Clarification of the Mechanism of Structural Change Induced by Reoxygenation following the Induction of Lipid Peroxidation in Caco-2 Cell Monolayers

• Published in: DRUG METABOLISM AND PHARMACOKINETICS Vol. 17; no. 1; pp. 83 - 91
• Main Authors: Tomita, Mikio, Nagira, Mayuko, Haga, Makoto, Hayashi, Masahiro
• Format: Journal Article
• Language: English; Japanese
• Published: England Elsevier Ltd 2002; Japanese Society for the Study of Xenobiotics
• Subjects: Caco-2 cell monolayers; iron ions; ischemia; lipid peroxidation; P-glycoprotein; reperfusion injury; superoxide anion; TJ opening; P-glycoprotein; Caco-2 cell monolayers; TJ opening; iron ions; reperfusion injury; superoxide anion; lipid peroxidation; ischemia

Recently, we established a system for assessing ischemia/reperfusion injury, specifically the opening of tight junctions (TJ), caused by reoxygenation following the induction of lipid peroxidation by tertiary-butylhydroperoxide (t-BuOOH), using the human intestinal epithelial cell line Caco-2 in ord...