The miRNA Content of Exosomes Released from the Glioma Microenvironment Can Affect Malignant Progression

Low-grade gliomas (LGG) are infiltrative primary brain tumors that in 70% of the cases undergo anaplastic transformation, deeply affecting prognosis. However, the timing of progression is heterogeneous. Recently, the tumor microenvironment (TME) has gained much attention either as prognostic factor...

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Published inBiomedicines Vol. 8; no. 12; p. 564
Main Authors Caponnetto, Federica, Dalla, Emiliano, Mangoni, Damiano, Piazza, Silvano, Radovic, Slobodanka, Ius, Tamara, Skrap, Miran, Di Loreto, Carla, Beltrami, Antonio Paolo, Manini, Ivana, Cesselli, Daniela
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 03.12.2020
MDPI
Subjects
Brain cancer
Brain tumors
Cell cycle
DNA methylation
Exosomes
Fluorides
Gene expression
Genetic transformation
Genotype & phenotype
Glioma cells
low-grade gliomas
Medical prognosis
microRNA
miRNA
Nanoparticles
Phenotypes
Precision medicine
Prognosis
Proteins
Radiation therapy
Stem cells
stratification criteria
tumor microenvironment
United Kingdom > UK
Palo Alto California
United States > US
microRNA
tumor microenvironment
exosomes
stratification criteria
low-grade gliomas
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Abstract Low-grade gliomas (LGG) are infiltrative primary brain tumors that in 70% of the cases undergo anaplastic transformation, deeply affecting prognosis. However, the timing of progression is heterogeneous. Recently, the tumor microenvironment (TME) has gained much attention either as prognostic factor or therapeutic target. Through the release of extracellular vesicles, the TME contributes to tumor progression by transferring bioactive molecules such as microRNA. The aim of the study was to take advantage of glioma-associated stem cells (GASC), an in vitro model of the glioma microenvironment endowed with a prognostic significance, and their released exosomes, to investigate the possible role of exosome miRNAs in favoring the anaplastic transformation of LGG. Therefore, by deep sequencing, we analyzed and compared the miRNA profile of GASC and exosomes obtained from LGG patients characterized by different prognosis. Results showed that exosomes presented a different signature, when compared to their cellular counterpart and that, although sharing several miRNAs, exosomes of patients with a bad prognosis, selectively expressed some miRNAs possibly responsible for the more aggressive phenotype. These findings get insights into the value of TME and exosomes as potential biomarkers for precision medicine approaches aimed at improving LGG prognostic stratification and therapeutic strategies.
AbstractList Low-grade gliomas (LGG) are infiltrative primary brain tumors that in 70% of the cases undergo anaplastic transformation, deeply affecting prognosis. However, the timing of progression is heterogeneous. Recently, the tumor microenvironment (TME) has gained much attention either as prognostic factor or therapeutic target. Through the release of extracellular vesicles, the TME contributes to tumor progression by transferring bioactive molecules such as microRNA. The aim of the study was to take advantage of glioma-associated stem cells (GASC), an in vitro model of the glioma microenvironment endowed with a prognostic significance, and their released exosomes, to investigate the possible role of exosome miRNAs in favoring the anaplastic transformation of LGG. Therefore, by deep sequencing, we analyzed and compared the miRNA profile of GASC and exosomes obtained from LGG patients characterized by different prognosis. Results showed that exosomes presented a different signature, when compared to their cellular counterpart and that, although sharing several miRNAs, exosomes of patients with a bad prognosis, selectively expressed some miRNAs possibly responsible for the more aggressive phenotype. These findings get insights into the value of TME and exosomes as potential biomarkers for precision medicine approaches aimed at improving LGG prognostic stratification and therapeutic strategies.
Low-grade gliomas (LGG) are infiltrative primary brain tumors that in 70% of the cases undergo anaplastic transformation, deeply affecting prognosis. However, the timing of progression is heterogeneous. Recently, the tumor microenvironment (TME) has gained much attention either as prognostic factor or therapeutic target. Through the release of extracellular vesicles, the TME contributes to tumor progression by transferring bioactive molecules such as microRNA. The aim of the study was to take advantage of glioma-associated stem cells (GASC), an in vitro model of the glioma microenvironment endowed with a prognostic significance, and their released exosomes, to investigate the possible role of exosome miRNAs in favoring the anaplastic transformation of LGG. Therefore, by deep sequencing, we analyzed and compared the miRNA profile of GASC and exosomes obtained from LGG patients characterized by different prognosis. Results showed that exosomes presented a different signature, when compared to their cellular counterpart and that, although sharing several miRNAs, exosomes of patients with a bad prognosis, selectively expressed some miRNAs possibly responsible for the more aggressive phenotype. These findings get insights into the value of TME and exosomes as potential biomarkers for precision medicine approaches aimed at improving LGG prognostic stratification and therapeutic strategies.Low-grade gliomas (LGG) are infiltrative primary brain tumors that in 70% of the cases undergo anaplastic transformation, deeply affecting prognosis. However, the timing of progression is heterogeneous. Recently, the tumor microenvironment (TME) has gained much attention either as prognostic factor or therapeutic target. Through the release of extracellular vesicles, the TME contributes to tumor progression by transferring bioactive molecules such as microRNA. The aim of the study was to take advantage of glioma-associated stem cells (GASC), an in vitro model of the glioma microenvironment endowed with a prognostic significance, and their released exosomes, to investigate the possible role of exosome miRNAs in favoring the anaplastic transformation of LGG. Therefore, by deep sequencing, we analyzed and compared the miRNA profile of GASC and exosomes obtained from LGG patients characterized by different prognosis. Results showed that exosomes presented a different signature, when compared to their cellular counterpart and that, although sharing several miRNAs, exosomes of patients with a bad prognosis, selectively expressed some miRNAs possibly responsible for the more aggressive phenotype. These findings get insights into the value of TME and exosomes as potential biomarkers for precision medicine approaches aimed at improving LGG prognostic stratification and therapeutic strategies.
Author Manini, Ivana
Mangoni, Damiano
Skrap, Miran
Piazza, Silvano
Ius, Tamara
Dalla, Emiliano
Radovic, Slobodanka
Beltrami, Antonio Paolo
Di Loreto, Carla
Caponnetto, Federica
Cesselli, Daniela
AuthorAffiliation 2 Central RNA Laboratory, Istituto Italiano di Tecnologia (IIT), 16163 Genova, Italy; damiano.mangoni@iit.it
1 Department of Medicine, University of Udine, 33100 Udine, Italy; emiliano.dalla@uniud.it (E.D.); carla.diloreto@uniud.it (C.D.L.); antonio.beltrami@uniud.it (A.P.B.); daniela.cesselli@uniud.it (D.C.)
4 IGA Technology Services, S.R.L., 33100 Udine, Italy; sradovic@igatechnology.com
3 International Center for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy; piazza@icgeb.org
5 Neurosurgery Unit, Department of Neurosciences, University Hospital of Udine, 33100 Udine, Italy; tamara.ius@asufc.sanita.fvg.it (T.I.); skrap@asufc.sanita.fvg.it (M.S.)
6 Institute of Pathology, University Hospital of Udine, 33100 Udine, Italy
AuthorAffiliation_xml – name: 1 Department of Medicine, University of Udine, 33100 Udine, Italy; emiliano.dalla@uniud.it (E.D.); carla.diloreto@uniud.it (C.D.L.); antonio.beltrami@uniud.it (A.P.B.); daniela.cesselli@uniud.it (D.C.)
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Keywords microRNA
tumor microenvironment
exosomes
stratification criteria
low-grade gliomas
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Snippet Low-grade gliomas (LGG) are infiltrative primary brain tumors that in 70% of the cases undergo anaplastic transformation, deeply affecting prognosis. However,...
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SubjectTerms Brain cancer
Brain tumors
Cell cycle
DNA methylation
Exosomes
Fluorides
Gene expression
Genetic transformation
Genotype & phenotype
Glioma cells
low-grade gliomas
Medical prognosis
microRNA
miRNA
Nanoparticles
Phenotypes
Precision medicine
Prognosis
Proteins
Radiation therapy
Stem cells
stratification criteria
tumor microenvironment
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Title The miRNA Content of Exosomes Released from the Glioma Microenvironment Can Affect Malignant Progression
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Volume 8
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