Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitis

Progenitor cell activation with subsequent maturation to hepatocytes and cells of the biliary lineage has been demonstrated in a variety of chronic liver diseases but the kinetics and magnitude of the progenitor cell response has not been adequately studied in detail in chronic hepatitis. We underto...

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Published inJournal of hepatology Vol. 41; no. 6; pp. 983 - 991
Main Authors Eleazar, Jennifer A., Memeo, Lorenzo, Jhang, Jeffrey S., Mansukhani, Mahesh M., Chin, Steven, Park, Soo Mi, Lefkowitch, Jay H., Bhagat, Govind
Format Journal Article
LanguageEnglish
Published Oxford Elsevier B.V 01.12.2004
Elsevier
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Bile Ducts - pathology
Biological and medical sciences
Bipotential progenitors
Cell Division
Child
Child, Preschool
Chronic hepatitis
Cytokeratin
DNA - metabolism
Ductular reaction
Female
Gastroenterology. Liver. Pancreas. Abdomen
Grade
Hepatitis B, Chronic - pathology
Hepatitis B, Chronic - physiopathology
Hepatitis C, Chronic - pathology
Hepatitis C, Chronic - physiopathology
Hepatitis, Autoimmune - pathology
Hepatitis, Autoimmune - physiopathology
Hepatocytes - pathology
Humans
Immunohistochemistry
Infant
Keratin-7
Keratins - metabolism
Liver - metabolism
Liver - pathology
Liver - physiopathology
Liver Regeneration
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Ploidy
S Phase
Stage
Stem Cells - pathology
Cytokeratin
Ploidy
Ductular reaction
Chronic hepatitis
Stage
Grade
Bipotential progenitors
Hepatic disease
Hepatitis
Regeneration
Chronic
Hepatocyte
Digestive diseases
Expansion
Progenitor cell
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Abstract Progenitor cell activation with subsequent maturation to hepatocytes and cells of the biliary lineage has been demonstrated in a variety of chronic liver diseases but the kinetics and magnitude of the progenitor cell response has not been adequately studied in detail in chronic hepatitis. We undertook this study to evaluate factors responsible for the progenitor cell/ductular response and further dissect the role of disease grade and stage as determinants of hepatocellular differentiation of bipotential progenitor cells in chronic hepatitis. Cytokeratin 7 (and 19) stained biopsies from patients with chronic hepatitis C ( n=47), hepatitis B ( n=20), and autoimmune hepatitis ( n=20) were studied. Ploidy analysis and proliferation indices were evaluated in a subset of cases. Ductular reactions were present in the majority of cases (97%), appeared early in disease, and correlated with disease activity, while progenitor cell derived hepatocyes appeared later in disease and their extent correlated with disease stage. Proliferation indices of all cell types correlated with disease activity. Progenitor cell derived hepatocytes accrue in chronic hepatitis, possibly related to native hepatocellular dysfunction. However, the fate of these hepatocytes is unclear.
AbstractList Progenitor cell activation with subsequent maturation to hepatocytes and cells of the biliary lineage has been demonstrated in a variety of chronic liver diseases but the kinetics and magnitude of the progenitor cell response has not been adequately studied in detail in chronic hepatitis. We undertook this study to evaluate factors responsible for the progenitor cell/ductular response and further dissect the role of disease grade and stage as determinants of hepatocellular differentiation of bipotential progenitor cells in chronic hepatitis.BACKGROUND/AIMSProgenitor cell activation with subsequent maturation to hepatocytes and cells of the biliary lineage has been demonstrated in a variety of chronic liver diseases but the kinetics and magnitude of the progenitor cell response has not been adequately studied in detail in chronic hepatitis. We undertook this study to evaluate factors responsible for the progenitor cell/ductular response and further dissect the role of disease grade and stage as determinants of hepatocellular differentiation of bipotential progenitor cells in chronic hepatitis.Cytokeratin 7 (and 19) stained biopsies from patients with chronic hepatitis C (n = 47), hepatitis B (n = 20), and autoimmune hepatitis (n = 20) were studied. Ploidy analysis and proliferation indices were evaluated in a subset of cases.METHODSCytokeratin 7 (and 19) stained biopsies from patients with chronic hepatitis C (n = 47), hepatitis B (n = 20), and autoimmune hepatitis (n = 20) were studied. Ploidy analysis and proliferation indices were evaluated in a subset of cases.Ductular reactions were present in the majority of cases (97%), appeared early in disease, and correlated with disease activity, while progenitor cell derived hepatocyes appeared later in disease and their extent correlated with disease stage. Proliferation indices of all cell types correlated with disease activity.RESULTSDuctular reactions were present in the majority of cases (97%), appeared early in disease, and correlated with disease activity, while progenitor cell derived hepatocyes appeared later in disease and their extent correlated with disease stage. Proliferation indices of all cell types correlated with disease activity.Progenitor cell derived hepatocytes accrue in chronic hepatitis, possibly related to native hepatocellular dysfunction. However, the fate of these hepatocytes is unclear.CONCLUSIONSProgenitor cell derived hepatocytes accrue in chronic hepatitis, possibly related to native hepatocellular dysfunction. However, the fate of these hepatocytes is unclear.
Progenitor cell activation with subsequent maturation to hepatocytes and cells of the biliary lineage has been demonstrated in a variety of chronic liver diseases but the kinetics and magnitude of the progenitor cell response has not been adequately studied in detail in chronic hepatitis. We undertook this study to evaluate factors responsible for the progenitor cell/ductular response and further dissect the role of disease grade and stage as determinants of hepatocellular differentiation of bipotential progenitor cells in chronic hepatitis. Cytokeratin 7 (and 19) stained biopsies from patients with chronic hepatitis C ( n=47), hepatitis B ( n=20), and autoimmune hepatitis ( n=20) were studied. Ploidy analysis and proliferation indices were evaluated in a subset of cases. Ductular reactions were present in the majority of cases (97%), appeared early in disease, and correlated with disease activity, while progenitor cell derived hepatocyes appeared later in disease and their extent correlated with disease stage. Proliferation indices of all cell types correlated with disease activity. Progenitor cell derived hepatocytes accrue in chronic hepatitis, possibly related to native hepatocellular dysfunction. However, the fate of these hepatocytes is unclear.
Progenitor cell activation with subsequent maturation to hepatocytes and cells of the biliary lineage has been demonstrated in a variety of chronic liver diseases but the kinetics and magnitude of the progenitor cell response has not been adequately studied in detail in chronic hepatitis. We undertook this study to evaluate factors responsible for the progenitor cell/ductular response and further dissect the role of disease grade and stage as determinants of hepatocellular differentiation of bipotential progenitor cells in chronic hepatitis. Cytokeratin 7 (and 19) stained biopsies from patients with chronic hepatitis C (n = 47), hepatitis B (n = 20), and autoimmune hepatitis (n = 20) were studied. Ploidy analysis and proliferation indices were evaluated in a subset of cases. Ductular reactions were present in the majority of cases (97%), appeared early in disease, and correlated with disease activity, while progenitor cell derived hepatocyes appeared later in disease and their extent correlated with disease stage. Proliferation indices of all cell types correlated with disease activity. Progenitor cell derived hepatocytes accrue in chronic hepatitis, possibly related to native hepatocellular dysfunction. However, the fate of these hepatocytes is unclear.
Author Park, Soo Mi
Eleazar, Jennifer A.
Chin, Steven
Memeo, Lorenzo
Lefkowitch, Jay H.
Mansukhani, Mahesh M.
Bhagat, Govind
Jhang, Jeffrey S.
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  givenname: Jeffrey S.
  surname: Jhang
  fullname: Jhang, Jeffrey S.
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  givenname: Mahesh M.
  surname: Mansukhani
  fullname: Mansukhani, Mahesh M.
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  givenname: Steven
  surname: Chin
  fullname: Chin, Steven
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  givenname: Soo Mi
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https://www.ncbi.nlm.nih.gov/pubmed/15582132$$D View this record in MEDLINE/PubMed
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Issue 6
Keywords Cytokeratin
Ploidy
Ductular reaction
Chronic hepatitis
Stage
Grade
Bipotential progenitors
Hepatic disease
Hepatitis
Regeneration
Chronic
Hepatocyte
Digestive diseases
Expansion
Progenitor cell
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Snippet Progenitor cell activation with subsequent maturation to hepatocytes and cells of the biliary lineage has been demonstrated in a variety of chronic liver...
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SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Bile Ducts - pathology
Biological and medical sciences
Bipotential progenitors
Cell Division
Child
Child, Preschool
Chronic hepatitis
Cytokeratin
DNA - metabolism
Ductular reaction
Female
Gastroenterology. Liver. Pancreas. Abdomen
Grade
Hepatitis B, Chronic - pathology
Hepatitis B, Chronic - physiopathology
Hepatitis C, Chronic - pathology
Hepatitis C, Chronic - physiopathology
Hepatitis, Autoimmune - pathology
Hepatitis, Autoimmune - physiopathology
Hepatocytes - pathology
Humans
Immunohistochemistry
Infant
Keratin-7
Keratins - metabolism
Liver - metabolism
Liver - pathology
Liver - physiopathology
Liver Regeneration
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Ploidy
S Phase
Stage
Stem Cells - pathology
Title Progenitor cell expansion: an important source of hepatocyte regeneration in chronic hepatitis
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0168827804003794
https://dx.doi.org/10.1016/j.jhep.2004.08.017
https://www.ncbi.nlm.nih.gov/pubmed/15582132
https://www.proquest.com/docview/67154780
Volume 41
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