MtuA, a Lipoprotein Receptor Antigen from Streptococcus uberis, Is Responsible for Acquisition of Manganese during Growth in Milk and Is Essential for Infection of the Lactating Bovine Mammary Gland

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Published inInfection and Immunity Vol. 71; no. 9; pp. 4842 - 4849
Main Authors SMITH, Amanda J, WARD, Philip N, FIELD, Terence R, JONES, Catherine L, LINCOLN, Ruth A, LEIGH, James A
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.09.2003
Subjects
Animals
Antigens, Bacterial - genetics
Antigens, Bacterial - metabolism
Bacteriology
Base Sequence
Biological and medical sciences
Cattle
DNA, Bacterial - genetics
Female
Fundamental and applied biological sciences. Psychology
Genes, Bacterial
Lactation
Mammary Glands, Animal - microbiology
Manganese - metabolism
Mastitis, Bovine - etiology
Mastitis, Bovine - microbiology
Microbiology
Milk - microbiology
Miscellaneous
Molecular Pathogenesis
Molecular Sequence Data
Mutagenesis, Insertional
Receptors, Lipoprotein - genetics
Receptors, Lipoprotein - immunology
Receptors, Lipoprotein - metabolism
Streptococcus - genetics
Streptococcus - growth & development
Streptococcus - pathogenicity
Streptococcus - physiology
Virulence - genetics
Bovine
Microbiology
Streptococcus uberis
Lipoprotein
Immunity
Antigen
Streptococcaceae
Vertebrata
Mammalia
Streptococcus A
Bacteria
Micrococcales
Artiodactyla
Mammary gland
Veterinary
Ungulata
Milk
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Abstract Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
AbstractList A mutant strain of Streptococcus uberis (AJS001) that was unable to grow in bovine milk was isolated following random insertional mutagenesis. The level of growth in milk was restored to that of the parental strain (strain 0140J) following addition of MnSO sub(4) but not following addition of other metal ions. The mutant contained a single insertion within mtuA, a homologue of mtsA and psaA, which encode metal-binding proteins in Streptococcus pyogenes and Streptococcus pneumoniae, respectively. Strain AJS001 was unable to infect any of eight quarters on four dairy cows following intramammary challenge with 10 CFU. Bacteria were never recovered directly from milk of these animals but were detected following enrichment in Todd-Hewitt broth in three of eight milk samples obtained within 24 h of challenge. The animals showed no inflammatory response and no signs of mastitis. Three mammary quarters on two different animals simultaneously challenged with 600 CFU of the parental strain, strain 0140J, became colonized, shed high numbers of S. uberis organisms in milk, displayed a marked inflammatory response to infection, and showed overt signs of mastitis. These data indicate that mtuA was required for efficient uptake of Mn super(2+) during growth in bovine milk and infection of the lactating bovine mammary gland.
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue IAI About IAI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy Connect to IAI IAI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0019-9567 Online ISSN: 1098-5522 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to IAI .asm.org, visit: IAI       
A mutant strain of Streptococcus uberis (AJS001) that was unable to grow in bovine milk was isolated following random insertional mutagenesis. The level of growth in milk was restored to that of the parental strain (strain 0140J) following addition of MnSO 4 but not following addition of other metal ions. The mutant contained a single insertion within mtuA , a homologue of mtsA and psaA , which encode metal-binding proteins in Streptococcus pyogenes and Streptococcus pneumoniae , respectively. Strain AJS001 was unable to infect any of eight quarters on four dairy cows following intramammary challenge with 10 5 CFU. Bacteria were never recovered directly from milk of these animals but were detected following enrichment in Todd-Hewitt broth in three of eight milk samples obtained within 24 h of challenge. The animals showed no inflammatory response and no signs of mastitis. Three mammary quarters on two different animals simultaneously challenged with 600 CFU of the parental strain, strain 0140J, became colonized, shed high numbers of S. uberis organisms in milk, displayed a marked inflammatory response to infection, and showed overt signs of mastitis. These data indicate that mtuA was required for efficient uptake of Mn 2+ during growth in bovine milk and infection of the lactating bovine mammary gland.
A mutant strain of Streptococcus uberis (AJS001) that was unable to grow in bovine milk was isolated following random insertional mutagenesis. The level of growth in milk was restored to that of the parental strain (strain 0140J) following addition of MnSO(4) but not following addition of other metal ions. The mutant contained a single insertion within mtuA, a homologue of mtsA and psaA, which encode metal-binding proteins in Streptococcus pyogenes and Streptococcus pneumoniae, respectively. Strain AJS001 was unable to infect any of eight quarters on four dairy cows following intramammary challenge with 10(5) CFU. Bacteria were never recovered directly from milk of these animals but were detected following enrichment in Todd-Hewitt broth in three of eight milk samples obtained within 24 h of challenge. The animals showed no inflammatory response and no signs of mastitis. Three mammary quarters on two different animals simultaneously challenged with 600 CFU of the parental strain, strain 0140J, became colonized, shed high numbers of S. uberis organisms in milk, displayed a marked inflammatory response to infection, and showed overt signs of mastitis. These data indicate that mtuA was required for efficient uptake of Mn(2+) during growth in bovine milk and infection of the lactating bovine mammary gland.
Author Catherine L. Jones
Terence R. Field
James A. Leigh
Amanda J. Smith
Ruth A. Lincoln
Philip N. Ward
AuthorAffiliation Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berks RG20 7NN, United Kingdom
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Issue 9
Keywords Bovine
Microbiology
Streptococcus uberis
Lipoprotein
Immunity
Antigen
Streptococcaceae
Vertebrata
Mammalia
Streptococcus A
Bacteria
Micrococcales
Artiodactyla
Mammary gland
Veterinary
Ungulata
Milk
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Editor: A. D. O'Brien
Corresponding author. Mailing address: Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berks RG 20 7NN, United Kingdom. Phone: 4 1635 577249. Fax: 4 1635 577243. E-mail: james.leigh@bbsrc.ac.uk.
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SSID ssj0014448
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Snippet Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit...
A mutant strain of Streptococcus uberis (AJS001) that was unable to grow in bovine milk was isolated following random insertional mutagenesis. The level of...
A mutant strain of Streptococcus uberis (AJS001) that was unable to grow in bovine milk was isolated following random insertional mutagenesis. The level of...
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StartPage 4842
SubjectTerms Animals
Antigens, Bacterial - genetics
Antigens, Bacterial - metabolism
Bacteriology
Base Sequence
Biological and medical sciences
Cattle
DNA, Bacterial - genetics
Female
Fundamental and applied biological sciences. Psychology
Genes, Bacterial
Lactation
Mammary Glands, Animal - microbiology
Manganese - metabolism
Mastitis, Bovine - etiology
Mastitis, Bovine - microbiology
Microbiology
Milk - microbiology
Miscellaneous
Molecular Pathogenesis
Molecular Sequence Data
Mutagenesis, Insertional
Receptors, Lipoprotein - genetics
Receptors, Lipoprotein - immunology
Receptors, Lipoprotein - metabolism
Streptococcus - genetics
Streptococcus - growth & development
Streptococcus - pathogenicity
Streptococcus - physiology
Virulence - genetics
Title MtuA, a Lipoprotein Receptor Antigen from Streptococcus uberis, Is Responsible for Acquisition of Manganese during Growth in Milk and Is Essential for Infection of the Lactating Bovine Mammary Gland
URI http://iai.asm.org/content/71/9/4842.abstract
https://www.ncbi.nlm.nih.gov/pubmed/12933824
https://search.proquest.com/docview/18813350
https://pubmed.ncbi.nlm.nih.gov/PMC187302
Volume 71
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