Tyrosine Is a Booster of Leucine-Induced Muscle Anabolic Response

• Published in: Nutrients Vol. 16; no. 1; p. 84
• Main Authors: Tamura, Kotaro, Kitazawa, Hidefumi, Sugita, Satoshi, Hashizume, Kohjiro, Iwashita, Masazumi, Ishigami, Takaaki, Minegishi, Yoshihiko, Shimotoyodome, Akira, Ota, Noriyasu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.12.2023; MDPI
• Subjects: Amino acids; Antibodies; Experiments; Kinases; mTOR complex 1; muscle cells; Muscles; Musculoskeletal system; Phenols; Phosphorylation; Protein biosynthesis; Protein synthesis; Proteins; Sestrin1/2; Soap and cleaning agents industry; Tyrosine; Massachusetts; Japan; St Louis Missouri; United States > US; mTOR complex 1; Sestrin1/2; muscle cells; amino acids

Leucine (Leu), an essential amino acid, is known to stimulate protein synthesis in the skeletal muscle via mTOR complex 1 (mTORC1) activation. However, the intrinsic contribution of other amino acids to Leu-mediated activation of mTORC1 signaling remains unexplored. This study aimed to identify amin...