Chronic lithium treatment induces novel patterns of pendrin localization and expression

• Published in: American journal of physiology. Renal physiology Vol. 315; no. 2; pp. F313 - F322
• Main Authors: Himmel, Nathaniel J, Wang, Yirong, Rodriguez, Daniel A, Sun, Michael A, Blount, Mitsi A
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2018
• Subjects: Adenosine triphosphatase; Ammonium Compounds - urine; Animals; Aquaporin 4; Aquaporin 4 - metabolism; Cell Plasticity - drug effects; Cell Proliferation - drug effects; Chloride-Bicarbonate Antiporters - genetics; Chloride-Bicarbonate Antiporters - metabolism; Collecting duct; Diet; Drug Administration Schedule; Gene expression; Gene Expression Regulation; H+-transporting ATPase; Homeostasis; Hydrogen-Ion Concentration; Kidney Tubules, Collecting - drug effects; Kidney Tubules, Collecting - metabolism; Kidney Tubules, Collecting - pathology; Kidneys; Lithium; Lithium Carbonate - toxicity; Localization; Male; Osmolar Concentration; Phenotype; Phenotypes; Polyuria - chemically induced; Polyuria - pathology; Polyuria - urine; Rats, Sprague-Dawley; Rodents; Side effects; Signal Transduction; Sulfate Transporters - genetics; Sulfate Transporters - metabolism; Time Factors; Urine; Vacuolar Proton-Translocating ATPases - metabolism; lithium; pendrin; diabetes insipidus; acid-base homeostasis; acidosis

Prolonged lithium treatment is associated with various renal side effects and is known to induce inner medullary collecting duct (IMCD) remodeling. In animals treated with lithium, the fraction of intercalated cells (ICs), which are responsible for acid-base homeostasis, increases compared with rena...