The Trials within Cohorts design faced methodological advantages and disadvantages in the exercise oncology setting

• Published in: Journal of clinical epidemiology Vol. 113; pp. 137 - 146
• Main Authors: Gal, Roxanne, Monninkhof, Evelyn M, van Gils, Carla H, Groenwold, Rolf H.H, van den Bongard, Desirée H.J.G, Peeters, Petra H.M, Verkooijen, Helena M, May, Anne M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2019; Elsevier Limited
• Subjects: Adult; Aged; Aged, 80 and over; Biomedical Research - methods; Breast cancer; Breast Neoplasms - therapy; Clinical trials; cmRCT; Cohort multiple randomized controlled trial; Cohort Studies; Contamination; Design; Epidemiology; Exercise; Exercise Therapy - methods; Female; Humans; Internal Medicine; Intervention; Logistics; Middle Aged; Oncology; Participation; Patient Dropouts - statistics & numerical data; Patient Participation - statistics & numerical data; Patient Selection; Patients; Physical activity; Physical fitness; Pollution control; Pollution prevention; Prospective Studies; Questionnaires; Radiation therapy; Randomization; Randomized Controlled Trials as Topic - statistics & numerical data; Research Design; Studies; Trials within Cohorts; TwiCs; Writing; Trials within Cohorts; TwiCs; Breast cancer; Cohort multiple randomized controlled trial; Physical activity; cmRCT

AbstractObjectivesThe Trials within Cohorts (TwiCs) design is an alternative for pragmatic randomized controlled trials (RCTs) and might overcome disadvantages such as difficult recruitment, dropout after randomization to control, and contamination. We investigated the applicability of the TwiCs des...