Electrophysiological studies of penticainide (CM 7857), a new antiarrhythmic agent, in mammalian myocardium

• Published in: Journal of cardiovascular pharmacology Vol. 9; no. 5; p. 601
• Main Authors: Gautier, P, Guiraudou, P, Pezziardi, F, Bertrand, J P, Gagnol, J P
• Format: Journal Article
• Language: English
• Published: United States 01.05.1987
• Subjects: Action Potentials - drug effects; Animals; Anti-Arrhythmia Agents - pharmacology; Dogs; Electrophysiology; Female; Guinea Pigs; Heart - drug effects; Heart - physiology; Heart Conduction System - physiology; In Vitro Techniques; Male; Propylamines - pharmacology; Purkinje Fibers - physiology; Pyridines; Rabbits; Refractory Period, Electrophysiological

The intracellular electrophysiologic properties of a new antiarrhythmic substance, penticainide, were studied in isolated rabbit, dog, and guinea pig myocardial preparations superfused or perfused with oxygenated Tyrode's solution. "Therapeutic" concentrations of penticainide (1.5 to...