The Application of Microsampling Disks in Circular Dichroism Spectroscopy for Peptide and Nucleic Acid Drugs

• Published in: Chemical & pharmaceutical bulletin Vol. 72; no. 7; pp. 658 - 663
• Main Authors: Tsuji, Genichiro, Misawa, Takashi, Demizu, Yosuke
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 11.07.2024; Japan Science and Technology Agency
• Subjects: Circular Dichroism; circular dichroism (CD) spectra; Cost analysis; Dichroism; Drug development; Drugs; Effectiveness; medium-sized drug; microsampling disk; nucleic acid; Nucleic acids; Nucleic Acids - analysis; Nucleic Acids - chemistry; peptide; Peptides; Peptides - analysis; Peptides - chemistry; Product safety; Quality assessment; Quality control; secondary structure; Spectroscopic analysis; Spectroscopy; Spectrum analysis; Structural analysis; Structural integrity; secondary structure; circular dichroism (CD) spectra; microsampling disk; peptide; nucleic acid; medium-sized drug

In recent years, there has been a growing focus on the development of medium-sized drugs based on peptides or nucleic acids owing to their potential therapeutic benefits. As some of these medium-sized drugs exert their therapeutic effects by adopting specific secondary structures, evaluating their c...