Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection - Arce, Pablo M.; Goldschmidt, Ruth; Khdour, Omar M.; Madathil, Manikandadas M.; Jaruvangsanti, Jennifer; Dey, Sriloy; Fash, David M.; Armstrong, Jeffrey S.; Hecht, Sidney M. (Bioorganic & medicinal chemistry, 2012)
Keywords: Animals; antagonists & inhibitors; antioxidant activity; Antioxidants; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Biochemistry & Molecular Biology; Biological and medical sciences; Cattle; Cell Survival; Cell Survival - drug effects; chemical synthesis; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Cytoprotection; Cytoprotection - drug effects; Dose-Response Relationship, Drug; drug effects; Drugs; Electron transport chain; enzymology; Humans; Idebenone; Life Sciences & Biomedicine; Lipid Peroxidation; Lipid Peroxidation - drug effects; Lymphocytes; Lymphocytes - drug effects; Lymphocytes - metabolism; Medical sciences; metabolism; Mitochondria; Mitochondria, Heart; Mitochondria, Heart - drug effects; Mitochondria, Heart - enzymology; Mitochondria, Heart - metabolism; Mitochondrial dysfunction; Mitochondrial Membranes; Mitochondrial Membranes - drug effects; Mitochondrial Membranes - metabolism; Molecular Structure; Multienzyme Complexes; Multienzyme Complexes - antagonists & inhibitors; Multienzyme Complexes - metabolism; NADH, NADPH Oxidoreductases; NADH, NADPH Oxidoreductases - antagonists & inhibitors; NADH, NADPH Oxidoreductases - metabolism; Neuroprotection; pharmacology; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; Pyridones; Pyridones - chemical synthesis; Pyridones - chemistry; Pyridones - pharmacology; Reactive Oxygen Species; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Science & Technology; Structure-Activity Relationship; Tumor Cells, Cultured; Electron transport chain; Idebenone; Reactive oxygen species; Mitochondrial dysfunction; OXIDATIVE STRESS; FRIEDREICHS-ATAXIA; REACTIVITY; NEURODEGENERATIVE DISEASES; PERMEABILITY TRANSITION; COMPLEX-I; GLUTATHIONE; DYSFUNCTION; RESPIRATORY COMPLEXES; Oxidative stress; Psychotropic; Quinone; Benzoquinone derivatives; Antioxidant; Respiratory chain; Mitochondria; Cytoprotector; Nootropic agent; Cell respiration