At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 39; no. 2; pp. 61 - 71
• Main Authors: Shen, Han-Ming, Mizushima, Noboru
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2014
• Subjects: Animals; Arabidopsis - genetics; Arabidopsis - metabolism; autophagosome; autophagy; Autophagy - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; biogenesis; Extracellular Signal-Regulated MAP Kinases - genetics; Extracellular Signal-Regulated MAP Kinases - metabolism; Gene Expression Regulation; human health; Humans; lysosome; lysosomes; Lysosomes - metabolism; Lysosomes - pathology; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; neurodegenerative diseases; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Phagosomes - metabolism; Phagosomes - pathology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Signal Transduction; SNARE proteins; SNARE Proteins - genetics; SNARE Proteins - metabolism; soluble N-ethylmaleimide-sensitive factor attachment protein receptor; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; transcription factor EB; soluble N-ethylmaleimide-sensitive factor attachment protein receptor; neurodegenerative diseases; autophagy; mechanistic target of rapamycin complex 1; transcription factor EB; lysosome; autophagosome

•Lysosomes perform the key degradative function for all forms of autophagy.•TFEB-mediated lysosomal biogenesis occurs via suppression of MTORC1.•Lysosomes are consumed and reformed by autophagy.•Stx17 is a newly-discovered autophagosomal SNARE that mediates autophagosome–lysosome fusion.•Lysosomal f...