Synthesis of cyclophosphamide metabolites by a peroxygenase from Marasmius rotula for toxicological studies on human cancer cells - Steinbrecht, Susanne; Kiebist, Jan; König, Rosalie; Thiessen, Markus; Schmidtke, Kai-Uwe; Kammerer, Sarah; Küpper, Jan-Heiner; Scheibner, Katrin (AMB Express, 2020)
Keywords: Acrolein; Bioactive compounds; Biocatalysis; Biocatalysts; Biocompatibility; Biological activity; Biomedical and Life Sciences; Biotechnology; Cancer; Cell viability; Chemical synthesis; Cyclophosphamide; Cytochrome P450; Cytochromes P450; Cytotoxicity; Drug development; Enzymes; Genotoxicity; Human drug metabolites; Hydrogen peroxide; Hydroxylation; Life Sciences; Liver; Marasmius; Metabolites; Microbial Genetics and Genomics; Microbiology; Mustard; Organic compounds; Original; Original Article; Peroxygenase; Toxicity; Toxicity testing; Tumor cell lines; Human drug metabolites; Cyclophosphamide; Biocatalysis; Peroxygenase; Toxicity