A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo

• Published in: American journal of physiology. Renal physiology Vol. 303; no. 4; pp. F593 - F603
• Main Authors: Zhang, Jun, Preda, Dorin V, Vasquez, Kristine O, Morin, Jeff, Delaney, Jeannine, Bao, Bagna, Percival, M David, Xu, Daigen, McKay, Dan, Klimas, Michael, Bednar, Bohumil, Sur, Cyrille, Gao, David Z, Madden, Karen, Yared, Wael, Rajopadhye, Milind, Peterson, Jeffrey D
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.08.2012
• Subjects: Animal Feed - analysis; Animals; Cathepsin D; Cathepsin G; Female; Fluorescence; Fluorescent Dyes - pharmacology; Humans; Innovative Methodology; Kidneys; Mice; Mice, Inbred C57BL; Peptides - pharmacology; Peptidyl-Dipeptidase A - metabolism; Plasma; Rats; Renin - blood; Renin - metabolism; Renin-Angiotensin System - physiology; Rodents; Sensitivity and Specificity; Sodium; Sodium, Dietary; Tissues

The renin-angiotensin system (RAS) is well studied for its regulation of blood pressure and fluid homeostasis, as well as for increased activity associated with a variety of diseases and conditions, including cardiovascular disease, diabetes, and kidney disease. The enzyme renin cleaves angiotensino...