Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

• Published in: Cell host & microbe Vol. 30; no. 11; pp. 1540 - 1555.e15
• Main Authors: Saito, Akatsuki, Tamura, Tomokazu, Zahradnik, Jiri, Deguchi, Sayaka, Tabata, Koshiro, Anraku, Yuki, Kimura, Izumi, Ito, Jumpei, Yamasoba, Daichi, Nasser, Hesham, Toyoda, Mako, Nagata, Kayoko, Uriu, Keiya, Kosugi, Yusuke, Fujita, Shigeru, Shofa, Maya, Monira Begum, MST, Shimizu, Ryo, Oda, Yoshitaka, Suzuki, Rigel, Ito, Hayato, Nao, Naganori, Wang, Lei, Tsuda, Masumi, Yoshimatsu, Kumiko, Kuramochi, Jin, Kita, Shunsuke, Sasaki-Tabata, Kaori, Fukuhara, Hideo, Maenaka, Katsumi, Yamamoto, Yuki, Nagamoto, Tetsuharu, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Ueno, Takamasa, Schreiber, Gideon, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Sawa, Hirofumi, Irie, Takashi, Hashiguchi, Takao, Takayama, Kazuo, Matsuno, Keita, Tanaka, Shinya, Ikeda, Terumasa, Fukuhara, Takasuke, Sato, Kei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.11.2022; The Author(s). Published by Elsevier Inc
• Subjects: Antibodies, Neutralizing; Antibodies, Viral; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; antiviral drug resistance; BA.2.75; COVID-19; COVID-19 Serotherapy; Humans; immune resistance; Omicron; pathogenicity; SARS-CoV-2; SARS-CoV-2 - genetics; Spike Glycoprotein, Coronavirus - genetics; transmissibility; COVID-19; pathogenicity; SARS-CoV-2; transmissibility; immune resistance; antiviral drug resistance; Omicron; BA.2.75

The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We de...