Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies

Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively inte...

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Published inMarine drugs Vol. 22; no. 3; p. 114
Main Authors Dalisay, Doralyn S, Tenebro, Chuckcris P, Sabido, Edna M, Suarez, Angelica Faith L, Paderog, Melissa June V, Reyes-Salarda, Rikka, Saludes, Jonel P
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.02.2024
MDPI
Subjects
Actinobacteria
Algae
Animals
Anthozoa
anticancer
Anticancer properties
Antimitotic agents
Antineoplastic Agents
Antineoplastic drugs
Apoptosis
apoptotic agents
Bioactive compounds
Biological products
Cancer
Cancer therapies
Cell cycle
Cell death
Cells
Chemical properties
Chromatin
Clinical trials
combination therapy
Competition
Condensates
Corals
Cyanobacteria
Cyclin-dependent kinases
Defense mechanisms
DNA repair
Drug resistance
FDA approval
Fungi
Health aspects
Innovations
Kinases
Leukemia
Lymphoma
Macrophages
marine actinobacteria
Marine algae
Marine fauna
Marine invertebrates
marine natural products
Marine organisms
marine sponges
Materials
Mode of action
Molecular modelling
Mollusks
Natural products
Neoplasms
Organisms
Phagocytosis
Physiological aspects
Prospective Studies
Proteins
R&D
Research & development
Review
Shellfish
Philippines
apoptotic agents
marine actinobacteria
marine sponges
mechanism of action
combination therapy
clinical trials
marine natural products
anticancer
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Abstract Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively interact with extrinsic and intrinsic apoptotic pathways using a variety of molecular mechanisms, resulting in cell shrinkage, chromatin condensation, cytoplasmic blebs, apoptotic bodies, and phagocytosis by adjacent parenchymal cells, neoplastic cells, or macrophages. Numerous marine-derived compounds are currently undergoing rigorous examination for their potential application in cancer therapy. This review examines a total of 21 marine-derived compounds, along with their synthetic derivatives, sourced from marine organisms such as sponges, corals, tunicates, mollusks, ascidians, algae, cyanobacteria, fungi, and actinobacteria. These compounds are currently undergoing preclinical and clinical trials to evaluate their potential as apoptosis inducers for the treatment of different types of cancer. This review further examined the compound's properties and mode of action, preclinical investigations, clinical trial studies on single or combination therapy, and the prospective development of marine-derived anticancer therapies.
AbstractList Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively interact with extrinsic and intrinsic apoptotic pathways using a variety of molecular mechanisms, resulting in cell shrinkage, chromatin condensation, cytoplasmic blebs, apoptotic bodies, and phagocytosis by adjacent parenchymal cells, neoplastic cells, or macrophages. Numerous marine-derived compounds are currently undergoing rigorous examination for their potential application in cancer therapy. This review examines a total of 21 marine-derived compounds, along with their synthetic derivatives, sourced from marine organisms such as sponges, corals, tunicates, mollusks, ascidians, algae, cyanobacteria, fungi, and actinobacteria. These compounds are currently undergoing preclinical and clinical trials to evaluate their potential as apoptosis inducers for the treatment of different types of cancer. This review further examined the compound's properties and mode of action, preclinical investigations, clinical trial studies on single or combination therapy, and the prospective development of marine-derived anticancer therapies.
Audience Academic
Author Suarez, Angelica Faith L
Dalisay, Doralyn S
Tenebro, Chuckcris P
Sabido, Edna M
Reyes-Salarda, Rikka
Saludes, Jonel P
Paderog, Melissa June V
AuthorAffiliation 4 Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines; aicasuarez03@gmail.com
2 Department of Biology, University of San Agustin, Iloilo City 5000, Philippines; rikka.salarda@isatu.edu.ph
3 Balik Scientist Program, Department of Science and Technology, Philippine Council for Health Research and Development (DOST-PCHRD), Taguig 1631, Philippines; jsaludes@usa.edu.ph
6 Department of Chemistry, University of San Agustin, Iloilo City 5000, Philippines
1 Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines; ctenebro@usa.edu.ph (C.P.T.); ednasabido@usa.edu.ph (E.M.S.); mpaderog@usa.edu.ph (M.J.V.P.)
5 Department of Pharmacy, University of San Agustin, Iloilo City 5000, Philippines
AuthorAffiliation_xml – name: 6 Department of Chemistry, University of San Agustin, Iloilo City 5000, Philippines
– name: 4 Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines; aicasuarez03@gmail.com
– name: 1 Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines; ctenebro@usa.edu.ph (C.P.T.); ednasabido@usa.edu.ph (E.M.S.); mpaderog@usa.edu.ph (M.J.V.P.)
– name: 2 Department of Biology, University of San Agustin, Iloilo City 5000, Philippines; rikka.salarda@isatu.edu.ph
– name: 3 Balik Scientist Program, Department of Science and Technology, Philippine Council for Health Research and Development (DOST-PCHRD), Taguig 1631, Philippines; jsaludes@usa.edu.ph
– name: 5 Department of Pharmacy, University of San Agustin, Iloilo City 5000, Philippines
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  givenname: Doralyn S
  orcidid: 0000-0003-2850-7797
  surname: Dalisay
  fullname: Dalisay, Doralyn S
  organization: Balik Scientist Program, Department of Science and Technology, Philippine Council for Health Research and Development (DOST-PCHRD), Taguig 1631, Philippines
– sequence: 2
  givenname: Chuckcris P
  surname: Tenebro
  fullname: Tenebro, Chuckcris P
  organization: Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines
– sequence: 3
  givenname: Edna M
  surname: Sabido
  fullname: Sabido, Edna M
  organization: Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines
– sequence: 4
  givenname: Angelica Faith L
  surname: Suarez
  fullname: Suarez, Angelica Faith L
  organization: Center for Natural Drug Discovery and Development (CND3), University of San Agustin, Iloilo City 5000, Philippines
– sequence: 5
  givenname: Melissa June V
  orcidid: 0000-0001-8403-7115
  surname: Paderog
  fullname: Paderog, Melissa June V
  organization: Department of Pharmacy, University of San Agustin, Iloilo City 5000, Philippines
– sequence: 6
  givenname: Rikka
  orcidid: 0000-0001-6370-6156
  surname: Reyes-Salarda
  fullname: Reyes-Salarda, Rikka
  organization: Department of Biology, University of San Agustin, Iloilo City 5000, Philippines
– sequence: 7
  givenname: Jonel P
  orcidid: 0000-0001-9536-5982
  surname: Saludes
  fullname: Saludes, Jonel P
  organization: Department of Chemistry, University of San Agustin, Iloilo City 5000, Philippines
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38535455$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords apoptotic agents
marine actinobacteria
marine sponges
mechanism of action
combination therapy
clinical trials
marine natural products
anticancer
Language English
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Snippet Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated...
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StartPage 114
SubjectTerms Actinobacteria
Algae
Animals
Anthozoa
anticancer
Anticancer properties
Antimitotic agents
Antineoplastic Agents
Antineoplastic drugs
Apoptosis
apoptotic agents
Bioactive compounds
Biological products
Cancer
Cancer therapies
Cell cycle
Cell death
Cells
Chemical properties
Chromatin
Clinical trials
combination therapy
Competition
Condensates
Corals
Cyanobacteria
Cyclin-dependent kinases
Defense mechanisms
DNA repair
Drug resistance
FDA approval
Fungi
Health aspects
Innovations
Kinases
Leukemia
Lymphoma
Macrophages
marine actinobacteria
Marine algae
Marine fauna
Marine invertebrates
marine natural products
Marine organisms
marine sponges
Materials
Mode of action
Molecular modelling
Mollusks
Natural products
Neoplasms
Organisms
Phagocytosis
Physiological aspects
Prospective Studies
Proteins
R&D
Research & development
Review
Shellfish
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Title Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies
URI https://www.ncbi.nlm.nih.gov/pubmed/38535455
https://www.proquest.com/docview/3003335750
https://search.proquest.com/docview/3003440195
https://pubmed.ncbi.nlm.nih.gov/PMC10972102
https://doaj.org/article/ed60fc157157498f9c20d507b6cddf5c
Volume 22
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