Evaluating the Role of Epigenetic Histone Modifications in the Metabolic Memory of Type 1 Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 63; no. 5; pp. 1748 - 1762
• Main Authors: Miao, Feng, Chen, Zhuo, Genuth, Saul, Paterson, Andrew, Zhang, Lingxiao, Wu, Xiwei, Li, Sierra Min, Cleary, Patricia, Riggs, Arthur, Harlan, David M., Lorenzi, Gayle, Kolterman, Orville, Sun, Wanjie, Lachin, John M., Natarajan, Rama
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.2014
• Subjects: Adult; Biological and medical sciences; Blood Glucose - metabolism; Chromatin; Clinical trials; Complications; Diabetes; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - metabolism; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - genetics; Diabetic Retinopathy - metabolism; Disease Progression; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Epidemiology; Epigenesis, Genetic; Epigenetics; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Histones - genetics; Histones - metabolism; Humans; Hypoglycemic Agents - therapeutic use; Male; Medical sciences; Middle Aged; Proteins; Endocrinopathy; Immunopathology; Type 1 diabetes; Memory; Epigenetics; Autoimmune disease; Histone

We assessed whether epigenetic histone posttranslational modifications are associated with the prolonged beneficial effects (metabolic memory) of intensive versus conventional therapy during the Diabetes Control and Complications Trial (DCCT) on the progression of microvascular outcomes in the long-...