Effect of increases in cardiac contractility on cerebral blood flow in humans

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 313; no. 6; pp. H1155 - H1161
• Main Authors: Ogoh, Shigehiko, Moralez, Gilbert, Washio, Takuro, Sarma, Satyam, Hieda, Michinari, Romero, Steven A., Cramer, Matthew N., Shibasaki, Manabu, Crandall, Craig G.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.12.2017
• Series: Integrative Cardiovascular Physiology and Pathophysiology
• Subjects: Arteries; Blood flow; Blood pressure; Cardiac output; Carotid artery; Drug dosages; External pressure; Heart rate; Risk assessment; Ultrasonic imaging; Veins & arteries; cardiac output; blood pressure; internal carotid artery; dobutamine; external carotid artery

The effect of acute increases in cardiac contractility on cerebral blood flow (CBF) remains unknown. We hypothesized that the external carotid artery (ECA) downstream vasculature modifies the direct influence of acute increases in heart rate and cardiac function on CBF regulation. Twelve healthy sub...