Chronic IL-15 Stimulation and Impaired mTOR Signaling and Metabolism in Natural Killer Cells During Acute Myeloid Leukemia

• Published in: Frontiers in immunology Vol. 12; p. 730970
• Main Authors: Bou-Tayeh, Berna, Laletin, Vladimir, Salem, Nassim, Just-Landi, Sylvaine, Fares, Joanna, Leblanc, Raphael, Balzano, Marielle, Kerdiles, Yann M, Bidaut, Ghislain, Hérault, Olivier, Olive, Daniel, Aurrand-Lions, Michel, Walzer, Thierry, Nunès, Jacques A, Fauriat, Cyril
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 17.12.2021; Frontiers Media S.A
• Subjects: acute myeloid leukemia; Animals; Case-Control Studies; Cells, Cultured; chronic stimulation; Disease Models, Animal; exhaustion; Female; Humans; IL-15/mTOR signaling; Immunology; Interleukin-15 - metabolism; Interleukin-15 - pharmacology; Killer Cells, Natural - immunology; Leukemia, Myeloid, Acute - blood; Leukemia, Myeloid, Acute - immunology; Life Sciences; Male; metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; natural killer cells; Signal Transduction - drug effects; Signal Transduction - genetics; TOR Serine-Threonine Kinases - metabolism; exhaustion; natural killer cells; IL-15/mTOR signaling; metabolism; acute myeloid leukemia; chronic stimulation

Natural Killer (NK) cells are potent anti-leukemic immune effectors. However, they display multiple defects in acute myeloid leukemia (AML) patients leading to reduced anti-tumor potential. Our limited understanding of the mechanisms underlying these defects hampers the development of strategies to...