Identification of a Brainstem Circuit Controlling Feeding

• Published in: Cell Vol. 170; no. 3; pp. 429 - 442.e11
• Main Authors: Nectow, Alexander R., Schneeberger, Marc, Zhang, Hongxing, Field, Bianca C., Renier, Nicolas, Azevedo, Estefania, Patel, Bindiben, Liang, Yupu, Mitra, Siddhartha, Tessier-Lavigne, Marc, Han, Ming-Hu, Friedman, Jeffrey M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.07.2017
• Subjects: agonists; Animals; Appetite Regulation; Body Weight; Brain - physiology; brain stem; dorsal raphe nucleus; Dorsal Raphe Nucleus - cytology; Dorsal Raphe Nucleus - metabolism; Electrophysiology; energy balance; energy homeostasis; Fasting; feeding; food intake; gamma-aminobutyric acid; Hunger; hypothalamus; leptin resistance; locomotion; locomotor activity; Male; Mice; Mice, Inbred C57BL; Mice, Obese; neurons; Neurons - metabolism; obesity; Optogenetics; receptors; transporters; dorsal raphe nucleus; body weight; leptin resistance; feeding; locomotor activity; energy homeostasis; obesity

Hunger, driven by negative energy balance, elicits the search for and consumption of food. While this response is in part mediated by neurons in the hypothalamus, the role of specific cell types in other brain regions is less well defined. Here, we show that neurons in the dorsal raphe nucleus, expr...