Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status

• Published in: Blood Vol. 107; no. 7; pp. 2889 - 2894
• Main Authors: Thorsélius, Mia, Kröber, Alexander, Murray, Fiona, Thunberg, Ulf, Tobin, Gerard, Bühler, Andreas, Kienle, Dirk, Albesiano, Emilia, Maffei, Rossana, Dao-Ung, Lan-Phuong, Wiley, James, Vilpo, Juhani, Laurell, Anna, Merup, Mats, Roos, Göran, Karlsson, Karin, Chiorazzi, Nicholas, Marasca, Roberto, Döhner, Hartmut, Stilgenbauer, Stephan, Rosenquist, Richard
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2006
• Subjects: Amino Acid Sequence; Australia; Chromosome Aberrations; Europe; Geography; Humans; Immunoglobulin Fragments - chemistry; Immunoglobulin Fragments - genetics; Immunoglobulin Fragments/chemistry/genetics; Immunoglobulin Heavy Chains - genetics; Immunoglobulin Light Chains - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - immunology; Leukemia, Lymphocytic, Chronic, B-Cell - mortality; Medicin och hälsovetenskap; Molecular Sequence Data; Mutation; Survival Analysis; Treatment Outcome; United States; Australia; United States; Europe; Lymphocytic; Chronic/genetics/immunology/mortality; Leukemia; Research Support; Non-U.S. Gov't

We recently reported that Swedish VH3-21-using chronic lymphocytic leukemia (CLL) patients showed restricted immunoglobulin gene features and poor prognosis despite VH mutation status. To investigate this further, we analyzed the VH and VL gene rearrangements in 90 VH3-21+ patients from Sweden, Germ...