Mouse and human FcR effector functions

• Published in: Immunological reviews Vol. 268; no. 1; pp. 25 - 51
• Main Authors: Bruhns, Pierre, Jönsson, Friederike
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2015; Wiley
• Series: Fc receptors
• Subjects: Animals; Animals, Genetically Modified; antibody-mediated disease; antibody-mediated therapy; Fc receptor; FcγR; high-affinity receptor; Humans; Immunoglobulin G - immunology; Immunoglobulin G - metabolism; Immunology; Life Sciences; Mice; Mice, Knockout; mouse models; Mutation; Protein Binding; Receptors, Fc - chemistry; Receptors, Fc - genetics; Receptors, Fc - metabolism; Receptors, IgG - genetics; Receptors, IgG - metabolism; mouse models; antibody-mediated therapy; Fc receptor; FcγR; high-affinity receptor; antibody-mediated disease

Summary Mouse and human FcRs have been a major focus of attention not only of the scientific community, through the cloning and characterization of novel receptors, and of the medical community, through the identification of polymorphisms and linkage to disease but also of the pharmaceutical communi...