The Impacts of Antivirals on the Coronavirus Genome Structure and Subsequent Pathogenicity, Virus Fitness and Antiviral Design

• Published in: Biomedicines Vol. 8; no. 10; p. 376
• Main Authors: Lin, Ching-Hung, Yang, Cheng-Yao, Ou, Shan-Chia, Wang, Meilin, Lo, Chen-Yu, Tsai, Tsung-Lin, Wu, Hung-Yi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.09.2020; MDPI
• Subjects: Antiviral agents; antiviral drug; Coronaviridae; coronavirus; Coronaviruses; COVID-19; Disease control; genome structure; Genomes; Innate immunity; Medical importance; Medical treatment; Middle East respiratory syndrome; Mutation; Pathogenicity; remdesivir; Severe acute respiratory syndrome coronavirus 2; Spike protein; Vaccine development; Vaccines; Viruses; United States > US; pathogenicity; innate immunity; antiviral drug; spike protein; coronavirus; genome structure; remdesivir

With the global threat of SARS-CoV-2, much effort has been focused on treatment and disease control. However, how coronaviruses react to the treatments and whether the surviving viruses have altered their characteristics are also unanswered questions with medical importance. To this end, bovine coro...