Quantitative differences in the immunomodulatory effects of Rebif and Avonex in IFN-β 1a treated multiple sclerosis patients - Christophi, George P.; Christophi, Jennifer A.; Gruber, Ross C.; Mihai, Cornelia; Mejico, Luis J.; Massa, Paul T.; Jubelt, Burk (Journal of the neurological sciences, 2011)
Keywords: Adjuvants, Immunologic - administration & dosage; Adult; Autoimmunity interferon; Biological and medical sciences; CNS demyelination; Cytokines; Dosage; Dose-Response Relationship, Drug; Down-Regulation - drug effects; Down-Regulation - immunology; Drug Monitoring - methods; EAE/TMEV; Efficacy; Female; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Humans; Immunologic Factors - administration & dosage; Immunologic Factors - physiology; Inflammatory gene expression; Interferon beta-1a; Interferon-beta - administration & dosage; Interferon-beta - therapeutic use; Male; Medical sciences; Middle Aged; Multiple sclerosis; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Multiple Sclerosis, Relapsing-Remitting - drug therapy; Multiple Sclerosis, Relapsing-Remitting - genetics; Multiple Sclerosis, Relapsing-Remitting - immunology; Neurology; Nuclear factor kappa-B (NF-κB); Peripheral immune cells; Secondary Prevention; Signal transducers and activators of transcription STAT; Signaling; Up-Regulation - drug effects; Up-Regulation - immunology; Inflammatory gene expression; Signaling; Multiple sclerosis; EAE/TMEV; Peripheral immune cells; Cytokines; Signal transducers and activators of transcription STAT; Efficacy; CNS demyelination; Nuclear factor kappa-B (NF-κB); Dosage; Autoimmunity interferon; Autoimmunity; Central nervous system; Signal transducers and activators of; Inflammatory disease; Transducer; Signal transduction; transcription STAT; Demyelination; Human; Nervous system diseases; Cytokine; Gene expression; Treatment; Central nervous system disease; Interferon