A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases

• Published in: Viruses Vol. 17; no. 4; p. 562
• Main Authors: Hage, Adam, Janes, Mikhaila, Best, Sonja M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.04.2025; MDPI
• Subjects: Animals; Apoptosis; Autophagy; Care and treatment; Central nervous system; Central nervous system diseases; Central Nervous System Diseases - drug therapy; Central Nervous System Diseases - therapy; CNS diseases; CRISPR; Disease; Drug development; E3 ubiquitin ligase; Enzymes; Genomes; Health aspects; Humans; Immunity (Disease); Immunity, Innate; Innate immunity; Ligases; Medical research; Medicine, Experimental; Nervous system; Neurodegenerative diseases; Neurosciences; Pathogens; Physiological aspects; PROTAC; protein degradation; Proteins; Review; Signal Transduction; tripartite motif (TRIM); Tripartite Motif Proteins - genetics; Tripartite Motif Proteins - metabolism; Tripartite Motif Proteins - therapeutic use; Ubiquitin; Ubiquitin-Protein Ligases - metabolism; Viral infections; Virus diseases; Virus Diseases - drug therapy; Viruses; West Nile virus; United States; disease therapeutic; innate immunity; PROTAC; CNS diseases; trim-away; tripartite motif (TRIM); E3 ubiquitin ligase; protein degradation; ubiquitin; virus infection

Tripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity. This ubiquitous participation in fundamental aspects of biology has made TRIM proteins a fo...