The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells

• Published in: Cell Vol. 161; no. 6; pp. 1437 - 1452
• Main Authors: Guo, Fan, Yan, Liying, Guo, Hongshan, Li, Lin, Hu, Boqiang, Zhao, Yangyu, Yong, Jun, Hu, Yuqiong, Wang, Xiaoye, Wei, Yuan, Wang, Wei, Li, Rong, Yan, Jie, Zhi, Xu, Zhang, Yan, Jin, Hongyan, Zhang, Wenxin, Hou, Yu, Zhu, Ping, Li, Jingyun, Zhang, Ling, Liu, Sirui, Ren, Yixin, Zhu, Xiaohui, Wen, Lu, Gao, Yi Qin, Tang, Fuchou, Qiao, Jie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.06.2015
• Subjects: Cell Movement; Chromosomes, Human, X; Cluster Analysis; DNA; DNA Methylation; Embryo, Mammalian - metabolism; epigenetics; Female; females; genes; Germ Cells - metabolism; gonads; Histones - metabolism; Humans; landscapes; Male; males; oocytes; pregnancy; Principal Component Analysis; SOX Transcription Factors - metabolism; totipotency; Transcriptome

Germ cells are vital for transmitting genetic information from one generation to the next and for maintaining the continuation of species. Here, we analyze the transcriptome of human primordial germ cells (PGCs) from the migrating stage to the gonadal stage at single-cell and single-base resolutions...