Publishing Ltd
• Subjects: Acids; Animals; Antineoplastic Agents - therapeutic use; Apoptosis; Apoptosis - drug effects; Cancer; Cell cycle; Cell Cycle Checkpoints - drug effects; Cell Line, Tumor; Disease Progression; Epstein-Barr virus; Epstein-Barr Virus Infections - drug therapy; Extranodal NK‐T‐cell lymphoma; Female; Flow cytometry; Gene expression; Herpesvirus 4, Human; Histone deacetylase; histone deacetylase inhibitor; Histone Deacetylase Inhibitors - therapeutic use; human herpesvirus 4; Humans; Hydroxamic acid; Hydroxamic Acids - therapeutic use; Immunodeficiency; Infections; Interleukin Receptor Common gamma Subunit - genetics; Jurkat Cells; Killer Cells, Natural - virology; Leukemia; Lymphocytes; Lymphocytes B; Lymphocytes T; Lymphoma; Lymphoma, T-Cell - drug therapy; Lymphoma, T-Cell - virology; Metastases; Metastasis; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Natural killer cells; Neoplasm Metastasis; Neoplasm Transplantation; Original; SCID mice; T-Lymphocytes - virology; Transplantation, Heterologous; Tumor cells; Xenograft Model Antitumor Assays; Xenografts; United States > US; Japan; human herpesvirus 4; hydroxamic acid; Extranodal NK-T-cell lymphoma; SCID mice; histone deacetylase inhibitor

The ubiquitous Epstein–Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells and is associated with various lymphoid malignancies. Recent studies have reported that histone deacetylase (HDAC) inhibitors exert anticancer effects against various tumor cells. In the p...