Anti‐tumor effects of suberoylanilide hydroxamic acid on Epstein–Barr virus‐associated T cell and natural killer cell lymphoma

The ubiquitous Epstein–Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells and is associated with various lymphoid malignancies. Recent studies have reported that histone deacetylase (HDAC) inhibitors exert anticancer effects against various tumor cells. In the p...

Full description

Saved in:
Bibliographic Details
Published inCancer science Vol. 105; no. 6; pp. 713 - 722
Main Authors Siddiquey, Mohammed N.A., Nakagawa, Hikaru, Iwata, Seiko, Kanazawa, Tetsuhiro, Suzuki, Michio, Imadome, Ken‐Ichi, Fujiwara, Shigeyoshi, Goshima, Fumi, Murata, Takayuki, Kimura, Hiroshi
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.06.2014
BlackWell Publishing Ltd
Subjects
Acids
Animals
Antineoplastic Agents - therapeutic use
Apoptosis
Apoptosis - drug effects
Cancer
Cell cycle
Cell Cycle Checkpoints - drug effects
Cell Line, Tumor
Disease Progression
Epstein-Barr virus
Epstein-Barr Virus Infections - drug therapy
Extranodal NK‐T‐cell lymphoma
Female
Flow cytometry
Gene expression
Herpesvirus 4, Human
Histone deacetylase
histone deacetylase inhibitor
Histone Deacetylase Inhibitors - therapeutic use
human herpesvirus 4
Humans
Hydroxamic acid
Hydroxamic Acids - therapeutic use
Immunodeficiency
Infections
Interleukin Receptor Common gamma Subunit - genetics
Jurkat Cells
Killer Cells, Natural - virology
Leukemia
Lymphocytes
Lymphocytes B
Lymphocytes T
Lymphoma
Lymphoma, T-Cell - drug therapy
Lymphoma, T-Cell - virology
Metastases
Metastasis
Mice
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Natural killer cells
Neoplasm Metastasis
Neoplasm Transplantation
Original
SCID mice
T-Lymphocytes - virology
Transplantation, Heterologous
Tumor cells
Xenograft Model Antitumor Assays
Xenografts
United States > US
Japan
human herpesvirus 4
hydroxamic acid
Extranodal NK-T-cell lymphoma
SCID mice
histone deacetylase inhibitor
Online AccessGet full text

Cover

Abstract The ubiquitous Epstein–Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells and is associated with various lymphoid malignancies. Recent studies have reported that histone deacetylase (HDAC) inhibitors exert anticancer effects against various tumor cells. In the present study, we have evaluated both the in vitro and in vivo effects of suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor, on EBV‐positive and EBV‐negative T and NK lymphoma cells. Several EBV‐positive and EBV‐negative T and NK cell lines were treated with various concentrations of SAHA. SAHA suppressed the proliferation of T and NK cell lines, although no significant difference was observed between EBV‐positive and EBV‐negative cell lines. SAHA induced apoptosis and/or cell cycle arrest in several T and NK cell lines. In addition, SAHA increased the expression of EBV‐lytic genes and decreased the expression of EBV‐latent genes. Next, EBV‐positive NK cell lymphoma cells were subcutaneously inoculated into severely immunodeficient NOD/Shi‐scid/IL‐2Rγnull mice, and then SAHA was administered intraperitoneally. SAHA inhibited tumor progression and metastasis in the murine xenograft model. SAHA displayed a marked suppressive effect against EBV‐associated T and NK cell lymphomas through either induction of apoptosis or cell cycle arrest, and may represent an alternative treatment option. SAHA inhibits tumor growth and metastasis of EBV‐positive NK cell lymphoma. EBER‐positive cells were detected by in situ hybridization in organ tissues of SAHA‐treated or control mice.
AbstractList The ubiquitous Epstein–Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells and is associated with various lymphoid malignancies. Recent studies have reported that histone deacetylase (HDAC) inhibitors exert anticancer effects against various tumor cells. In the present study, we have evaluated both the in vitro and in vivo effects of suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor, on EBV-positive and EBV-negative T and NK lymphoma cells. Several EBV-positive and EBV-negative T and NK cell lines were treated with various concentrations of SAHA. SAHA suppressed the proliferation of T and NK cell lines, although no significant difference was observed between EBV-positive and EBV-negative cell lines. SAHA induced apoptosis and/or cell cycle arrest in several T and NK cell lines. In addition, SAHA increased the expression of EBV-lytic genes and decreased the expression of EBV-latent genes. Next, EBV-positive NK cell lymphoma cells were subcutaneously inoculated into severely immunodeficient NOD/Shi-scid/IL-2Rγnull mice, and then SAHA was administered intraperitoneally. SAHA inhibited tumor progression and metastasis in the murine xenograft model. SAHA displayed a marked suppressive effect against EBV-associated T and NK cell lymphomas through either induction of apoptosis or cell cycle arrest, and may represent an alternative treatment option.
The ubiquitous Epstein-Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells and is associated with various lymphoid malignancies. Recent studies have reported that histone deacetylase (HDAC) inhibitors exert anticancer effects against various tumor cells. In the present study, we have evaluated both the in vitro and in vivo effects of suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor, on EBV-positive and EBV-negative T and NK lymphoma cells. Several EBV-positive and EBV-negative T and NK cell lines were treated with various concentrations of SAHA. SAHA suppressed the proliferation of T and NK cell lines, although no significant difference was observed between EBV-positive and EBV-negative cell lines. SAHA induced apoptosis and/or cell cycle arrest in several T and NK cell lines. In addition, SAHA increased the expression of EBV-lytic genes and decreased the expression of EBV-latent genes. Next, EBV-positive NK cell lymphoma cells were subcutaneously inoculated into severely immunodeficient NOD/Shi-scid/IL-2Rγnull mice, and then SAHA was administered intraperitoneally. SAHA inhibited tumor progression and metastasis in the murine xenograft model. SAHA displayed a marked suppressive effect against EBV-associated T and NK cell lymphomas through either induction of apoptosis or cell cycle arrest, and may represent an alternative treatment option.
The ubiquitous Epstein-Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells and is associated with various lymphoid malignancies. Recent studies have reported that histone deacetylase (HDAC) inhibitors exert anticancer effects against various tumor cells. In the present study, we have evaluated both the in vitro and in vivo effects of suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor, on EBV-positive and EBV-negative T and NK lymphoma cells. Several EBV-positive and EBV-negative T and NK cell lines were treated with various concentrations of SAHA. SAHA suppressed the proliferation of T and NK cell lines, although no significant difference was observed between EBV-positive and EBV-negative cell lines. SAHA induced apoptosis and/or cell cycle arrest in several T and NK cell lines. In addition, SAHA increased the expression of EBV-lytic genes and decreased the expression of EBV-latent genes. Next, EBV-positive NK cell lymphoma cells were subcutaneously inoculated into severely immunodeficient NOD/Shi-scid/IL-2R gamma null mice, and then SAHA was administered intraperitoneally. SAHA inhibited tumor progression and metastasis in the murine xenograft model. SAHA displayed a marked suppressive effect against EBV-associated T and NK cell lymphomas through either induction of apoptosis or cell cycle arrest, and may represent an alternative treatment option. SAHA inhibits tumor growth and metastasis of EBV-positive NK cell lymphoma. EBER-positive cells were detected by in situ hybridization in organ tissues of SAHA-treated or control mice.
The ubiquitous Epstein–Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells and is associated with various lymphoid malignancies. Recent studies have reported that histone deacetylase (HDAC) inhibitors exert anticancer effects against various tumor cells. In the present study, we have evaluated both the in vitro and in vivo effects of suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor, on EBV‐positive and EBV‐negative T and NK lymphoma cells. Several EBV‐positive and EBV‐negative T and NK cell lines were treated with various concentrations of SAHA. SAHA suppressed the proliferation of T and NK cell lines, although no significant difference was observed between EBV‐positive and EBV‐negative cell lines. SAHA induced apoptosis and/or cell cycle arrest in several T and NK cell lines. In addition, SAHA increased the expression of EBV‐lytic genes and decreased the expression of EBV‐latent genes. Next, EBV‐positive NK cell lymphoma cells were subcutaneously inoculated into severely immunodeficient NOD/Shi‐scid/IL‐2Rγnull mice, and then SAHA was administered intraperitoneally. SAHA inhibited tumor progression and metastasis in the murine xenograft model. SAHA displayed a marked suppressive effect against EBV‐associated T and NK cell lymphomas through either induction of apoptosis or cell cycle arrest, and may represent an alternative treatment option. SAHA inhibits tumor growth and metastasis of EBV‐positive NK cell lymphoma. EBER‐positive cells were detected by in situ hybridization in organ tissues of SAHA‐treated or control mice.
Author Suzuki, Michio
Imadome, Ken‐Ichi
Goshima, Fumi
Nakagawa, Hikaru
Siddiquey, Mohammed N.A.
Iwata, Seiko
Kanazawa, Tetsuhiro
Fujiwara, Shigeyoshi
Kimura, Hiroshi
Murata, Takayuki
Author_xml – sequence: 1
  givenname: Mohammed N.A.
  surname: Siddiquey
  fullname: Siddiquey, Mohammed N.A.
  organization: Nagoya University Graduate School of Medicine
– sequence: 2
  givenname: Hikaru
  surname: Nakagawa
  fullname: Nakagawa, Hikaru
  organization: Nagoya University Graduate School of Medicine
– sequence: 3
  givenname: Seiko
  surname: Iwata
  fullname: Iwata, Seiko
  organization: Nagoya University Graduate School of Medicine
– sequence: 4
  givenname: Tetsuhiro
  surname: Kanazawa
  fullname: Kanazawa, Tetsuhiro
  organization: Nagoya University Graduate School of Medicine
– sequence: 5
  givenname: Michio
  surname: Suzuki
  fullname: Suzuki, Michio
  organization: Nagoya University Graduate School of Medicine
– sequence: 6
  givenname: Ken‐Ichi
  surname: Imadome
  fullname: Imadome, Ken‐Ichi
  organization: National Research Institute for Child Health and Development
– sequence: 7
  givenname: Shigeyoshi
  surname: Fujiwara
  fullname: Fujiwara, Shigeyoshi
  organization: National Research Institute for Child Health and Development
– sequence: 8
  givenname: Fumi
  surname: Goshima
  fullname: Goshima, Fumi
  organization: Nagoya University Graduate School of Medicine
– sequence: 9
  givenname: Takayuki
  surname: Murata
  fullname: Murata, Takayuki
  organization: Nagoya University Graduate School of Medicine
– sequence: 10
  givenname: Hiroshi
  surname: Kimura
  fullname: Kimura, Hiroshi
  organization: Nagoya University Graduate School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24712440$$D View this record in MEDLINE/PubMed
BookMark eNqNks1uFSEUx4mpsR-68AUMiRu7mBYGZgY2Jteb-pE0cWFdkzMM46UycIWZ6uy66AOY-IZ9EmmnNmpiIhsI_PLLOYf_PtrxwRuEnlJyRPM61pCOaMmpeID2KOOyaAipd27PTSEJK3fRfkrnhLCaS_4I7Za8yTwne-hq5Ud7ffl9nIYQsel7o8eEQ4_T1JoYZgfeOtsZvJm7GL7BYDUGbTscPD7ZptFYf3354xXEiC9snFJWQUpBWxhNh8-wNs5h8B32ME4RHP5snTNxuXfzsN2EAR6jhz24ZJ7c7Qfo4-uTs_Xb4vT9m3fr1WmhK0JE0ZaGtbUmBDQH3XFKodKtkUxo1tVE8F5S0TJBdAusBVM3jZZUikZIqJquYgfo5eLdTu1gOm38mEtS22gHiLMKYNWfL95u1KdwoTijWdJkwYs7QQxfJpNGNdh00wp4E6akaJWHSgUR5X-gjFNCpCAZff4Xeh6m6PMkVFlK0khe0TpThwulY0gpmv6-bkrUTQxUjoG6jUFmn_3e6D35698zcLwAX60z879Nar36sCh_AuGiwyo
CitedBy_id crossref_primary_10_1007_s13402_015_0255_3
crossref_primary_10_1038_emm_2014_88
crossref_primary_10_3389_fmicb_2015_00280
crossref_primary_10_3390_v7092858
crossref_primary_10_1016_j_clml_2014_12_014
crossref_primary_10_1016_j_virol_2024_110161
crossref_primary_10_1182_blood_2017_12_791418
crossref_primary_10_3389_fped_2018_00320
crossref_primary_10_1038_s41375_021_01313_2
crossref_primary_10_3390_v13122344
crossref_primary_10_3389_fonc_2022_838817
crossref_primary_10_3389_fped_2018_00417
crossref_primary_10_1016_j_virusres_2019_197667
crossref_primary_10_18632_oncotarget_11175
Cites_doi 10.1038/bjc.2011.156
10.1128/JVI.62.11.4173-4184.1988
10.1158/1078-0432.CCR-04-0166
10.1016/j.molcel.2005.02.029
10.1002/ijc.25873
10.1038/nrmicro958
10.1158/1078-0432.CCR-09-1385
10.1182/blood-2009-07-143545
10.1038/sj.onc.1210620
10.1002/ijc.27439
10.1016/j.canlet.2012.12.022
10.1006/bcmd.2000.0376
10.1074/jbc.M405911200
10.1086/590502
10.1099/vir.0.013482-0
10.1111/j.1349-7006.2011.02127.x
10.1182/blood-2010-09-305979
10.1038/294770a0
10.1128/JVI.69.6.3900-3903.1995
10.1371/journal.ppat.1002326
10.1158/1078-0432.CCR-10-1893
10.1002/ijc.24945
10.1093/annonc/mdp418
10.3892/ijmm.2012.1221
10.1046/j.1365-2249.1999.00836.x
10.1038/sj.bjc.6604764
10.1016/j.jviromet.2007.08.012
10.1371/journal.pone.0063566
10.1056/NEJM200008173430707
10.1038/sj.onc.1210204
10.1182/blood-2004-03-1110
10.4049/jimmunol.174.10.6477
10.1182/blood-2001-12-0207
10.1046/j.1365-2141.2003.04359.x
10.1182/blood-2005-07-2702
10.1038/nrd2133
10.1128/JCM.37.1.132-136.1999
10.1038/sj.leu.2401769
10.1158/1535-7163.MCT-12-0811
10.1002/ajh.2830010206
ContentType Journal Article
Copyright 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.
2014. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. 2014
Copyright_xml – notice: 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.
– notice: 2014. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. 2014
DBID 24P
WIN
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
8FE
8FH
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
7U9
H94
5PM
DOI 10.1111/cas.12418
DatabaseName Wiley-Blackwell Open Access Collection
Wiley Free Archive
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
ProQuest Central
ProQuest Central Student
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
Biological Sciences
Biological Science Database
ProQuest - Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Biological Science Collection
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
Biological Science Database
ProQuest SciTech Collection
ProQuest Central China
ProQuest Central
ProQuest One Academic UKI Edition
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest One Academic
MEDLINE - Academic
AIDS and Cancer Research Abstracts
Virology and AIDS Abstracts
DatabaseTitleList
MEDLINE
Publicly Available Content Database
CrossRef
AIDS and Cancer Research Abstracts
Database_xml – sequence: 1
  dbid: 24P
  name: Wiley-Blackwell Open Access Collection
  url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1349-7006
EndPage 722
ExternalDocumentID 10_1111_cas_12418
24712440
CAS12418
Genre article
Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations United States--US
Japan
GeographicLocations_xml – name: United States--US
– name: Japan
GrantInformation_xml – fundername: Ministry of Education, Culture, Sports, Science and Technology of Japan
  funderid: 25293109
– fundername: Ministry of Health, Labour and Welfare of Japan
  funderid: H24‐Nanchi‐046
GroupedDBID ---
.3N
.55
.GA
.Y3
05W
0R~
10A
1OC
24P
29B
2WC
31~
36B
3O-
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52W
52X
53G
5GY
5HH
5LA
5VS
66C
7.U
702
7PT
8-0
8-1
8-3
8-4
8-5
8FE
8FH
8UM
930
A01
A03
AAHHS
AAZKR
ABCQN
ABEML
ACCFJ
ACSCC
ACXQS
ADBBV
ADKYN
ADZMN
ADZOD
AEEZP
AENEX
AEQDE
AFBPY
AFEBI
AFFNX
AFKRA
AFPKN
AFZJQ
AIWBW
AJBDE
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AOIJS
AVUZU
BAWUL
BBNVY
BCNDV
BENPR
BFHJK
BHPHI
BY8
CAG
CCPQU
COF
CS3
D-6
D-7
D-E
D-F
DIK
DR2
DU5
E3Z
EBS
EJD
EMB
EMOBN
EX3
F00
F01
F04
F5P
FIJ
GODZA
GROUPED_DOAJ
HCIFZ
HF~
HOLLA
HYE
HZI
HZ~
IAO
IHR
IPNFZ
IX1
J0M
K.9
K48
KQ8
LC2
LC3
LH4
LK8
LP6
LP7
LW6
M7P
MK4
N04
N05
N9A
O9-
OIG
OK1
OVD
P2P
P2X
P2Z
P4B
P4D
PIMPY
PROAC
Q11
ROL
RPM
RX1
SJN
SUPJJ
SV3
TEORI
UB1
W8V
WIN
WOW
WQJ
WRC
WXI
X7M
XG1
ZXP
~IA
~WT
CGR
CUY
CVF
ECM
EIF
ITC
NPM
AAYXX
CITATION
ABUWG
AZQEC
DWQXO
GNUQQ
PQEST
PQQKQ
PQUKI
PRINS
7X8
7U9
H94
5PM
ID FETCH-LOGICAL-c5008-b2e3b6c00ac4acd411a5cbe938c3d6084f918b380cba3bae677c9198789a57d53
IEDL.DBID RPM
ISSN 1347-9032
IngestDate Tue Sep 17 20:56:03 EDT 2024
Wed Jul 24 11:15:09 EDT 2024
Thu Jul 25 09:18:28 EDT 2024
Thu Oct 10 22:28:08 EDT 2024
Thu Sep 26 20:55:05 EDT 2024
Sat Sep 28 08:00:52 EDT 2024
Sat Aug 24 01:06:42 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords human herpesvirus 4
hydroxamic acid
Extranodal NK-T-cell lymphoma
SCID mice
histone deacetylase inhibitor
Language English
License Attribution-NonCommercial-NoDerivs
2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c5008-b2e3b6c00ac4acd411a5cbe938c3d6084f918b380cba3bae677c9198789a57d53
Notes Funding information
Ministry of Education, Culture, Sports, Science and Technology of Japan (25293109). Ministry of Health, Labour and Welfare of Japan (H24‐Nanchi‐046).
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317897/
PMID 24712440
PQID 2290794516
PQPubID 4378882
PageCount 10
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4317897
proquest_miscellaneous_1544018082
proquest_miscellaneous_1534100980
proquest_journals_2290794516
crossref_primary_10_1111_cas_12418
pubmed_primary_24712440
wiley_primary_10_1111_cas_12418_CAS12418
PublicationCentury 2000
PublicationDate June 2014
PublicationDateYYYYMMDD 2014-06-01
PublicationDate_xml – month: 06
  year: 2014
  text: June 2014
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: Tokyo
– name: Oxford, UK
PublicationTitle Cancer science
PublicationTitleAlternate Cancer Sci
PublicationYear 2014
Publisher John Wiley & Sons, Inc
BlackWell Publishing Ltd
Publisher_xml – name: John Wiley & Sons, Inc
– name: BlackWell Publishing Ltd
References 2010; 16
2004; 104
2005; 174
2011; 117
2010; 126
2006; 5
1976; 1
2001; 27
2008; 99
2008; 147
2004; 2
2012; 103
2011; 17
2013; 8
2009; 114
2011; 7
2004; 10
2011; 104
2010; 21
1981; 294
2012; 131
2011; 129
2004; 279
2000; 14
1995; 69
2013; 12
2002; 100
1999; 37
2013; 31
2013; 333
1988; 62
2000; 343
2013
1996; 24
2010; 91
2006; 107
2008; 198
1999; 115
2005; 18
2003; 121
2007; 26
10803526 - Leukemia. 2000 May;14(5):922-30
19850638 - Ann Oncol. 2010 May;21(5):1032-40
6275274 - Nature. 1981 Dec 24;294(5843):770-1
18985034 - Br J Cancer. 2008 Dec 2;99(11):1816-22
10944566 - N Engl J Med. 2000 Aug 17;343(7):481-92
15498777 - J Biol Chem. 2004 Dec 24;279(52):54817-25
19793909 - J Gen Virol. 2010 Jan;91(Pt 1):42-50
18627269 - J Infect Dis. 2008 Sep 1;198(5):673-82
16234359 - Blood. 2006 Feb 1;107(3):862-9
22028658 - PLoS Pathog. 2011 Oct;7(10):e1002326
23348693 - Cancer Lett. 2013 Jun 1;333(1):47-55
23658841 - PLoS One. 2013;8(5):e63566
16955068 - Nat Rev Drug Discov. 2006 Sep;5(9):769-84
17694093 - Oncogene. 2007 Aug 13;26(37):5541-52
1087116 - Am J Hematol. 1976;1(2):219-23
21170988 - Int J Cancer. 2011 Nov 1;129(9):2263-73
9854077 - J Clin Microbiol. 1999 Jan;37(1):132-6
11358386 - Blood Cells Mol Dis. 2001 Jan-Feb;27(1):260-4
15569981 - Clin Cancer Res. 2004 Nov 15;10(22):7511-9
21467545 - Blood. 2011 May 26;117(21):5663-73
21559012 - Br J Cancer. 2011 Jun 7;104(12):1828-35
15263900 - Nat Rev Microbiol. 2004 Aug;2(8):656-68
15226177 - Blood. 2004 Nov 1;104(9):2635-42
19724053 - Blood. 2009 Nov 5;114(19):4002-8
15808506 - Mol Cell. 2005 Apr 1;18(1):25-36
15879151 - J Immunol. 2005 May 15;174(10):6477-89
23292124 - Int J Mol Med. 2013 Feb;31(2):339-46
10193407 - Clin Exp Immunol. 1999 Mar;115(3):385-92
21278245 - Clin Cancer Res. 2011 Mar 15;17(6):1582-90
7745743 - J Virol. 1995 Jun;69(6):3900-3
17322921 - Oncogene. 2007 Feb 26;26(9):1351-6
22261816 - Int J Cancer. 2012 Oct 15;131(8):1930-40
12384415 - Blood. 2002 Nov 1;100(9):3175-82
2845129 - J Virol. 1988 Nov;62(11):4173-84
22017376 - Cancer Sci. 2012 Feb;103(2):375-81
17870188 - J Virol Methods. 2008 Jan;147(1):26-36
20028765 - Clin Cancer Res. 2010 Jan 1;16(1):141-53
12780797 - Br J Haematol. 2003 Jun;121(5):805-14
23475956 - Mol Cancer Ther. 2013 May;12(5):747-58
19816947 - Int J Cancer. 2010 May 15;126(10):2479-89
8599969 - Exp Hematol. 1996 Feb;24(3):406-15
e_1_2_7_6_1
e_1_2_7_5_1
e_1_2_7_4_1
e_1_2_7_3_1
e_1_2_7_9_1
e_1_2_7_8_1
e_1_2_7_7_1
e_1_2_7_19_1
e_1_2_7_18_1
e_1_2_7_17_1
e_1_2_7_16_1
e_1_2_7_40_1
e_1_2_7_2_1
e_1_2_7_15_1
e_1_2_7_41_1
e_1_2_7_14_1
e_1_2_7_42_1
e_1_2_7_13_1
e_1_2_7_43_1
e_1_2_7_12_1
e_1_2_7_11_1
e_1_2_7_10_1
Robertson MJ (e_1_2_7_28_1) 1996; 24
e_1_2_7_26_1
e_1_2_7_27_1
e_1_2_7_29_1
e_1_2_7_30_1
e_1_2_7_25_1
e_1_2_7_31_1
Longnecker RM (e_1_2_7_38_1) 2013
e_1_2_7_24_1
e_1_2_7_32_1
e_1_2_7_23_1
e_1_2_7_33_1
e_1_2_7_22_1
e_1_2_7_34_1
e_1_2_7_21_1
e_1_2_7_35_1
e_1_2_7_20_1
e_1_2_7_36_1
e_1_2_7_37_1
e_1_2_7_39_1
References_xml – volume: 99
  start-page: 1816
  year: 2008
  end-page: 22
  article-title: Epstein‐Barr virus renders the infected natural killer cell line, NKL resistant to doxorubicin‐induced apoptosis
  publication-title: Br J Cancer
– volume: 117
  start-page: 5663
  year: 2011
  end-page: 73
  article-title: A novel animal model of Epstein‐Barr virus‐associated hemophagocytic lymphohistiocytosis in humanized mice
  publication-title: Blood
– volume: 26
  start-page: 1351
  year: 2007
  end-page: 6
  article-title: Discovery and development of SAHA as an anticancer agent
  publication-title: Oncogene
– volume: 17
  start-page: 1582
  year: 2011
  end-page: 90
  article-title: Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non‐Hodgkin's lymphomas
  publication-title: Clin Cancer Res
– volume: 37
  start-page: 132
  year: 1999
  end-page: 6
  article-title: Quantitative analysis of Epstein‐Barr virus load by using a real‐time PCR assay
  publication-title: J Clin Microbiol
– volume: 174
  start-page: 6477
  year: 2005
  end-page: 89
  article-title: Human lymphoid and myeloid cell development in NOD/LtSz‐scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
  publication-title: J Immunol
– volume: 16
  start-page: 141
  year: 2010
  end-page: 53
  article-title: Vorinostat enhances the activity of temsirolimus in renal cell carcinoma through suppression of survivin levels
  publication-title: Clin Cancer Res
– volume: 104
  start-page: 1828
  year: 2011
  end-page: 35
  article-title: A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy‐resistant breast cancer
  publication-title: Br J Cancer
– volume: 121
  start-page: 805
  year: 2003
  end-page: 14
  article-title: Common cytological and cytogenetic features of Epstein‐Barr virus (EBV)‐positive natural killer (NK) cells and cell lines derived from patients with nasal T/NK‐cell lymphomas, chronic active EBV infection and hydroa vacciniforme‐like eruptions
  publication-title: Br J Haematol
– volume: 14
  start-page: 922
  year: 2000
  end-page: 30
  article-title: A novel natural killer cell line (KHYG‐1) from a patient with aggressive natural killer cell leukemia carrying a p53 point mutation
  publication-title: Leukemia
– volume: 114
  start-page: 4002
  year: 2009
  end-page: 8
  article-title: How I treat EBV lymphoproliferation
  publication-title: Blood
– volume: 7
  start-page: e1002326
  year: 2011
  article-title: Novel mouse xenograft models reveal a critical role of CD4+ T cells in the proliferation of EBV‐infected T and NK cells
  publication-title: PLoS Pathog
– volume: 18
  start-page: 25
  year: 2005
  end-page: 36
  article-title: Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein‐Barr nuclear antigen 1 implications for EBV‐mediated immortalization
  publication-title: Mol Cell
– start-page: 1898
  year: 2013
  end-page: 959
– volume: 107
  start-page: 862
  year: 2006
  end-page: 9
  article-title: Epstein‐Barr virus: the impact of scientific advances on clinical practice
  publication-title: Blood
– volume: 115
  start-page: 385
  year: 1999
  end-page: 92
  article-title: Characterization of Epstein‐Barr virus (EBV)‐infected natural killer (NK) cell proliferation in patients with severe mosquito allergy; establishment of an IL‐2‐dependent NK‐like cell line
  publication-title: Clin Exp Immunol
– volume: 1
  start-page: 219
  year: 1976
  end-page: 23
  article-title: Identification of T cell lymphoma tumor antigens on human T cell lines
  publication-title: Am J Hematol
– volume: 103
  start-page: 375
  year: 2012
  end-page: 81
  article-title: Antitumor activities of valproic acid on Epstein‐Barr virus‐associated T and natural killer lymphoma cells
  publication-title: Cancer Sci
– volume: 12
  start-page: 747
  year: 2013
  end-page: 58
  article-title: Bortezomib and SAHA synergistically induce ROS‐driven caspase‐dependent apoptosis of nasopharyngeal carcinoma and block replication of Epstein‐Barr virus
  publication-title: Mol Cancer Ther
– volume: 27
  start-page: 260
  year: 2001
  end-page: 4
  article-title: Histone deacetylase inhibitors: development of suberoylanilide hydroxamic acid (SAHA) for the treatment of cancers
  publication-title: Blood Cells Mol Dis
– volume: 100
  start-page: 3175
  year: 2002
  end-page: 82
  article-title: NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells
  publication-title: Blood
– volume: 198
  start-page: 673
  year: 2008
  end-page: 82
  article-title: A new humanized mouse model of Epstein‐Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell‐mediated and humoral immune responses
  publication-title: J Infect Dis
– volume: 343
  start-page: 481
  year: 2000
  end-page: 92
  article-title: Epstein‐Barr virus infection
  publication-title: N Engl J Med
– volume: 294
  start-page: 770
  year: 1981
  end-page: 1
  article-title: Type C virus particles in a cord T‐cell line derived by co‐cultivating normal human cord leukocytes and human leukaemic T cells
  publication-title: Nature
– volume: 62
  start-page: 4173
  year: 1988
  end-page: 84
  article-title: Epstein‐Barr virus latent infection membrane protein alters the human B‐lymphocyte phenotype: deletion of the amino terminus abolishes activity
  publication-title: J Virol
– volume: 5
  start-page: 769
  year: 2006
  end-page: 84
  article-title: Anticancer activities of histone deacetylase inhibitors
  publication-title: Nat Rev Drug Discov
– volume: 8
  start-page: e63566
  year: 2013
  article-title: Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein‐Barr virus‐positive natural killer cell lymphoma
  publication-title: PLoS ONE
– volume: 69
  start-page: 3900
  year: 1995
  end-page: 3
  article-title: Isolation of Epstein‐Barr virus‐infected clones of the human T‐cell line MT‐2: use of recombinant viruses with a positive selection marker
  publication-title: J Virol
– volume: 147
  start-page: 26
  year: 2008
  end-page: 36
  article-title: One‐step multiplex real‐time PCR assay to analyse the latency patterns of Epstein‐Barr virus infection
  publication-title: J Virol Methods
– volume: 279
  start-page: 54817
  year: 2004
  end-page: 25
  article-title: In vivo dynamics of EBNA1‐oriP interaction during latent and lytic replication of Epstein‐Barr virus
  publication-title: J Biol Chem
– volume: 2
  start-page: 656
  year: 2004
  end-page: 68
  article-title: Oncogenic gamma‐herpesviruses: comparison of viral proteins involved in tumorigenesis
  publication-title: Nat Rev Microbiol
– volume: 333
  start-page: 47
  year: 2013
  end-page: 55
  article-title: Comprehensive gene expression profiles of NK cell neoplasms identify vorinostat as an effective drug candidate
  publication-title: Cancer Lett
– volume: 10
  start-page: 7511
  year: 2004
  end-page: 9
  article-title: The use of real‐time reverse transcription‐PCR for prostate‐specific antigen mRNA to discriminate between blood samples from healthy volunteers and from patients with metastatic prostate cancer
  publication-title: Clin Cancer Res
– volume: 104
  start-page: 2635
  year: 2004
  end-page: 42
  article-title: From the bench to the bedside: ways to improve rituximab efficacy
  publication-title: Blood
– volume: 26
  start-page: 5541
  year: 2007
  end-page: 52
  article-title: Histone deacetylase inhibitors: molecular mechanisms of action
  publication-title: Oncogene
– volume: 31
  start-page: 339
  year: 2013
  end-page: 46
  article-title: Synergistic effects of histone deacetylase inhibitor in combination with mTOR inhibitor in the treatment of prostate carcinoma
  publication-title: Int J Mol Med
– volume: 129
  start-page: 2263
  year: 2011
  end-page: 73
  article-title: Bortezomib induces apoptosis in T lymphoma cells and natural killer lymphoma cells independent of Epstein‐Barr virus infection
  publication-title: Int J Cancer
– volume: 126
  start-page: 2479
  year: 2010
  end-page: 89
  article-title: Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein‐Barr virus‐positive epithelial malignancies and mediates enhanced cell death
  publication-title: Int J Cancer
– volume: 91
  start-page: 42
  year: 2010
  end-page: 50
  article-title: Quantitative analysis of Epstein‐Barr virus (EBV)‐related gene expression in patients with chronic active EBV infection
  publication-title: J Gen Virol
– volume: 21
  start-page: 1032
  year: 2010
  end-page: 40
  article-title: Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type
  publication-title: Ann Oncol
– volume: 131
  start-page: 1930
  year: 2012
  end-page: 40
  article-title: Activation of lytic cycle of Epstein‐Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma
  publication-title: Int J Cancer
– volume: 24
  start-page: 406
  year: 1996
  end-page: 15
  article-title: Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia
  publication-title: Exp Hematol
– ident: e_1_2_7_13_1
  doi: 10.1038/bjc.2011.156
– ident: e_1_2_7_31_1
  doi: 10.1128/JVI.62.11.4173-4184.1988
– ident: e_1_2_7_35_1
  doi: 10.1158/1078-0432.CCR-04-0166
– ident: e_1_2_7_40_1
  doi: 10.1016/j.molcel.2005.02.029
– ident: e_1_2_7_30_1
  doi: 10.1002/ijc.25873
– ident: e_1_2_7_39_1
  doi: 10.1038/nrmicro958
– ident: e_1_2_7_41_1
  doi: 10.1158/1078-0432.CCR-09-1385
– ident: e_1_2_7_6_1
  doi: 10.1182/blood-2009-07-143545
– ident: e_1_2_7_8_1
  doi: 10.1038/sj.onc.1210620
– ident: e_1_2_7_15_1
  doi: 10.1002/ijc.27439
– ident: e_1_2_7_16_1
  doi: 10.1016/j.canlet.2012.12.022
– ident: e_1_2_7_10_1
  doi: 10.1006/bcmd.2000.0376
– ident: e_1_2_7_32_1
  doi: 10.1074/jbc.M405911200
– ident: e_1_2_7_18_1
  doi: 10.1086/590502
– ident: e_1_2_7_33_1
  doi: 10.1099/vir.0.013482-0
– ident: e_1_2_7_9_1
  doi: 10.1111/j.1349-7006.2011.02127.x
– ident: e_1_2_7_20_1
  doi: 10.1182/blood-2010-09-305979
– ident: e_1_2_7_26_1
  doi: 10.1038/294770a0
– ident: e_1_2_7_27_1
  doi: 10.1128/JVI.69.6.3900-3903.1995
– ident: e_1_2_7_21_1
  doi: 10.1371/journal.ppat.1002326
– ident: e_1_2_7_12_1
  doi: 10.1158/1078-0432.CCR-10-1893
– ident: e_1_2_7_14_1
  doi: 10.1002/ijc.24945
– volume: 24
  start-page: 406
  year: 1996
  ident: e_1_2_7_28_1
  article-title: Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia
  publication-title: Exp Hematol
  contributor:
    fullname: Robertson MJ
– ident: e_1_2_7_4_1
  doi: 10.1093/annonc/mdp418
– ident: e_1_2_7_42_1
  doi: 10.3892/ijmm.2012.1221
– ident: e_1_2_7_24_1
  doi: 10.1046/j.1365-2249.1999.00836.x
– ident: e_1_2_7_29_1
  doi: 10.1038/sj.bjc.6604764
– ident: e_1_2_7_34_1
  doi: 10.1016/j.jviromet.2007.08.012
– start-page: 1898
  volume-title: Fields Virology
  year: 2013
  ident: e_1_2_7_38_1
  contributor:
    fullname: Longnecker RM
– ident: e_1_2_7_36_1
  doi: 10.1371/journal.pone.0063566
– ident: e_1_2_7_2_1
  doi: 10.1056/NEJM200008173430707
– ident: e_1_2_7_11_1
  doi: 10.1038/sj.onc.1210204
– ident: e_1_2_7_5_1
  doi: 10.1182/blood-2004-03-1110
– ident: e_1_2_7_19_1
  doi: 10.4049/jimmunol.174.10.6477
– ident: e_1_2_7_17_1
  doi: 10.1182/blood-2001-12-0207
– ident: e_1_2_7_22_1
  doi: 10.1046/j.1365-2141.2003.04359.x
– ident: e_1_2_7_3_1
  doi: 10.1182/blood-2005-07-2702
– ident: e_1_2_7_7_1
  doi: 10.1038/nrd2133
– ident: e_1_2_7_37_1
  doi: 10.1128/JCM.37.1.132-136.1999
– ident: e_1_2_7_25_1
  doi: 10.1038/sj.leu.2401769
– ident: e_1_2_7_43_1
  doi: 10.1158/1535-7163.MCT-12-0811
– ident: e_1_2_7_23_1
  doi: 10.1002/ajh.2830010206
SSID ssj0036494
Score 2.2373066
Snippet The ubiquitous Epstein–Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells and is associated with various lymphoid...
The ubiquitous Epstein-Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells and is associated with various lymphoid...
The ubiquitous Epstein–Barr virus ( EBV ) infects not only B cells but also T cells and natural killer ( NK ) cells and is associated with various lymphoid...
SourceID pubmedcentral
proquest
crossref
pubmed
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 713
SubjectTerms Acids
Animals
Antineoplastic Agents - therapeutic use
Apoptosis
Apoptosis - drug effects
Cancer
Cell cycle
Cell Cycle Checkpoints - drug effects
Cell Line, Tumor
Disease Progression
Epstein-Barr virus
Epstein-Barr Virus Infections - drug therapy
Extranodal NK‐T‐cell lymphoma
Female
Flow cytometry
Gene expression
Herpesvirus 4, Human
Histone deacetylase
histone deacetylase inhibitor
Histone Deacetylase Inhibitors - therapeutic use
human herpesvirus 4
Humans
Hydroxamic acid
Hydroxamic Acids - therapeutic use
Immunodeficiency
Infections
Interleukin Receptor Common gamma Subunit - genetics
Jurkat Cells
Killer Cells, Natural - virology
Leukemia
Lymphocytes
Lymphocytes B
Lymphocytes T
Lymphoma
Lymphoma, T-Cell - drug therapy
Lymphoma, T-Cell - virology
Metastases
Metastasis
Mice
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Natural killer cells
Neoplasm Metastasis
Neoplasm Transplantation
Original
SCID mice
T-Lymphocytes - virology
Transplantation, Heterologous
Tumor cells
Xenograft Model Antitumor Assays
Xenografts
SummonAdditionalLinks – databaseName: AUTh Library subscriptions: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELaglRAXxJuUggziwCUiDydOTmhbbVUhtULQSr1FfkWN2DpLsqnYW_8D_5BfwozjLK0qeotiW4nzjT0PT74h5EOpWcxzpcJIYOjGJDyUqs7BSxGGpTKvM0emc3ScH56yL2fZmQ-49T6tctoT3UatW4Ux8k_ISw6yk8X55-XPEKtG4emqL6Fxn2wnMcNj2u29-fHXb9NenOasHMvaMh6WUZp4biHM5cGSYqDcsNrHdY10y8y8nS153Yp1aujgMXnk7Uc6GwF_Qu4Z-5Q8OPIn5M_I1cyumnA1XLQd9bkatK1pP2BiyHohbLNotKHna921v7AWPRWq0bS1dL7ssfLln6vfe6Lr6GXTDX0oPHpG0xOKQX4qrKaODRTe4of7kXC8v1iDXLQX4jk5PZif7B-GvspCqDLMfZCJAUxUFAnFhALoYpEpacq0UKnOo4LVZVzItIiUFKkUJudclRiqKEqRcZ2lL8iWba15RShH7yYSYKFlKbg1pqxzLZFfP451pnkckPfTl66WI5lGNTkhAEfl4AjI7oRB5ddTX_1DPyDvNs2wEnCGwpp2gNHw0Bj5UaO7-jCGlGVFEpCXI6ybN0lAT4OxA6P5DcA3HZCJ-2aLbc4dIzdaYUXJA_LRicb_J1ftz767i527Z_maPATLjI05abtka9UN5g1YPyv51ov4XxC_BmA
  priority: 102
  providerName: ProQuest
– databaseName: Wiley Online Library - Core collection (SURFmarket)
  dbid: DR2
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Lat0wEBUhi9JN3w-3aVFLF9042JZs2XR1GxJCIV20CWRRMHqZmNzYwY_CzSqLfEChf5gv6Yz8ILehpXRnLMkeSTPSkTQ6Q8i7zPBQJFr7gcStGxsJX-kigVWKtJyppIgdmc7B52T_iH86jo83yIfpLszADzFvuKFluPEaDVyq9oaRY0gwmJxCvOiLRHoIiL7M1FEs4dkQ0JYLPwtYNLIKoRfPXHJ9LroFMG_7Sd7Er24C2rtPvk2iD34np9t9p7b1xW-sjv9Ztwfk3ghM6WLQpIdkw1aPyJ2D8ej9MblaVF15ffmj68_qho5uILQuaNujz8lqKatyWRpLT1YGRMQw91Tq0tC6orvnLQbVvL78-VE2Df1eNn0Ln5KjalhDDymeIFBZGeqoRkGSU3dLcXi_XIHS1WfyCTna2z3c2ffHEA6-jtGxQkUWOlwHgdRcatCLUMZa2YylmpkkSHmRhaliaaCVZEraRAid4T5ImslYmJg9JZtVXdnnhApcOgUS4F_MYM1ksyIxCsn7w9DERoQeeTt1Zn4-MHXk0woH2jN37emRramb89FY2xwp72FYisPEI2_mZDAzrKGsbN1DafhpiOSrwd_ycI58aGnkkWeD5sySRAACAElBabGmU3MGpPleT6nKE0f3jRAvzYRH3juV-XPl8p3FV_fw4t-zviR3AQLywflti2x2TW9fAczq1GtnT78Ao5Uocw
  priority: 102
  providerName: Wiley-Blackwell
Title Anti‐tumor effects of suberoylanilide hydroxamic acid on Epstein–Barr virus‐associated T cell and natural killer cell lymphoma
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcas.12418
https://www.ncbi.nlm.nih.gov/pubmed/24712440
https://www.proquest.com/docview/2290794516
https://search.proquest.com/docview/1534100980
https://search.proquest.com/docview/1544018082
https://pubmed.ncbi.nlm.nih.gov/PMC4317897
Volume 105
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1da9swFL00HYy9jH3PWxe0sYe9uLEsy7If05BSBimha6FvRpZkaprIwYlH89b_0H-4XzJJtsNC2R72Yow_sORzpXuvfHwuwNdURpjFQvgBt0s3KmR-LorYZClcRSSPC-rEdGbn8dlV9P2aXh8A7f-FcaR9kZfHerE81uWN41aulmLU88RG89nEOr0kZaMBDBghfYreTr8kjtK2km3E_DQgYScnZOk7toqY8WfYFukLzaxsXFuw748eBZmPuZJ_xrDOCZ2-gOdd9IjGbStfwoHSr-DprPs-_hrux3pT-ptmWdWoY2qgqkDrxtJCtguuy0UpFbrZyrq6s5XoERelRJVG09Xa1r38df9wwusa_SzrZu3zDjsl0SWyS_yIa4mcFqhpxa37jbA9vtgaq6iW_A1cnU4vJ2d-V2PBF9QyH_JQGUREEHARcWGAw5yKXKUkEUTGQRIVKU5ykgQi5yTnKmZMpHahIkk5ZZKSt3CoK63eA2I2twm4ic8oMUmNSotY5lZdH2NJJcMefOnfdLZqpTSyPgUxyGQOGQ-OegyybjStM6tJb-YNimMPPu9Om3Fge8i1qhpzt3kotuqowb-uMYDjxEQ9HrxrYd21pLcHD9ge4LsLrA73_hljnk6PuzNHD7450_h757LJ-Ifb-fDfD_kIz0zIFrVktSM43NSN-mTCok0-hEEYzYfw5GR6Pr8YusUFu70Ih26A_Abl9RJE
link.rule.ids 230,315,733,786,790,870,891,1382,11589,21416,27955,27956,33777,33778,43838,46085,46327,46509,46751,50847,50956,53825,53827,74657
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVgIuiDcpBQziwCUiDztOTmhbbbVAd4VgK_UWObajRmyTbbJB7K3_gX_IL8GTOEurit6i2FbifGPPw5NvAN4livo8ktL1BIZudMDdTOaR8VKEpmEW5awj05nNo-kx_XzCTmzArbFplcOe2G3UqpIYI_-AvORGdpgffVydu1g1Ck9XbQmN27CDlJvxCHb2J_Ov34a9OIxo0pe1pdxNvDCw3EKYy4MlxYxyw2oflzXSNTPzerbkZSu2U0OHD-C-tR_JuAf8IdzS5SO4M7Mn5I_hYlyuC3fdnlU1sbkapMpJ02JiyGYpymJZKE1ON6qufmEteiJkoUhVksmqwcqXfy5-74u6Jj-Lum1cYdHTiiwIBvmJKBXp2EDNW_zofiTs7y83Ri6qM_EEjg8ni4Opa6ssuJJh7kMWaIOJ9DwhqZAGOl8wmekkjGWoIi-meeLHWRh7MhNhJnTEuUwwVBEngnHFwqcwKqtSPwfC0bvxhLHQWGjcGp3kkcqQX9_3FVPcd-Dt8KXTVU-mkQ5OiIEj7eBwYG_AILXrqUn_oe_Am22zWQk4Q1HqqjWjzUN95Ef1bupDKVKWxYEDz3pYt28SGD1tjB0zml8BfNsBmbivtpTFacfIjVZYnHAH3nei8f_JpQfj793F7s2zfA13p4vZUXr0af7lBdwzVhrt89P2YLSuW_3SWELr7JUV97-gWQlW
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3LbtQwFLWglSo2iDehBQxiwSZqHn4kKzQtMyqPjipope4ix3bUiGkyTWYQs-s_8Id8CfcmztCqorsotpU459q-1z45l5B3qWGhFFr7gcKtGxtJP9eFgChFWRbnouCdmM7hVBycsM-n_NTxn1pHqxzmxG6iNrXGPfJd1CUH2-Gh2C0cLeLo4-TD_MLHDFJ40urSadwlm5IJDoHY5t54evRtmJdjwdI-xS2TfhrEkdMZQl4PpheDhQ4zf1xdnW64nDeZk1c92m5Jmjwg950vSUc9-A_JHVs9IluH7rT8MbkcVYvSXyzP64Y63gatC9oukSSymqmqnJXG0rOVaepfmJeeKl0aWld0PG8xC-afy997qmnoz7JZtr5ySFpDjylu-FNVGdopg8Jb_Oh-Kuzvz1ZgI_W5ekJOJuPj_QPfZVzwNUceRB5ZwEcHgdJMaYAxVFznNo0THRsRJKxIwySPk0DnKs6VFVLqFLctklRxaXj8lGxUdWWfEyox0gkUeGs8hhDHpoUwOWrth6HhRoYeeTt86WzeC2tkQ0ACcGQdHB7ZGTDI3Nhqs3-W4JE362IYFdhDVdl6Ca3hoSFqpQa31WEM5cuSyCPPeljXbxLBmg2OD7SW1wBfV0BV7uslVXnWqXOjR5ak0iPvO9P4f-ey_dH37uLF7b18TbbA0rOvn6Zftsk9cNhYT1XbIRuLZmlfglO0yF85a_8L-K8Nig
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Anti-tumor+effects+of+suberoylanilide+hydroxamic+acid+on+Epstein-Barr+virus-associated+T+cell+and+natural+killer+cell+lymphoma&rft.jtitle=Cancer+science&rft.au=Siddiquey%2C+Mohammed+N+A&rft.au=Nakagawa%2C+Hikaru&rft.au=Iwata%2C+Seiko&rft.au=Kanazawa%2C+Tetsuhiro&rft.date=2014-06-01&rft.eissn=1349-7006&rft.volume=105&rft.issue=6&rft.spage=713&rft_id=info:doi/10.1111%2Fcas.12418&rft_id=info%3Apmid%2F24712440&rft.externalDocID=24712440
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1347-9032&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1347-9032&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1347-9032&client=summon